Ksenalten

Description overdue on 09/25/2014

• Latin name: Xenalten
• ATC code: A08AB01
• Active substance: Orlistat (Orlistatum)
• Manufacturer: AF Obolensky, JSC (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Ksenaltena (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The main ingredient of the drug - ABOUT rlistat . Optional components include: MCC . sodium lauryl .   talc . povidone . krahamala sodium glycolate .

Hard gelatin capsules also contain Titanium dioxide . patented blue dye .   gelatin .

Product form

Available in capsule form, blue or white. The capsules containing the pellets.

Pharmacological action

Ksenalten is a special gastrointestinal lipase inhibitor .

Pharmacodynamics and pharmacokinetics

This drug binds to the lumen of the stomach and small bowel with active serine site stomach   and pancreatic lipase . Difficult lipolysis, coming from the food in the form of TG . They are not absorbed Accordingly, the body gets fewer calories because of what he has to spend the available stocks. This allows you to reduce weight. The content of fat in the stool increased after 1-2 days.

Fats from food, inhibited   active ingredient in about 30%.

The extent of absorption of the drug - low. It is not determined in plasma by 8 hours after ingestion.

Systemic exposure   minimal. After oral administration, the degree of connection with plasma proteins - 99%. Preferably cleaved in the gastrointestinal tract to form inactive metabolites . The half-life - about 1-2 hours. It is shown mainly through the intestine and bile.

Indications

The main purpose of Ksenaltena - obesity . It can be used in combination with hypocaloric   dietetic food. In addition, a drug often used to reduce the probability of weight regain after a successful decrease in body weight. It can be used for such risk factors as diabetes .   dyslipidemia . arterial hypertension .

Contraindications

The drug does not apply to:

• hypersensitivity to its components;
• cholestasis ;
• pregnancy ;
• Lactation ;
• malabsorption syndrome ;
• childhood.

With care it is prescribed for giperoksalaturii   at history   and nephrolithiasis .

Side effects

Adverse effects associated with the use Ksenaltena may be as follows:

• gastrointestinal tract: loose stools, oily discharge from the rectum, pain or abdominal discomfort, urgency to defecate, increased frequency of defecation, flatulence, steatorrhea, soft stools, fecal incontinence, pain in the rectum, loss of teeth and gums, bloating.

These reactions occur primarily at the beginning of the course and weakly expressed, but their frequency can be improved by increasing the content of fat in the daily menu. Skilled is important to pre-notify the patient and recommend an appropriate diet to avoid undesirable effects;

• respiratory system:   infection of the upper and lower respiratory tract;
• nervous system: headache ;
• kidney and urinary tract: urinary tract infection;
• Other: flu . dysmenorrhea , Weakness, anxiety.

In rare cases may also occur itch . rash . bronchospasm . hepatitis . hives . angioedema . anaphylaxis Increase in activity transaminases   and alkaline phosphatase .

If worsening of any side effects, seek medical advice.

Instructions for use Ksenaltena (method and dosage)

Instructions for use Ksenaltena reported that the drug is used orally one capsule three times a day with meals or an hour after her . If the menu was lean, the reception can be skipped.

Overdose

Cases of overdose have not been studied. If the dosage is much higher than the norm, it is necessary to observe the patient's condition during the day.

Cooperation

Contraindicated combination with Cyclosporine As the content of the latter in the blood plasma is markedly reduced.

In addition, interaction with Ksenaltena indirect anticoagulants   may reduce the level of prothrombin   and changes in indicators INR So the reception of these funds should be carefully monitored.

The drug reduces the extent of absorption betakarotena That is, certain food additives, at 30% and about 60% inhibits   absorption tocopherol acetate   and increases hypolipidemic   effect bioavailability of pravastatin , Wherein the plasma concentration of the latter is increased by 30%.

The combination of vitamins A, E, D and K with the active substance Ksenaltena reduces their absorption. Thus, before multivitamins should pass a minimum of 2 hours.

Oral Dosage gipoglekimicheskih   drugs in combination with Ksenaltenom should be well adjusted.

Joint reception Amiodarone   It is possible only if the prescribing physician.

It should also be borne in mind that at the use of orlistat bioavailability of oral contraceptives may be reduced That increases the chance of pregnancy. So while taking Ksenaltena recommended to use additional means of protection.

Terms of sale

Sold by prescription only.

Storage conditions

Keep the medication you need in a dry place out of reach of young children and well-protected from the light. The temperature should be no higher than 25 ° C.

Shelf life

2 years from the date of issue.

Analogs

Match code ATC 4th level:

• Orlistat
• Orsoten
• Xenical

The medicine has the following analogues:

• Ally ;
• Orlimaks ;
• Xenical ;
• Orsoten ;
• Orsoten slim .

Ksenalten or Xenical - Which is Better?

The main analogue Ksenaltena many call Xenical . In fact, they are one and the same remedy. Except that Xenical   It has a long half-life. So the answer to the question: "Ksenalten or Xenical   - what's better? " - does not exist. Many, however, preferred first agent because it has a lower cost.

Reviews Ksenaltene

Reviews Ksenaltene for weight loss, usually positive. Those who have already dropped excess weight   with it, they argue that it is literally a miracle remedy. Many believe that it is much more effective than other advertised pills, and can get rid of fat in the shortest possible time. Reviews of slimming Ksenaltene also give evidence of the fact that adverse reactions when used are rare and very small.

Price Ksenaltena where to buy

Price Ksenaltena, pack 21 capsule which is about 750 rubles. Some patients, however, prefer to buy the drug directly into the bulk. Price Ksenaltena in a package of 42 pieces - about 1,000 rubles, and in a package of 84 pieces - 1700 rubles.

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