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The preparation sibutramine effectively inhibits the reuptake neurotransmitters from the synaptic cleft, thereby significantly reducing levels of appetite and, consequently, the number of daily meals. The drug increases thermogenesis and affects the brown adipose tissue. Due to its effects in humans occurs the formation of active metabolites Which more effectively inhibit the reuptake Serotonin and noradrenaline . During active weight reduction in serum concentration increases HDL level decreases triglycerides . cholesterol . Uric acid . During treatment with this agent may rise slightly blood pressure at rest and pulse. After his admission absorption from the gastrointestinal tract occurs at 77%. If the drug is used in the process of eating, metabolites decrease Cmax by 30%, while three hours increases the time to achieve. Due to a series of reactions are formed inactive metabolites that are mostly excreted through the kidneys.
Indications and methods of use of the drug:
For a comprehensive maintenance therapy drug is prescribed in patients with nutritional obesity Whose body mass index greater than 30 kg / m2. It is used in alimentary obesity with a BMI of 27 kg / m2 or more, which combines non-insulin diabetes or dyslipoproteinaemia .
The drug sibutramine should be consumed once a day, in the morning, with plenty of drinking water and without chewing. The initial dose should be 10 mg, but if the drug is poorly perceived, the dose can be reduced by half. If the desired effect is not observed, the dose if tolerated agent can be increased to 15 mg per day to four weeks later. Treatment with this drug can last for one year.
Contraindications and possible side effects:
The drug sibutramine should not be used under the following conditions: high sensitivity, organic background to obesity, severe eating disorders ( bulimia or anorexia ), Mental illness, de la Tourette syndrome . You can not use in patients with concurrent MAO inhibitor therapy or in their application for two weeks before you start taking this drug, taking serotonin reuptake inhibitors, taking any medications that affect the central nervous system, hypnotics, drugs that contain tryptophan And other drugs for weight reduction of the central action. This drug is also contraindicated in diseases of the cardiovascular system, hypertension (if there is more than blood pressure 145/90 mm Hg. st), thyrotoxicosis , Cerebrovascular disease, severe violations of the liver, kidneys, pheochromocytoma , Benign prostatic hyperplasia, closure glaucoma . pregnancy and breastfeeding .
The drug is limited to the use of children and adolescents who are under 18 years old and people over 65, as well as epilepsy and motor and verbal tick .
As a side effect during studies most often had headaches, dry mouth, insomnia . anorexia . constipation .
Rarely can manifest flu-like symptoms , Back pain, chest, neck, allergic reactions .
Caution when administered sibutramine Arrhythmias a history cholelithiasis , Chronic circulatory failure, coronary artery disease, hypertension, neurological disorders, disturbances in the functioning of liver, kidney, mild to moderate, with a history of motor and verbal tics. Women who are in childbearing age should be sure to use the funds for protection from conception during treatment with this drug.
Adverse effects during the treatment may occur in the first four weeks of use of the drug. They are generally not severe. Over time, they become less pronounced.
In work CNS may insomnia, insomnia, dry mouth, dizziness, nervousness, paresthesia , Anxiety, change in taste, alarm , earache. In work Cardiovascular manifested tachycardia, increased blood pressure, vasodilatation. In work GI may anorexia, gastritis, dyspepsia , Constipation, as can sometimes occur nausea, exacerbation of hemorrhoids. In work Respiratory system may rhinitis, sinusitis, pharyngitis , Cough, laryngitis . Also, as the side effects may occur skin rash, sweating, acne . dysmenorrhea , Urinary tract infection, vaginal candidiasis .
Specific recommendations:
During the treatment you need to keep under control the blood pressure and heart rate. Be particularly careful to monitor the state should be taken in patients with hypertension. If you double-control when measuring blood pressure exceeds 145/90 mmHg, the Message reception is suspended.
The drug can affect the ability to work with dangerous machinery and driving vehicles. Women of childbearing age who are in the process of the drug sibutramine should be required to wear protective contraceptives. During treatment is not recommended to drink alcohol.
According to the drug treatment is recommended when all other measures taken to reduce weight, were ineffective. Therapy should take place under the close supervision of a specialist.
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