Description overdue on 11/11/2014
- Latin name: Depo-Medrol
- ATC code: H02AB04
- Active substance: Methylprednisolone (Methylprednisolone)
- Manufacturer: Pfizer Menyufekchuring Belgium, Belgium / USA
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Depo-Medrol, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In 1 ml slurry Depo-Medrol be contained 40 mg methylprednisolone .
Excipients: sodium chloride, macrogol 3350 chloride, myristyl-γ-picoline, sodium hydroxide, hydrochloric acid Water.
Product form
Depo-Medrol is a white suspension.
1 or 2 ml of the suspension in the vial; one bottle in the package.
Pharmacological action
Glucocorticoid.
Pharmacodynamics and pharmacokinetics
Prednisolone slows the release of IL first and second type, Gamma-interferon from macrophages and lymphocytes. Renders anti-allergic, anti-inflammatory, desensitizing, antishock, immunosuppressive and antitoxic action. Delay release adrenocorticotropic hormone and beta lipotropina Without lowers beta-endorphin . It inhibits secretion follicle stimulating hormone and thyroid stimulating hormone . Increases the excitability of the nervous system and red blood cell count, reduces the number of eosinophils and lymphocytes. It interacts with cytoplasmic receptor into the nucleus to induce protein synthesis.
Following intramuscular administration of the maximum serum concentration occurs within 7, 5 hours. Following intra-articular injection of 40 mg both knee joint maximum serum concentration is achieved in 5-8 hours. Release of the drug into the bloodstream from the joint continues for weeks.
Metabolism occurs in the liver. Excreted in the urine in the form sulfates, glucuronides and unconjugated compounds .
Indications
- Insufficiency of adrenal glands, adrenal hyperplasia (congenital) thyroiditis . hypercalcemia etiology of cancer.
- Rheumatic diseases . pemphigus, exfoliative dermatitis, collagen, bullous dermatitis herpetiformis, severe multiforme erythema , Severe psoriasis .
- Allergic diseases . berylliosis . sarcoidosis . Loffler's syndrome . tuberculosis (in combination therapy).
- Thrombocytopenic purpura, acute leukemia, hemolytic anemia, erythroblastopenia, aplastic anemia, secondary thrombocytopenia .
- Nephrotic syndrome.
- Ulcerative colitis.
- Multiple sclerosis . trichinosis , Brain edema, tuberculous meningitis .
- Organ transplant.
- Diseases of the musculoskeletal system of different genesis.
Contraindications
- Intravenous administration.
- System mikoinfektsii .
- Hypersensitivity to the drug.
- For intra-articular injection, and injection into the lesion: abnormal bleeding, arthroplasty , Intraarticular fracture, an infectious process in a joint, systemic infectious disease, the absence of inflammation in the joint, aseptic necrosis bones.
Side effects
- From the hormonal sphere: changes in glucose tolerance, diabetes . syndrome Itsenko-Cushing's, hypofunction of of the adrenal glands , Developmental delay in children.
- From the digestive system: nausea, vomiting, pancreatitis , Bleeding or perforation of the bowel, ulcer 12 duodenal ulcer or stomach , Change in appetite.
- From the circulatory system: Arrhythmia . bradycardia , ECG changes, increased pressure hypercoagulation, thrombosis .
- From the senses: vision loss, exophthalmos, posterior subcapsular cataracts , Increased intraocular pressure, the occurrence of secondary infections of the eyes.
- From the nervous system: disorientation, delirium, hallucinations, bipolar disorder, paranoia, depression , Nervousness, headache, insomnia, seizures .
- On the part of metabolism: hypocalcemia , Weight gain, increased sweating, hypernatremia
- From the musculoskeletal system: osteoporosis , Slowing of growth in children, muscle tendon rupture, atrophy .
- Skin: slow healing of wounds, ecchymosis, petechiae , Discoloration, acne .
- Allergic reactions: pruritus, rash, anaphylactic shock .
- Other: leukocyturia , Exacerbation of infection, a syndrome of "cancellation", burning, pain, scarring, infection at the injection site.
- When intra-articular injection - increased pain in the joint.
Depo-Medrol, instructions for use (method and dosage)
According to the instructions Depo-Medrol is administered periarticular, intra-articularly, in the pathological hotbed of, intrabursalno; instillation into the rectum.
Children under 18 years: the adrenal insufficiency - 0.14 mg per kg or 4 mg per square meter of body surface per day, 2 days; for other indications - 0.14-0.836 mg per kg or 4.15-25 mg per square meter of body surface after 12-24 hours.
Adults - IM 40-120 mg per day, duration of treatment - up to a month.
With shock and transplant rejection : 5-20 mg / kg every 0.5-24 hours.
Intraarticular - 6-80 mg: large joints - 41-80 mg, the average - 11-40 mg, small - 6-10 mg.
When administered into the pleural or peritoneal cavity - to 100 mg when administered epidurally - up to 80 mg, in a zone of skin lesions - 30-60 mg; enema - 50-120 mg. Abolition of the drug Depo-Medrol should be performed gradually.
Overdose
Such cases are not described.
Cooperation
The drug Depo-Medrol should not be mixed with other solutions.
Joint use methylprednisolone and cyclosporine may cause mutual inhibition of metabolism.
Phenobarbital, rifampicin, Fenitoi n increase clearance methylprednisolone , Which requires an increase in the dose.
Oleandomitsina and K etokonazol inhibit metabolism methylprednisolone .
Methylprednisolone increases clearance A Spirin .
Terms of sale
Prescription.
Storage conditions
Keep away from children. Store at a temperature of 20-25 degrees. It is forbidden to store upside down, and the storage of opened vials of the drug.
Shelf life
Five years.
Cautions
This does not affect the reaction and ability to drive.
Analogs
Flosteron
Medrol
Solu-Medrol
Diprospan
Kenalog
Analogues of drugs are Urbazon and Metipred .
Babies
Use with caution.
During pregnancy (and lactation)
The drug is contraindicated in these patients.
Reviews
Reviews of drug evidence of its effectiveness. Reported side effects are not common.
Depo-Medrol price, where to buy
Price of the drug Depo-Medrol 40 mg in Russia amounts to 71-81 ruble, in the Ukraine fluctuates in the district 65-75 hryvnia.
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