Riabal

Description overdue on 08/18/2014

• Latin name: Riabal
• ATC code: A03AB18
• Active substance: Prifiniya bromide (Prifinium bromide)
• Manufacturer: Al-Hikma Pharmaceuticals (Jordan)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Side effects
• Instructions on Riabal (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Riabal children
• Newborns
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Because the drug release in the form of an injectable solution, a syrup for oral administration, tablets and its chemical composition will depend, primarily, on some form of release of the drug.

The composition of 1 ml. syrup Riabal includes 5 mg. prifiniya bromine . In a round tablet, sugar-coated pink contained 30 mg. similar activity of the active compound, and 1 ml. solution for injection - 7, 5 mg.

In addition, in the tablet form of the drug such ancillary components are present as: salt of carmellose sodium, povidone, starch, talc, magnesium stearate, carnauba wax, silicon dioxide , and   sucrose, and titanium dioxide .

Product form

Riabal syrup packaged in bottles, the nominal volume of 50-60 ml., Placed in a cardboard box and is provided with a pipette (volume at 0, 4 ml) for ease of use.

Tablets (30 mg.) Coated with specialized membrane envelope is packaged in blisters, usually 20 pcs. in each, and then packed in a cardboard box (1 blister).

Solution for intravenous injection is produced in ampoules nominal volume of 2 ml. each, then placed in a cardboard box (6 vials).

Pharmacological action

Such active as the active compound prifiniya bromide acts on peripheral m-cholinergic receptors , Blocked and thereby inhibits gastric acid secretion. Riabal has pronounced antispasmodic And furthermore,   antiemetic effects .

Pharmacodynamics and pharmacokinetics

Since the drug, which is included in the drug treated in accordance with the scientific classification for M-holinoblokatoram, assistants include it in the group quaternary ammonium compounds . Thanks to its distinctive properties Riabal has a strong influence on M-cholinergic receptors , Which are differently located in the body, for example, they can be found in tissues of the stomach, intestinal tract , and   genito-urinary and biliary tract.

Riabal influences M-cholinergic receptors That as a result lose sensitivity to acetylcholine (a neurotransmitter That transmits neuromuscular impulses and plays a leading role in parasympathetic nervous system the human body). As a result of such exposure the drug prevents the formation of cramps in the esophagus, uterus, biliary ducts As well as   ureters .

Riabal weakens peristalsis And lowers the tone smooth muscles of the digestive tract It reduces activity pancreatic secretion   and production of pepsin and HSI . In addition, the drug increases   motor activity of the digestive tract ( corrective effects ) And also promotes emptying stomach.

Active drug compound contained in the composition of the preparation, has no toxic effects   on the human body, because it does not penetrate through natural blood-brain barrier . Because of this, Riabal can be used in the treatment of newborn babies, as well as in long-term therapeutic treatment without fear of damaging effects for circulatory system, liver , and kidney .

When receiving Riabal into the active substance is absorbed slowly enough stomach . The maximum concentration prifiniya bromide   (Cmax-7-15 ng / ml.) After oral administration of the drug reaches its maximum after 2 hours. Most Riabal output from the body urine .

Indications

The drug suppresses pain syndrome Caused by spasms , In diseases such as:

• chronic gastritis;
• enterocolitis ;
• acute gastritis ;
• dyskinesia ;
• calculous cholecystitis ;
• gastric and duodenal ulcers;
• bowel disease , eg, ileus   or flatulence ;
• urolithiasis disease ;
• cystitis ;
• Pancreatic inflammation ;
• bloating and colic in newborns;
• algomenorrhea .

This drug is used in the preparations of the test digestive tract And before   X-ray examination   and after radiation therapy . Everything else, Riabal include a comprehensive program of therapeutic treatment of such organic diseases digestive tract as gastroenteritis, hypertension, hyperthermia.

Side effects

It is extremely rare in the use of the drug can occur adverse effects such as:

• allergic reaction;
• dry mouth;
• weakness;
• hives;
• headache ;
• increase   Intraocular , and Blood Pressure ;
• constipation ;
• angioedema ;
• drowsiness ;
• nausea ;
• redness and itching of the skin .

Instructions on Riabal (method and dosage)

In accordance with instructions for use Syrup Riabal   used in the treatment of children under the age of 6 years. The dosage and schedule of reception syrup depends on the child's age, his health, and the nature and type of disease.

The recommended daily dose Riabal for infants and children under the age of 3 months is 6 mg., From 3 to 6 months - 6-12 mg., By six months and a year - 12 mg., From one year and up to 6 ti years - 30-60 mg. Typically, the drug is taken 3 times a day for two weeks.

Tablets Riabal   indicated for children aged 6 years of age at a dose of 60-90 mg. per day, for adults - 90-180 mg. It is also to take two weeks or three times a day. The initial single dose of the drug solution   intravenous and intramuscular administration   1-2 ml., it can be increased to a maximum of 30 mg.

On average, per day should be administered intravenously to a patient no more than 45 mg. active active compound. It should be noted that when using Riabal Injectable   solution was added slowly (about one minute). Failure to comply with the rules indicated above while taking the drug, patients may skyrocket arterial pressure , Leading to a state of shock.

Often, to enhance the effect of the drug is mixed with Riabal 0 9% sodium sodium chloride (NaCl) .

Overdose

Overdose of the use of this drug compound may occur in case of exceeding the recommended average daily dose of 10 times. If overdose manifest symptoms such as: weakness, tachycardia, dizziness, hypotension and hallucinations.

To eliminate the negative effects of an overdose Riabal held ventilation , and gastric lavage . If necessary, patients prescribed Laxatives . Neostigmine, and Physostigmine .

Cooperation

To avoid the risk potentiation   and the occurrence of severe side effects of the drug should not be used in conjunction with narcotic analgesics, antihistamines , and antipsihotropnymi and antiparkinsonian drugs antidepressants and M-anticholinergic drugs .

Terms of sale

Prescription.

Storage conditions

Riabal stored at a temperature of 25 ° C 15 out of the reach of children.

Shelf life

3 years.

Cautions

Special care should be used drug in the treatment of patients with diseases respiratory, cardiovascular and digestive system At   reflux esophagitis and hyperthyroidism, liver disease, myasthenia gravis, preeclampsia, cerebral palsy and Down's syndrome, because side effects may occur Riabal example tachycardia, atrial fibrillation, heart failure, hemorrhage, hypertension, stenosis, coronary artery disease, fever, esophageal achalasia   and others.

Analogs Riabal

Among the main structural analogues Riabal are the following similar chemical composition and the effects of medicinal products:

• Bebinos;
• Bromocriptine;
• Ganaton;
• Bimaral;
• Gaviscon;
• Digestal;
• Halidorum;
• Domperidone;
• Gastenorm forte;
• Itomed;
• Karbopekt;
• Gestid;
• Markalakt;
• Disflatil;
• Mezim forte;
• Iberogast;
• Metov;
• Yogulakt;
• Milk of-magnesia;
• Maalox;
• Motonium;
• Metamol;
• No-spa forte;
• Metoclopramide;
• Panzinorm forte;
• Motilak;
• Penzital;
• Pancreatin;
• Rennie;
• Perinorm;
• Simikol;
• Sab Simplex;
• Spazmonet;
• Smecta;
• Festal;
• Trimedat;
• Holenzim;
• Hilak forte;
• Tseolat;
• Hofitol;
• Yunienzim;
• Espumizan.

Synonyms

No-spasm

Riabal children

Subject to the dosage of the drug is absolutely safe for the child's body. However, with care physicians should approach the use of the drug in the treatment of children with the disease respiratory, Down's syndrome , and   Cerebral Palsy .

Riabal for newborns

For newborns syrup Riabal safe subject to the recommended dose and schedule of administration of the drug.

During pregnancy (and lactation)

If there are no contraindications to take medicine during pregnancy   and Lactation is not prohibited.

Reviews Riabale

The bulk of these people positively expressed about the effectiveness of this drug. Riabal really fast to cope with the pain caused by spasms.

It is worth emphasizing that as medicine for newborn Riabale mixed reviews about. Some parents as a negative factor noted instantaneous occurrence of side effects in the form   rash, pruritus , and allergic reactions .

Price Riabal where to buy

Price Riabal vary depending on the region and release form of the drug.

Since the drug is not prescribed by law has passed re-registration procedure is currently not possible to buy syrup Riabal in Moscow, as well as throughout Russia in a simple pharmacy or through the Internet.

Syrup for infants Riabal (60 mg vial. With a pipette) can be purchased in Kiev, Kharkov, Dnepropetrovsk, Donetsk and other large Ukrainian cities at an average price of 40-50 USD.

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