Description overdue on 02/12/2014
- Latin name: Klacid
- ATC code: J01FA09
- Active substance: Clarithromycin (Clarithromycin)
- Manufacturer: Abbott S.p.A. (Italy)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use klatsid (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- With alcohol
- Klatsid children
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Antibiotic Klatsid contains the active ingredient clarithromycin As well as additional components: sodium calcium alginate, sodium alginate, lactose, dibasic anhydrous citric acid, stearic acid, povidone COA, magnesium stearate.
Product form
Klatsid 500 mg and 250 mg is made in the form of tablets, which are coated yellow. Tablets are oval in shape, the section indicated the presence of two layers: a yellow film and whitish core. The blister pack made of foil, can hold 7, 10 or 14 tablets, in a box made of cardboard packed 1, 2 or 3 of the blister.
Pharmacological action
Active ingredient clarithromycin included in the group of macrolides, semisynthetic antibiotics . Antibacterial produces the effect by inhibiting bacterial protein synthesis. Consistency tablet is such that the active ingredient is released gradually in the course of passage of the drug on the gastrointestinal tract. Clarithromycin active against the isolated and the standard bacterial cultures. Awesome effect observed in the application for the treatment of Legionnaires' disease, mycoplasma pneumonia etiology. Gram-negative bacteria do not show sensitivity to clarithromycin .
The active substance is active as an antibacterial agent against group A streptococci . pneumococcus , Golden aureus , Microbial pathogens, Haemophilus influenzae . Listeriosis . gonorrhea . pneumonia . pnevmohlamidoza . mischief . Chlamydia . faces , Sporotrichosis.
Those pathogens that are not sensitive to Oxacillin and Methicillin Also resistant to the influence clarithromycin .
Also noted a positive effect clarithromycin against the following microorganisms (efficacy and safety have not been confirmed in clinical trials): zelenyaschy streptococcus, peptokokki, streptococcus group B, C, F, G; pathogens Pasteurellosis birds pertussis , Human poisoning, Acne , Borrellioza, Syphilis , Enterocolitis.
During metabolism clarithromycin the body releases the active 14-hydroxyclarithromycin exhibiting microbial activity. Metabolism occurs in the human liver. If the person taking the drug regularly, there is a growing activity of its influence.
Pharmacokinetics and pharmacodynamics
Substance clarithromycin Associated with the blood well. The largest concentration of the drug is determined for 6 hours. The higher the dose the patient received, the longer the period of time it is removed from the body. Number metabolite (hydroxyclarithromycin 14) is not increased in parallel with the increase in dose of clarithromycin. The more is adopted klatsid dose, the smaller 14-hydroxyclarithromycin formed in the body.
Excreted drug eliminated via the kidneys and intestines (respectively 40% and 30% of the dose). Following oral administration of clarithromycin and its metabolite distributed in the tissues and body fluids, tissues, typically contained twice the drug as compared to serum.
No dosage adjustment is required funds liver disease. In diseases of the kidneys during excretion clarithromycin the body increases. Also, during the elimination of the drug is increased in the elderly.
Indications
Use of the drug Klatsid shown in the following diseases and conditions:
- infectious diseases of the respiratory tract, the lower divisions ( pneumonia . bronchitis and etc.);
- infectious diseases of the respiratory tract, the upper sections (with sore throat . sinusitis . pharyngitis and etc.);
- infections of the soft tissues of the skin ( folliculitis . mug and etc.);
- mycobacterial infections, which provoked Mycobacterium intracellulare and Mycobacterium avium;
- infection provoked by Mycobacterium fortuitum, Mycobacterium chelonae, Mycobacterium kansasii.
It is also practiced by the reception means to prevent infection provoked complex Mycobacterium avium (MAC). Appointed to reduce the frequency of symptoms of duodenal ulcer recurrence.
Contraindications
Do not take an antibiotic in the following cases:
- at high sensitivity organism to the means macrolide;
- at porphyria ;
- during pregnancy and breast-feeding ;
- children under 3 years of age.
Carefully agent indicated for disorders of the kidneys and liver.
You can not at the same time taking clarithromycin and these drugs: Terfenadine . C izaprid . D igidroergotamin . Pimozide . E rgotamin . A stemizol .
Side effects
If you enter Klatsid in / or performed oral agents may be a manifestation of a number of side effects. If you experience such effects after the in / or administration of oral tablets it is necessary to notify the specialist. The following manifestations:
- CNS : Change in taste, g olovnye pain .
- Digestive System : nausea , stomach ache, diarrhea . vomiting . dyspepsia .
- Local reactions when administered to a solution of : Inflammation at the injection site, phlebitis Pain during palpation.
- Laboratory findings : Increase in liver enzymes.
In addition to these side effects are possible side effects that occur less frequently:
- candidiasis oral cavity;
- thrombocytopenia . leukopenia ;
- anaphylactic reactions ;
- hypoglycemia ;
- mental disorders, insomnia ;
- dizziness . convulsions ;
- myalgia ;
- reversible hearing loss;
- Ventricular tachycardia ;
- stomatitis , Acute pancreatitis . glossitis ;
- abnormal liver function;
- hives . rash ;
- increased content of creatinine in the blood.
Instructions for use klatsid (method and dosage)
Instructions for use klatsid for children and adults includes receiving means inside, regardless of the meal.
Adult patients shows receiving 250 mg of clarithromycin twice a day. If untreated severe disease, mycobacterial infections, the dosage can be increased to 500 mg twice a day. In most cases, the treatment lasts from 5 to 14 days.
If the treatment is given suspension Klatsid , Instructions for use must be strictly observed. The suspension is indicated for the treatment of children, it can be taken without regard to food intake, can be taken with milk. To prepare to use the suspension to the vial should be gradually add water to the mark, and then shake. In 5 ml of a suspension of 60 ml containing 125 mg of clarithromycin; 5 ml of suspension 100 ml contains 250 mg of clarithromycin. Keep the slurry can be two weeks at room temperature.
Before giving the antibiotic Klatsid children must be thoroughly shaken suspension. The daily dosage recommended for children 7.5 mg calculated for 1 kg body weight twice a day. Maximum tolerated dose - 500 mg twice daily. Therapy may continue for 5 to 10 days.
Overdose
When very high doses of the drug for patients may experience the manifestation of signs of dysfunction of the digestive system. It is important to as quickly as possible to remove the remnants of the drug from the gastrointestinal tract, followed by symptomatic treatment.
Cooperation
It is strictly not allowed joint application clarithromycin and preparations Astemizole . Pimozide . Terfenadine . Cisapride Since in this case likely to develop serious side effects. In particular, it may be a manifestation of cardiac arrhythmias, including ventricular fibrillation, ventricular tachycardia.
With simultaneous use of clarithromycin and Ergotamine or Dihydroergotamine probably acute poisoning means a group of ergotamine. In particular, it can manifest limb ischemia, vascular spasm, and others. It is not allowed concomitant use of clarithromycin and ergot alkaloids.
Inducers of CYP3A induce the metabolism of clarithromycin. As a consequence, the concentration decreases clarithromycin and its efficiency. If simultaneously applied clarithromycin and R ifabutin , The plasma concentration increases Rifabutin and decreases the concentration of clarithromycin.
Preparations Nevirapine . Efavirenz . Rifabutin . Rifapentine Clarithromycin can accelerate metabolism, thereby reducing its concentration in plasma and increasing the concentration of its metabolite - 14-OH clarithromycin. As a result, therapeutic efficacy may be reduced.
Reduced concentration clarithromycin celebrated at a joint reception with his etravirine .
It is necessary to adjust the dose of medications at a joint reception and clarithromycin ritonavir .
In simultaneous treatment klatsid and oral hypoglycemic drugs or insulin may manifestation of severe hypoglycemia. It should constantly monitor the level of glucose.
At the same time taking the antibiotic Quinidine . Dizopiramid possible ventricular tachycardia.
Precautions must be taken clarithromycin those who receive drug - substrates isoenzyme CYP3A, and in combination with statins.
Concomitant treatment with clarithromycin and Simvastatin .
It is important to monitor the patient in the treatment of joint AT arfarinom clarithromycin, and because of the likelihood of bleeding.
In a joint reception and clarithromycin tadalafil . sildenafil . Vardenafil there is a need to reduce the dosage of the latter drugs.
Simultaneous treatment with antibiotics or theophylline and carbamazepine leads to increased concentrations of the drug in the bloodstream.
When using clarithromycin and triazolam likely effect on the central nervous system, as a consequence, develop drowsiness and confusion.
You can not at the same time taking clarithromycin and colchicine people who have violated the liver or kidneys.
In simultaneous treatment with clarithromycin and D igoksinom effects of the latter increases. Continuous monitoring of digoxin levels in blood serum.
There bidirectional effects of drugs while taking clarithromycin and atazanavir And clarithromycin and itraconazole, clarithromycin and saquinavir .
In treating both antibiotic and Amlodipine . Verapamil . diltiazem It increases the likelihood of hypotension.
Terms of sale
Pharmacies selling antibiotic prescription.
Storage conditions
It is necessary to protect the antibiotic from children, it should be kept at a temperature no higher than 30 ° C.
Shelf life
Shelf-life of the antibiotic - 3 years.
Cautions
People with liver disease may experience changes in serum enzyme indicators, from which tablets have to appoint cautiously.
Carefully appointed people simultaneously receiving other drugs that are metabolized by the liver.
For prolonged antibiotic treatment, the formation of colonies with more insensitive for fungi and bacteria.
In chronic liver disease should regularly monitor the blood serum enzymes.
Might appear pseudomembranous colitis with antibiotic treatment. It is also possible to change the normal intestinal microflora.
Precautions should be prescribed the drug to people, severe heart failure, bradycardia, hypomagnesemia. It is necessary to constantly monitor the ECG, determining an increase of the interval QT.
Perhaps greater symptom myasthenia people who take clarithromycin.
The powder for suspension Klatsid contains sucrose, it should be noted that people suffering diabetes .
In the treatment of clarithromycin should be carefully manage the transport and perform actions that require high concentration of attention.
Synonyms
Clarithromycin
Analogs klatsid
Klatsid CP
Rulid
Klabaks
Fromilid
Azitroks
Hemomitsin
Vilprafen
Rovamycinum
Roxithromycin
Clarithromycin
Azithromycin
Midecamycin
Sumamed
Analogs klatsid - means, which are in the same group and have similar klatsid active substance. This Medication Klatsid CP . Klabaks . Klareksid . Binoklar . Klaritsit . Klaritrosin . Clarithromycin . Klaromin et al. Replace the vehicle only after the approval of a doctor, as each of these medications, there are certain features of the use and side effects.
Price analogs can be either higher or lower. Differences Klatsid and Klatsid CP in that the latter product is a long-acting drug, i.e. the active ingredient is released more slowly.
With alcohol
As the instruction Klatsid and alcohol are incompatible. If these antibiotics in the treatment of a patient drinks alcohol, dramatically increases the risk of side effects, as the greatly increased toxicity of drugs.
Klatsid children
Klatsid for children can be applied to the age of three. In most cases, children assigned a suspension Klatsid. Reviews for the children indicate that this drug is quite effective. The price of the suspension is sufficiently high. The dosage for children is as follows: 7.5 mg per 1 kg means weight of the child twice a day. The highest daily dose - 500 mg.
Children who are over 12 years old, is assigned 250 mg (tablets) twice a day. There is evidence that children suffer Klatsid easier than other antibiotics. Therefore, a drug often prescribed for sore throat . bronchitis . pneumonia and others. However, we should not forget that the side effects still occur.
During pregnancy and lactation
There is no precise information on the safety of the treatment klatsid pregnant and nursing mothers. Therefore, the use during gestation and breast-feeding not practiced.
Reviews klatsid
Reviews klatsid found both positive and not too enthusiastic. Many patients say that the antibiotic is effective and significantly accelerates the healing process. But there are also stories that provoke the manifestation of drug side effects, and as a result was forced to choose a doctor for the treatment of another antibiotic.
Parents who gave children the drug, reviews about klatsid also leave different. Equally reviews medical evidence that experts believe that antibiotics are effective and often prescribed to both adults and children.
Price klatsid where to buy
Buy this antibiotic may be in any drugstore, its value depends on the form of release and dosage. Price Klatsid tablets 250 mg on average 650-800 rubles per pack of 10 tablets. Price Klatsid 500 mg is from 800 rubles for a pack of 14 pieces. Cost suspension Klatsid - An average of 380 rubles per 125 ml vial. Price klatsid in Ukraine is 290 UAH per pack of 10 tablets of 250 mg.
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