Retarpen

Description overdue on 20.02.2012

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Natural antibiotic. The active antibacterial agent - benzathine benzylpenicillin . The main component obtained from molds. With regard to microbial cells bactericidal effect. The mechanism of action of the antibiotic retarpen based on the suppression of the process of synthesizing the cell wall of bacteria. It operates protractedly. Effective against gram-positive, spore-forming, anaerobic rods, gram-negative flora, Treponema. Retarpen no effect on staphylococci, penicillinase. Available in a freeze-dried product.

Indications and contraindications:

Retarpen prescribed for diseases caused by streptococcus, Treponema pallidum: syphilis . scarlet fever . quinsy . rheumatism , erysipelas. The drug is indicated for the prevention of postoperative complications. Retarpen does not apply in case of hypersensitivity to benzylpenicillin at hay fever . The drug is contraindicated in bronchial asthma.

Side effect:

Prolonged therapy with retarpen can lead to superinfection . In the treatment may experience headaches, allergic reactions, glossitis, anemia,   stomatitis , Exfoliative dermatitis, arthralgia, fever, anaphylactic shock , Hypocoagulation, leukopenia.

Mode of application:

Retarpen is administered exclusively intramuscularly. In the appointment of two injections do them in different buttocks. For the treatment of of congenital syphilis to children of younger age and newborn is administered 1, 2 million ED monosubstituted or smash into two injection. The primary seronegative syphilis: retarpen administered intramuscularly at a dose of 2, 4 million units. The secondary fresh syphilis seropositive primary syphilis: 2, 4 million units, 7 days repeat injection. Tertiary syphilis: 2, 4 million units, therapy 3-5 weeks. Flambeziya 1-2 injection of 1, 2 million units. Scarlet fever, acute tonsillitis, erysipelas, wound infection: treatment begins with penicillin, then introduced retarpen. Prevention prisutpov articular rheumatism : Im 2, ​​4 million units every 15 days.

Special instructions:

It is unacceptable the introduction of the drug retarpen intravenously or subcutaneously. When accidentally hit of a medicament into the lumen of of the vessel is celebrated violation of of visual perception, transient feeling of depression, of anxiety. To alert syndrome Oigney   aspiration prior to injection is carried out to detect accidental needle of the syringe into the lumen of the vessel. If you suspect syphilis in the treatment of sexually transmitted diseases is conducted serologic, microscopic studies. It is recommended that the period of antibiotic therapy appoint B vitamins for the prevention of fungal infection. If necessary, designate levorin, Nystatin. Failure to comply with the specified terms of therapy, changing the number of self-administered drug retarpen increases the risk of formation of resistance of pathogens.

Drug Interactions:

Aminoglycosides, rifampicin . vancomycin , Cycloserine, cephalosporins and other antibacterial agents have antibacterial synergistic effect . Tetracycline antibiotics, lincosamides, macrolide antibiotics, chloramphenicol and other bacteriostatic drugs have strongly expressed antagonistic effect . Retarpen decreases prothrombin index Inhibits the intestinal microflora, increases efficiency anticoagulants , Significantly affects the effectiveness of hormonal contraceptives. Allopurinol , Diuretics, phenylbutazone, tubular secretion blockers, non-steroidal drugs increase the concentration of penicillin. When concomitant administration of allopurinol increases the risk of allergy in the form of skin rashes.