Friday, August 31, 2018

Orsoten

Description overdue on 04/06/2014

  • Latin name: Orsoten
  • ATC code: A08AB01
  • Active substance: Orlistat (Orlistat)
  • Manufacturer: Krka-Rus (Russia)
Photos of the drug
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  • Composition
  • Product form
  • Pharmacological action
  • Pharmacodynamics and pharmacokinetics
  • Indications
  • Contraindications
  • Side effects
  • Instructions for use Orsotena (method and dosage)
  • Overdose
  • Cooperation
  • Terms of sale
  • Storage conditions
  • Shelf life
  • Cautions
  • Analogs
  • Synonyms
  • Babies
  • Slimming
  • During pregnancy (and lactation)
  • Reviews
  • Price, where to buy

 Orsoten

Composition

The composition of one capsule Orsotena following: it contains 120 mg Orlistat As well as an auxiliary ingredient - microcrystalline cellulose .

Product form

Hard gelatin capsules may have a white to whitish yellow, they contain microbeads or microgranules and a mixture of a white powder. The capsules may contain agglomerates that are very easy to fall apart when they press.

The capsules are contained in a blister pack of 7 pieces in a carton box contains 3, 6 or 12 of the blisters. Also, capsules can be packaged in a blister pack to 21 pieces, cardboard packaging contains 1, 2 or 4 blisters with capsules.

Pharmacological action

Pills Orsoten suspend the process of fat absorption in the intestine. The drug is a part of the active substance Orlistat Which specifically inhibits gastric and pancreatic lipases. The emergence of covalent bonds with stomach   and pancreatic lipase   Orlistat prevents splitting of fats contained in food. When triglycerides are not cleaved from the digestive tract are not absorbed. They are excreted in the feces. As a result, the human body receives fewer calories. Therefore, the summary shows that Orsoten helps to reduce body weight. Thus there is no systemic absorption of the active ingredient.

Pharmacodynamics and pharmacokinetics

At a dose of 60 mg three times a day, the drug being blocked approximately 25% of fat absorption from food.


Already 24-48 hours after ingestion of the drug concentration of fat in the intestinal contents of the intestine increases. If the preparation is canceled, the concentration of fat in the intestine is returned to the same parameters as before his admission, after 48-72 hours.

If the agent takes an adult body mass index of more than 28 kg / m2, at a dose of 60 mg three times a day, its effectiveness is increased by combined treatment with low-calorie diet. Mainly active weight lost in the first six months of treatment.

In addition to reducing the weight of orlistat at a dose of 60 mg three times a day can reduce the content of cholesterol . In addition, people who are drug treatment, noted the decrease in the waist.

According to research, there is minimal absorption Orlistat . When using therapeutic doses of the drug in the blood plasma unmodified orlistat is present only sporadically, wherein its concentration is very low. There are also no signs of accumulation.

Orlistat binds to plasma proteins is greater than 99%. At a minimum, it is able to penetrate into the erythrocytes .

Metabolism   It noted in the walls of the small intestine, and stomach. About 97% of the material discharged through the intestines, including 83% - as persistent orlistat. Kidneys derived only about 2% of the total dose. Full elimination from the body is 3-5 days.

Indications

Orsoten   and Orsoten Plus   is shown to receive people who need to reduce body weight. Assign an adult patients who are overweight (body mass index greater than 28). The drug can be taken only under the low-calorie diet.

Contraindications

Contraindications drug following:

  • High sensitivity orlistat ;
  • chronic malabsorption syndrome   and cholestasia ;
  • childhood and adolescence.

Precautions Orsoten appointed the following diseases:

  • diabetes   the second type;
  • violation of kidney function;
  • hypothyroidism ;
  • epilepsy ;
  • change in the volume of interstitial fluid.

Side effects

With regular use of the capsules may develop some side effects. In most cases this gastrointestinal reactions associated with the pharmacological action of the drug.

  • Digestive system : The appearance of oily secretions nature of the rectum, gassing , Periodic urgency to defecate, abdominal pain, loose stools . scatacratia More frequent bowel movements.
  • Hematopoietic system : Increase in the MHO, a decrease in the concentration of prothrombin .
  • Skin : Appearance bullous rash .
  • Allergic symptoms : hives . rash . itch . bronchospasm . anaphylaxis . angioedema .
  • May exhibit minor rectal bleeding, hepatitis . diverticulitis . cholelithiasis , Elevated liver enzymes.

If you notice any adverse effects, be sure to consult your doctor so that he has determined whether to continue treatment.

Instructions for use Orsotena (method and dosage)

The drug is taken orally in a food or decision for one hour after the meal.

Instructions on Orsoten Slim   He notes that the patient must adhere to a low-calorie diet, where, based on calories contains not more than 30% fat. Food must be spread evenly over three stages. How much time should be a means of how to take Slimming Capsules correctly, as well as individual dosage should be determined by the doctor.

Typically, for adult patients assigned to receive 120 mg of orlistat three times a day, that is, during or after each food intake. If there was no food intake or food does not contain fat, the capsule can not receive.

Orsotena maximum dose a day - 3 capsules. If the drug is taken in a dose exceeding 360 mg per day, its efficacy is not increased, but greatly increases the risk of side effects.

With a decrease in body weight of less than 5% at 12 weeks of therapy Orsotenom should be discontinued.

Even before the start of the drug is recommended to follow diet   and regularly carry out f Physically exercise . Proper nutrition and sport should be practiced, and after stopping capsules.

Overdose

Information about the overdose, as well as adverse reactions, observed as a result of an overdose are not available. If there was a significant overdose Orlistat , It is necessary to consult a doctor. Medical supervision is necessary for such a patient during the day. All of the systemic effects of the active ingredient rapidly reversible.

Cooperation

If at the same time taking cyclosporine   and Orlistat , There is a decrease in the concentration of cyclosporine   in blood plasma. As a consequence, lowers its immunosuppressive activity. Concomitant treatment with these drugs.

Receiving Orlistat   and warfarin   or other oral anticoagulants leads to changes in the value MHO.

Treatment with orlistat leads to malabsorption series fat-soluble vitamins .

It should not be used at the same time Orlistat   and acarbose   in the absence of data on their interactions.

Simultaneous reception Amiodarone   orlistat with a reduced concentration of amiodarone in plasma. Apply these medicines at the same time is possible only after the recommendation of a specialist.

There was no interaction with Orsotena F enitoinom . Atorvastatin . Amitriptyline . Fluoxetine . Phentermine . Sibutramine . Digoxin . Losartan . ethanol , Oral contraceptives, but also pravastatin . biguanidami . fibrates .

Terms of sale

Sold by prescription.

Storage conditions

Store at a temperature of from 15 to 25 degrees Celsius. The drug should be protected from children.

Shelf life

Keep Orsoten can be 2 years.

Cautions

Be sure to focus on the patients that non-compliance with a low-calorie diet and the same time taking capsules likelihood of side effects increases.

If the people who are oral contraceptives   while taking Orsoten, note the appearance of diarrhea They need to use additional methods of protection, in particular barrier.

Multivitamin Orsotenom in the treatment must be taken before bedtime, as Orlistat   impaired absorption of some vitamins.

People taking hypoglycemics Must before treatment slimming capsules be sure to consult your doctor, who will adjust the dose of hypoglycemic drugs.

By reducing the weight of the person can be marked improvements in blood pressure, reduce cholesterol levels. So people taking drugs to lower blood pressure, as well as the means to prevent hypercholesterolemia, while taking Orsotena should consult with your doctor.

If the treatment with orlistat develop rectal bleeding , Be sure to consult with your doctor.

Admission Orsotena does not affect the person's ability to manage the transport or work with the precise mechanism.

Because of the minimal absorption of orlistat to adjust the dose for the elderly and for people suffering from dysfunction of the kidneys and liver, is not necessary.

Analogs

Match code ATC 4th level:
  •  Orsoten  Ksenalten
  •  Orsoten  Orlistat
  •  Orsoten  Xenical

Analogs Orsoten drug - this drug Xenical . Orlistat . Orsoten Slim . Orlimaks . Ksenalten   and others. In the selection of drugs is recommended to always consult a doctor. Guided solely by the cost of the drug should not be. In addition, some drugs have a higher cost. In particular Xenical capsules will cost an average of 900 rubles. 21 capsule, whereas the price of an analogue of Xenical - Orsoten the drug - about 650 rubles per 21 capsule.

Xenical or Orsoten - which is better?

Reviews show that this question is no single answer. The effectiveness of drugs on the body and Orsoten Xenical depends on how correct and regular intake of capsules is, whether the person is engaged in sport, whether it complies with the diet. Both drugs are used for complex treatment of obesity. Both tools include one pharmacological group have similar active substance and are inhibitors of gastrointestinal lipases. Determine what kind of drug is selected will help the doctor, considering the individual characteristics of the person and his problems.

Is it better or Orsoten Reduxine?

Reduxine   - It is a combination tool that provides enterosorbiruyuschee and anorectic effect on the body. As the reviews, Reduxine can significantly reduce appetite, while Orsoten prevents the absorption of fat. Taking into account the different effects of medicines, their choice should be made available only to the expert.

Synonyms

Xenical . Alai .

Babies

Not applicable for the treatment of children and adolescents who are under 18 years old.

Slimming

The drug used to treat obesity .

Asked the difference between Orsoten   from Orsoten Slim It should be primarily borne in mind that the active substance in both preparations is Orlistat . Only different dosage - a capsule Orsoten used 120 mg of active ingredient, and a slim Orsoten - 60 mg. Choosing a drug for weight loss, it should be taken into account for this difference.

During pregnancy and lactation

There are no clinical studies of drug action during pregnancy   and between breast-feeding . Therefore, the means is not used for treating pregnant women and lactating mothers.

Reviews

At various sites and forums are numerous reviews Orsoten slimming. Most reviews Orsoten Slim   and Orsoten Plus   demonstrate the effectiveness of the drug. Reviews lost weight often contain information on how to help a person lose weight kilograms of the drug. As a rule, it is noted that the pills 120mg allow to lose for one month 5-7 kg.

Note that the reviews about losing weight Orsotene Slim   and Orsotene   It indicates that the most effective action of the drug observed when combining it with the reception low-calorie diet. Almost every active forum for slimming holds a discussion of how safe it is slimming. Generally, it is noted that the drug provokes side effects if the person during the treatment does not reduce the usual amount of fats in the diet.

Reviews of Orsotene doctors also largely positive. They approve the drug as an analogue of Xenical, while noting that the reception means it is necessary to practice in compliance with diet and active lifestyle.

Price Orsotena where to buy

The average price Orsotena   Weight loss is 630 rubles - 650 rubles. 21 capsule. Buy in Moscow Orsoten 120 mg (42 capsules) can be the average for 940-1000 rubles. Cost Orsoten Slim   an average of 1700-1800 rubles per pack (84 capsules). Slightly cheaper means to buy internet pharmacy in the presence of stocks and discounts. How much does a pharmacy Orsoten should specify a particular point of sale.

The cost of the drug in Ukraine (21 capsule) is about 430-450 UAH. Belarus Orsoten difficult to buy. As a rule, in Minsk and in other cities of the country must be pre-ordered slimming internet pharmacies. Similarly, you can buy the drug in Kazakhstan.

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