Description overdue on 04/12/2014
- Latin name: Tafen Nasal
- ATC code: R01AD05
- Active substance: Budeconid (Budesonide)
- Manufacturer: Sandoz (Switzerland)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Tafen Nazal (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Single dose nasal spray contains active ingredient 50 mg Budesonide . Additional ingredients: hydrochloric acid, sucrose, polysorbate 80, propyl parahydroxybenzoate, purified water, propylene glycol, microcrystalline cellulose.
Product form
The vials are equipped with special metering device. The vials are made of dark glass and have a tip and nosepiece. Each vial for 200 doses and packed in a cardboard box.
Pharmacological action
Glucocorticosteroid intranasal use. The active substance has a pronounced antiallergic and anti-inflammatory effect . Resorptive effect does not develop when using the drug at therapeutic doses. When long-term therapy budesonide is well tolerated and has no mineralocorticoid activity. The treatment reduces production of inflammatory mediators, and eosinophilic granulocytes mast cells ; increases the production of anti-inflammatory proteins. The active substance reduces the production free radicals , Toxic proteins, and inhibits synthesising histamine That reduces its concentration in mast cells.
Spray can reduce the severity of negative symptoms allergic rhinitis . The positive dynamics recorded in 48 hours.
Pharmacodynamics and pharmacokinetics
After a single inhalation of budesonide maximum level observed after 0, 7 hours and is 1 nmol / l. In the systemic circulation gets only 20% of the active ingredient after intranasal administration. The active ingredient is uniformly and entirely distributed in the tissues by binding to plasma proteins. In budesonide low systemic bioavailability, as resulting in a single-stage metabolism in the hepatic system it is absorbed more than 90% of the active component. In metabolites glucocorticoid activity does not exceed 1%. The drug is excreted in urine and feces.
Indications
Nose drops prescribed for:
- nasal polyps ;
- nonallergic rhinitis genesis .
The drug used for the treatment and prevention of allergic rhinitis (seasonal and perennial forms).
Contraindications
- Tuberculosis of lung tissue ;
- Individual hypersensitivity to budesonide;
- breast-feeding ;
- age limit - up to 6 years.
At pregnancy . Herpes . shingles , Nose injuries, infection of the respiratory system (viral, bacterial, mycotic) Budesonide is used with caution, after consulting relevant specialists.
Side effects
Respiratory tract:
- nosebleeds ;
- rhinorrhea ;
- the formation of cortical formations on the mucous membranes;
- irritation of the nasal cavity;
- pain in the nose;
- characteristic wheezing;
- dyspnea ;
- sneezing ;
- hoarseness.
Rarely recorded dry mucous walls of the throat, allergic responses . itch . hives . candidiasis nasal cavity. Prolonged therapy can lead to perforation of the nasal septum, the appearance of systemic reactions in the form of work adrenal suppression, reduction of bone mineral density, growth retardation Cataract , Manifestations of symptoms giperkotitsizma , Development Glaucoma .
Very rarely observed:
- drowsiness;
- myalgia ;
- anosmia ;
- a sore throat;
- migraine headache ;
- dizziness ;
- stuffy nose, redness of the conjunctiva;
- heartbeat.
Instructions on Tafen Nazal (method and dosage)
Spray is designed for intranasal use.
Instructions for use Tafen Nazal in adults: in each nostril twice daily is administered 2 doses of 50 micrograms. Standard maintenance regimen: 1 dose in each nostril twice a day. Supporting called the lowest effective dose, the ability to cope with symptoms of rhinitis. A single dose should not exceed 200 mcg. Regular and proper use of medication can achieve full therapeutic effect and reduce the severity of adverse reactions.
Before spraying spray is recommended that thorough cleaning of the nasal passages of mucus using saline. The bottle is shaken before each use, and then remove the special protective cap and a small amount of the drug is sprayed into the air by pressing the nozzle. When clogged outlet require rinsing nozzles must not be cleaned using sharp objects, needles.
Overdose
In case of accidental overdose pronounced symptoms are not observed. The development of acute overdose unlikely. Long-term therapy in conjunction with other corticosteroids may cause Cushing's clinical picture. In such cases, the phasing out of the drug.
Cooperation
Reducing the effectiveness of budesonide observed during concurrent therapy inducers of microsomal oxidation:
- Rifampicin;
- Phenytoin;
- Phenobarbital.
The reverse reaction is observed in respect of Ketoconazole . Methandienone . estrogen .
Terms of sale
Buy Tafen Nazal can be a pharmacy by presenting a doctor's prescription form with a stamp.
Storage conditions
Manufacturer's recommended temperature range - up to 25 degrees. Restrict uncontrolled admission of young children.
Shelf life
2 years.
Cautions
Not allow any spray into the eyes. Careful control over the work hypothalamus and pituitary-adrenal axis at the transition from systemic glucocorticoid therapy for treatment of nasal spray. Canceling the drug is carried out smoothly by controlling the hormonal parameters. When dose reduction is recorded:
- depressed mood ;
- apathy;
- pain in joints and muscles.
Glucocorticoids can slow the healing of the wound surfaces. The full therapeutic effect is observed with regular use of a spray. Long-term treatment requires an annual inspection of the nasal mucosa. The children have been reported cases of stunting during treatment with the drug Tafen Nazal.
Analogs Tafen Nazal
Nasobek
Polydex with phenylephrine
Avamys
Fliksonaze
Nasonex
Nazarel
Bekonaze
Structural analogues of the drug:
- Benacort;
- Pulmicort;
- Benarin;
- Budenofalk.
During pregnancy (and lactation)
Tafen at Nazal pregnancy is prescribed in cases where the expected benefits outweigh the possible risks to the fetus. Breast-feeding recommended stop for the entire period of treatment with budesonide.
Reviews Tafen Nazal (overview)
The drug is actively used in pulmonology and allergy. Reviews Tafene indicate high efficiency spray at relieving unpleasant symptoms of allergic rhinitis. Patients say ease of use, duration of action and rapid effect. Doctors prescribe Tafen Nazal actively in their medical practice.
Price Tafen Nazal, where to buy
Price Tafenau depends on pharmacy sales region and ranges from 335 to 420 rubles per bottle.
No comments:
Post a Comment