Description overdue on 10/12/2014
- Latin name: Euthyrox
- ATC code: H03AA01
- Active substance: Levothyroxine Sodium (Levothyroxine sodium)
- Manufacturer: Merck KGaA., Germany.
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- During pregnancy (and lactation)
- Side effects
- Instructions on Eutiroks (method and dosage)
- Overdose
- Cautions
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Eutiroks and weight
- Reviews
- Price, where to buy
Composition
The composition of one tablet includes an active ingredient: levothyroxine sodium - 25-150 md.
Additional ingredients: corn starch, gelatin, croscarmellose sodium, magnesium stearate, lactose monohydrate.
Product form
Eutiroks produced tablets with different content of active substance. The tablets are packed into blisters of 25 pieces, 2 and 4 in the blister pack.
Pharmacological action
The drug has an action capable to fill deficiency of thyroid hormones .
Pharmacodynamics and pharmacokinetics
Eutiroks is a drug based on synthetic levorotatory isomer thyroxine . Its use has an impact on the growth and development of tissues and metabolism.
Small dosages can be an anabolic effect on the fat and protein metabolism. Mean doses cause stimulation of growth and development, metabolism, and normalizes oxygen demand of tissues, as well as the heart, blood vessels and nervous system. The development of a therapeutic effect is manifested after 7-12 days, while maintaining stability during this time, and after discontinuation of treatment.
Absorption levothyroxine sodium It occurs in the small intestine directly into its upper part. Use of food influences the absorption of the active substance, considerably reducing it. The maximum concentration of the component is achieved after 5-6 hours of use.
The main portion of the drug bound to serum proteins. Then thyroid hormones are metabolized primarily in the kidney, liver, brain and muscle tissues. Excretion of metabolites is done by the kidneys and intestines.
Indications
Eutiroks indicated for:
- gipotireoeze;
- euthyroid goiter;
- substitution treatment and prevention of relapse weeks after surgery on the thyroid gland;
- thyroid cancer;
- diffuse toxic goiter;
- diagnostic testing for thyroid suppression.
Contraindications
Taking the drug is contraindicated in case of:
- high sensitivity to its constituent substances;
- nelechёnom hyperthyroidism, pituitary, and adrenal insufficiency;
- pregnancy in conjunction with antithyroid agents.
Do not use Eutiroks for the treatment of patients with acute myocardial infarction, myocarditis and pankardita . The content of lactose in the formulation makes it forbidden to reception of patients with a rare genetic disease related to galactose intolerance, lactase deficiency syndrome or glucose-galactose malabsorption.
Require caution in applying such diseases as: coronary heart disease, hypertension, diabetes, arrhythmia .
Eutiroks during pregnancy and lactation
If the drug was administered for the treatment of hypothyroidism, then when pregnancy and breastfeeding should be continued. Furthermore, pregnancy may require increasing dosages due to increased thyroxine-binding globulin. It is important to adhere strictly to the dosage recommended by the doctor. It was found that taking high doses capable of adversely affect fetal development.
Side effects Eutiroksa
With proper reception of drug side effects substantially do not occur. However, it should not be excluded, such side effects as the various forms of allergic reactions.
Instructions on Eutiroks (method and dosage)
As indicated by the instructions for use Eutiroksa, this medication is taken orally. This daily dose is determined individually, taking into account the indications and patient characteristics.
Take a daily dose is recommended in the morning on an empty stomach. The tablet should be swallowed whole with liquid. When carried out replacement therapy of hypothyroidism, the dosage is determined depending on the weight of the patient. In the treatment of children under 3 years provide a cure before the first feeding, for half an hour. A tablet to be dissolved in water to form a thin slurry.
Heavy and prolonged form hypothyroidism It involves the initiation of treatment with care and in smaller dosages. Thereafter, the dosage is gradually increased up to 25 mg or more. In such cases usually take medication constantly, but strictly prescribed by the attending physician.
Overdose
In case of overdose eutiroks possible a significant increase in the rate of metabolism. This leads to the development of hyperthyroidism And particularly when the threshold is exceeded, the individual tolerability levothyroxine sodium And is too quick to improve the therapeutic dose.
Here overdoses develop symptoms such as: arrhythmia, tachycardia , Heart failure, angina , Muscle and headaches, tremor, flushing, fever , Vomiting, benign intracranial hypertension , Anxiety, insomnia . hyperhidrosis , Reducing the weight and so on.
Implementation of treatment depends on the symptoms manifested. It is possible that the doctor will reduce the daily dose or recommend a break, appoint beta-blockers . As a result of receiving too high doses appointed plasmapheresis . When overdose symptoms are eliminated, the resumption of treatment is carried out with caution, using small doses.
Cautions
Before starting replacement therapy with thyroid hormone and thyroid suppression of the test, should be excluded or conduct treatment of these diseases or abnormalities as acute coronary insufficiency, angina, atherosclerosis, hypertension . failure of the pituitary gland or adrenal insufficiency. This also applies to the functional autonomy of the thyroid gland.
It is recommended to exclude the development of hyperthyroidism during treatment in patients suffering from coronary and heart failure, tachyarrhythmias . For this reason, you should regularly monitor the concentration of thyroid hormones.
If there are suspicions on the occurrence of the functional autonomy of the thyroid gland, it is necessary to perform a pre-treatment of the reaction to the introduction of tireoliberina known as TRH test and suppressive scintigraphy.
Women during menopause diagnosed with hypothyroidism and an increased risk osteoporosis Not permissible high physiological concentrations of active component in the serum. It should regularly monitor the work of the thyroid gland.
Contraindicated use levothyroxine sodium in metabolic disorders accompanied by hyperthyroidism. Exceptions include concomitant use in the treatment of hyperthyroidism with antithyroid agents. In the case of switching to another drug treatment dose adjustment is required in view of the therapeutic effect and laboratory data.
Cooperation
Simultaneous treatment with this drug with tricyclic antidepressants may potentiate their action.
Levothyroxine sodium lowers the effectiveness of cardiac glycosides.
Combination with colestyramine, colestipol, aluminum hydroxide reduces the concentration of active substance in plasma due to the stagnation in the gastrointestinal absorption. So between these drugs is necessary to maintain an interval of 4-5 hours.
Simultaneous use of anabolic steroids and Eutiroksa, asparaginase, tamoxifen It can lead to pharmacokinetic interactions level due to plasma proteins. It is also found that the protease inhibitor, namely ritonavir, lopinavir and indinavir able to influence the effectiveness of this drug. It is necessary to control the concentration of thyroid hormones and conduct timely adjustment of dosage.
Combination therapy with phenytoin often increases the concentration of levothyroxine sodium, accelerating its metabolism. This drug may reduce the effectiveness of hypoglycemic agents and enhance the effect of anticoagulants.
Application to sevelamer It reduces the absorption of the active substance, and tyrosine kinase inhibitors, aluminum-containing, iron supplements and calcium carbonate reduce its effectiveness. At the use of products containing soy marked reduction in absorption of the active ingredient in the gastrointestinal tract.
Terms of sale
Eutiroks prescription.
Storage conditions
To store the drugs needed a cool, dark place away from children.
Shelf life
3 years.
Analogs
Major drug analogues presented With L-thyroxine and Levothyroxine sodium . Also, have a similar effect: Tireoidin and Triiodothyronine hydrochloride.
Alcohol
As is known, the drug is a natural thyroid hormone. For this reason, to drink alcohol with eutiroks not recommended.
Eutiroks and weight
Many women suffering from disorders of the thyroid gland, worried about the question whether the treatment eutiroks increase weight. But the reviews have shown that the use of hormones in different ways affects both the weight of the patients and their general condition. Therefore, it raises some women, while in others - is reduced.
For this reason, some people think that you can use Eutiroks slimming, especially when a number of hormones really be used to adjust the mass of the body, such as athletes. However, experts say that Eutiroks slimming without specific to this testimony should not be accepted. Sometimes reviews for weight loss have reported successful cases, but is usually a way to eliminate excess weight leads to serious abnormalities in the body.
Reviews eutiroks
As the reviews eutiroks, this drug is often used in clinical practice as a violation of the thyroid gland trouble many patients.
Basically reviews Eutiroks 50 micrograms report that this is the dosage used in the treatment of many diseases. However, it is important to start treatment with low doses, such as 12, 5 g, and then increased to 25 mg and so on. The main thing - to do it gradually.
A large number of questions arise in patients that the drug has been appointed recently. Therefore, they are interested in how to take pills and Eutiroks - hormonal drug or not? It is also concerned about women, whether during the treatment develop various side effects and whether it can be used for weight loss?
Often, patients who take the drug, according to its good tolerability and a minimum of side effects. Of course, important conditions are: strict adherence to dosing, on-time delivery of tests and lifestyle changes.
Unfortunately, you can find the message in which patients report that continue to experience severe pain, drowsiness, depression. It is also noted that some reduced or increased weight. In any case, all the issues should be discussed with your doctor, which will replace medication or adjust the dosage.
Price Eutiroksa where to buy
Price Eutiroks 50 mcg for 50 pieces of pharmacies in Moscow is 130-150 rubles.
Buy Eutiroks 50 micrograms may be the online pharmacies at a cost of 106-130 rubles.
Price Eutiroks 100 mg varies between 117-150 rubles, and Eutiroks 25 micrograms can be bought for 86-100 rubles.
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