Description overdue on 10/17/2014
- Latin name: Floracyd
- ATC code: J01MA12
- Active substance: Levofloxacin (Levofloxacin)
- Manufacturer: OAO Valenta Pharmaceutica, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Floratsida (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
One tablet contains 250 or 500 mg of active substance - levofloxacin + Additional ingredients (crospovidone, sodium lauryl sulphate, MCC, magnesium stearate, povidone, colloidal silica, partially hydrolised polyvinyl alcohol, macrogol 3350, yellow iron oxide colorant, talc, a colorant red ferric oxide, titanium dioxide, Opadry II).
Product form
The drug produced in the form of elongated, biconvex tablet, pale pink, film-coated, scored on one side. If you cut the pill in half, on a section clearly shows the two layers. The drug is sold in packs of 5 or 10 pieces.
Pharmacological action
Antibacterial broad spectrum.
Pharmacodynamics and pharmacokinetics
Floratsid - an antibiotic or not?
Active substance means - antibiotic broad-spectrum band fluoroquinolones . It laevorotatory isomer ofloxacin .
The substance blocks the enzymes topoisomerase 4 and topoisomerase 2 molecule DNA vredononsnogo agent. Thus broken processes supercoiling and synthesis DNA Arise irreversible destructive changes cytoplasm the cell and its membrane.
The drug has a wide antibacterial spectrum. As a result, studies have shown that the antibiotic is active in vivo against: Escherichia coli, Staphylococcus aureus, Moraxella catarrhalis, Providencia rettgeri, Legionella pneumoniae, Enterobacter aerogenes, Enterococcus faecalis, Streptococcus pyogenes Viridans group streptococci, Enterobacter sakazakii, Enterobacter cloacae, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Haemophilus parainfluenzae, Pseudomonas fluorescens, Mycoplasma pneumoniae, Acinetobacter baumannii, Bordetella pertussis, Citrobacter freundii, Klebsiella oxytoca, Proteus vulgaris, Providencia stuartii , Clostridium perfringens, Streptococcus pneumoniae, Enterobacter agglomerans, Streptococcus agalactiae, Pseudomonas aeruginosa, Chlamydia pneumoniae, Acinetobacter calcoaceticus, Citrobacter diversus, Staphylococcus epidermidis, Morganella morganii, Acinetobacter anitratus, Serratia marcescens .
Effectively in vivo with respect to:
- aerobic Gram-positive organisms (Enterococcus spp., Staphylococcus spp. Staphylococcus spp. Corynebacterium diphtheriae, Streptococcus spp., etc.);
- aerobic gram-negative organisms (Acinetobacter spp., Eikenella corrodens, Gardnerella vaginalis, Helicobacter pylori, Neisseria gonorrhoeae Neisseria meningitidis, Providencia spp., Pasteurella spp. Actinobacillus actinomycetemcomitans, Enterobacter spp., etc.);
- anaerobic microorganisms (Bacteroides fragilis, Fusobacterium spp., Propionibacterium spp., Bifidobacterium spp., Peptostreptococcus spp., Veillonella spp., etc.);
- other microorganisms (Bartonella spp., Chlamydia trachomatis, Mycobacterium spp. Mycoplasma hominis, Ureaplasma urealyticum, Rickettsia spp., Chlamydia psittaci, Legionella spp.).
Levofloxacin It shows a moderate activity Corynebacterium urealyticum, Enterococcus faecium, Staphylococcus haemolyticus Campylobacter jejuni, Bacteroides thetaiotaomicron, Bacteroides ovatus, Porphyromonas spp. Corynebacterium xerosis, Staphylococcus epidermidis Burkholderia cepacia, Campylobacter coli, Bacteroides vulgatus, Prevotella spp.
Corynebacterium jeikeium, Staphylococcus spp. Alcaligenes xylosoxidans, Mycobacterium avium, Staphylococcus aureus resistant to the drug.
Food intake does not affect the absorption of the antibiotic. It is rapidly and completely absorbed through gastrointestinal tract It reaches maximum concentration in the plasma after 1, 3 hrs. The half-life - 7 hours. Up to 40% bound to plasma proteins. Penetrates urinary system . cerebrospinal fluid . alveoli , Sputum and bronchial mucosa. In the liver, the drug is oxidized.
About 80% of the drug is excreted by the kidneys within two days, a small amount - through the intestines (three days).
Indications
The tool is prescribed for diseases caused by the pathogens susceptible to antibiotic :
- in chronic bronchitis in the acute phase;
- pyelonephritis and other infections of the urinary tract and kidneys are usually complicated;
- prostatitis bacterial etiology;
- at intra-abdominal infections ;
- in acute sinusitis ;
- pneumonia ;
- urinary tract infections;
- for the treatment of infections of skin and soft tissues;
- in complex therapeutic treatment of resistant forms TB .
Contraindications
The tool is contraindicated:
- at epilepsy ;
- allergies on levofloxacin ;
- during pregnancy and Lactation ;
- children and adolescents;
- in lesions of the joints caused by the quinolones ;
- Hypersensitivity to the media quinolone series .
Caution must be exercised when taking the elderly and deficit glitch-6 phosphate dehydrogenase .
Side effects
Adverse reactions that appear most frequently:
- diarrhea , Increased levels of liver enzymes and, nausea and vomiting (10% of cases);
- In 1% of cases occur: itching skin and redness, pain epigastric area, loss of appetite, dyspepsia . drowsiness . headache . dizziness . leukopenia . asthenia and eosinophilia .
Rarely, very rarely show:
- hives . swelling . anaphylactic reactions . vasculitis . suffocation . bronchospasm ;
- dysbiosis . hepatitis , Blood in the stool, hypoglycemia ;
- depression . hallucinations . convulsions , Confusion, distortion of taste and smell, hearing loss and vision;
- tachycardia , Vascular collapse , A strong decrease Blood Pressure ;
- tendinitis . myalgia , Pain in muscles and joints, arthralgia ;
- abnormalities in the kidneys, increasing creatinine in blood;
- neutropenia . hemorrhage . agranulocytosis . thrombocytopenia ;
- fever and sensitivity to light.
In some cases, have been reported: Stevens-Johnson syndrome . erythema . Lyell's syndrome Lengthening QT interval . rhabdomyolysis . pancytopenia and hemolytic anemia .
Instructions for use Floratsida (method and dosage)
Means are inside. Drink better tablets before eating or during, without chewing, drinking plenty of fluids.
The duration of the reception and the daily dose should be determined by the doctor depending on the nature and severity of the disease, the sensitivity of microorganisms to antibiotic .
According to the instructions on Floratsid for patients with normal renal function:
- treatment Urinary tract infections means taking 250 mg, 3 to 10 days depending on the severity of the disease;
- at sinusitis administered at 500 mg per day for 10-14 days;
- at prostatitis - 500 mg per day, 28 days;
- during exacerbation chronic bronchitis Take 250-500 mg of the antibiotic in the day, the course - 7-10 days;
- treatment skin infections and the subcutaneous layer appoint 250-1000 mg per day, 7-14 days;
- at pneumonia - From 500 to 1000 mg per day, one or two weeks;
- for resistant forms TB - 500 or 1000 mg agent, 90 days, in combination with other agents;
- at intra-abdominal infections 500 mg administered one to two weeks.
After the Hemodialysis or continuous ambulatory peritoneal dialysis administering additional doses are required.
Treatment antibiotic It continues for at least two days after the normalization of the temperature and reducing the amount of bacteria .
For those with kidney zaboelvaniya:
- if the indicator KK reaches 10-19 ml per minute, it is possible to take 125 mg of 1 or 2 times a day, or once every two days;
- if KK 20-50 ml / min appoint 125-250 mg 1-2 times a day;
- if KK less than 10 ml / min, the maximum daily dose - 125 mg.
Overdose
Symptoms of overdose are: confusion . convulsions . nausea . tachycardia . dizziness . erosion gastric mucosa.
As the therapy treatment developed symptoms dialysis ineffective antidote no. It is recommended to consult a doctor.
Cooperation
When combined with NSAIDs and theophylline It increases the risk of seizures.
Formulations containing iron, sucralfate . magnesium-containing antacids, reduce efficiency levofloxacin .
The risk of tendon rupture is significantly increased while taking the antibiotic GCS .
The drug does not interact with calcium carbonate .
The half-life is extended by the action of the means cimetidine and probenecid .
Various antagonists Vitamin K may affect blood clotting should be to make the control of blood parameters.
Terms of sale
Requires a prescription.
Storage conditions
Store in a dry, dark place at room temperature.
Shelf life
2 years.
Cautions
Not recommended intake levofloxacin alcohol.
Elderly patients often have abnormalities in the kidneys, to appoint a means for them to be cautious.
After stroke or severe brain injury increases the risk of seizures while taking antibiotic .
Before the drug should not be long under intense ultraviolet light, such as sun, to avoid hypersensitivity reactions.
If you suspect on pseudomembranous colitis , Treatment should be stopped immediately, do not use drugs, which suppress the motility GI .
During treatment pneumonia Induced pneumococci and other diseases caused by Pseudomonas aeruginosa Further aids should be prescribed to combat the disease.
During the reception Floratsida is not necessary to control mechanisms and machines due to lower concentration.
Keep in mind that:
- patients with an enzyme deficiency glucose-6-phosphate dehydrogenase may hemolysis ;
We need to control blood clotting, in combination with drug vitamin K antagonists; - in the elderly increases the likelihood tendinitis .
Analogs Floratsida
Glewe
Avelox
Fleksid
Levolet P
Norbaktin
Tsiprinol
Ofloksin
TSifran
Tavanic
Nolitsin
Ofloxacin
The analogy with the same active ingredient: Glewe, Levofloks , Lebel, Levofloksabol, Ivatsin, Leflobakt, Levotek, Levostar, Levofloxacin, Leobeg, Lefoktsin, Maklevo, tavanic, Fleksid, Ekolevid, Tanflomed, Elefloks .
Reviews Floratside
The antibiotic has good reviews. Most reports described improvements after urogenital infections ( cystitis, urethritis, prostatitis ), Improvement comes on the second day of receiving funds. Adverse reactions are rare, mainly due to incorrect reception means or in combination with alcohol.
Be aware that levofloxacin - Strong antibiotic, it can not be taken without consulting a doctor.
Price Floratsida where to buy
Price Floratsida 500 mg is about 520 rubles for 5 tablets, and 720 rubles per 10 pieces.
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