Sibazon

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Tranquillizer , Having anxiolytic effects . Active ingredient - diazepam It belongs to the class benzodiazepines . The drug has anticonvulsant, sedative-hypnotic, central muscle relaxant effect. The principle of operation is based on the stimulation of benzodiazepine receptors. Anxiolytic effect is provided by the action of the drug on the amygdala, located in the limbic system. The drug reduces the severity of fear, concern, anxiety, emotional stress. Due to the effects of non-specific thalamic nuclei and the reticular formation in the brainstem provided sedation , Reduces the severity of symptoms of neurotic origin (fear, anxiety).

The oppression of the cells of the reticular formation in the brainstem provide hypnotic effects . Increased presynaptic inhibition is an anticonvulsant effect. The drug inhibits the spread of epileptogenic activity, without affecting the excited state of the hearth. Braking polysynaptic afferent inhibitory spinal tract causes muscle relaxant effects   central genesis. The drug may cause a drop in blood pressure, to expand the lumen of the coronary vessels. Sibazon increases the pain threshold. The drug is able to inhibit the parasympathetic, sympathadrenalic and vestibular paroxysms. The drug reduces the production of gastric juice at night. The efficacy is recorded on days 2-7 of therapy. In chronic alcoholism, abstinence syndrome diazepam reduces the severity of negativism, tremor, agitation, hallucinations , Delirium tremens. Patients with arrhythmias cardialgia, paresthesias therapeutic effect observed by the end of the first week. Buy Sibazon can be in the form of pills, a solution, a tablet dosage form.

Indications:

Drug Usage Sibazon recommended to prescribe the drug for all forms of anxiety disorders. The drug is effective in insomnia . dysphoria   (combination therapy), spastic conditions (compared to lesions of the brain, the spinal cord: athetosis, cerebral paralysis , Tetanus), and spasm of skeletal muscles, rheumatic pelvispondiloartrite, arthritis, bursitis, myositis, progressive chronic polyarthritis , Vertebral syndrome, tension headaches, angina. The drug is prescribed for alcohol withdrawal syndrome: agitation, tension, anxiety, transient reactive state, tremor. When psychosomatic disorders in gynecological practice, gestosis, status epilepticus, ulcers of the digestive system, hypertension, eczema drug is prescribed in the complex therapy. The drug is used in the poisoning of drugs, when Meniere's disease As a premedication prior to endoscopic intervention, surgery under general anesthesia. The drug is used for the relief of epileptic seizures, paranoid-hallucinatory states , Motor excitation in psychiatric and neurological practice in premature detachment of the placenta, to facilitate labor.

Contraindications:

Sibazon not prescribe diazepam intolerance at   Acute intoxication   other medicines in acute alcohol intoxication with the defeat of the vital organs in the form of closed-angle glaucoma, myasthenia, pregnancy, in severe COPD, with absences, acute respiratory failure, breastfeeding. The elderly, with a history of seizures and epilepsy in spinal and cerebral ataxia, hepatic or renal insufficiency, with organic brain disease, when Sleep apnea , The propensity to abuse of drugs, with a history of drug dependence Sibazon used with caution.

Side effect:

Use of the drug Sibazon, especially at the initial stage of treatment, may cause various side reactions. Nervous system: ataxia , Decreased ability to concentrate, poor motor coordination, disorientation , Blunting of emotions, fatigue, dizziness, sleepiness, slowing of motor and mental reactions, unsteady gait, ecmnesia . euphoria , Catalepsy, depressed mood, tremor of limbs, depressed mood, weakness, confusion, euphoria, myasthenia gravis during the day, headache, paradoxical reaction, ataxophemia . hyporeflexia , Irritability, severe agitation, hallucinations, muscle cramps, suicidal tendencies, anxiety, psychomotor agitation, outbursts of aggression, insomnia, anxiety, uncontrollable body movements. The digestive tract:   loss of appetite, vomiting, nausea, dry mouth, constipation, jaundice, increased liver enzymes, hyperptyalism . Bodies of blood:   neutropenia, leukopenia, anemia, agranulocytosis , Thrombocytopenia. Cardiovascular system:   when administered parenterally marked drop in blood pressure, tachycardia, palpitations. Urogenital: dysmenorrhea , Violation of libido, disturbances in the renal system, urinary retention. Perhaps the development of allergic reactions such as itching, rashes. Description Sibazon effect of the drug on the fetus in the treatment of the mother during gestation pregnancy: the suppression of sucking reflex in newborn infants, disorders of the respiratory system. The site of administration of the medicament may develop venous thrombosis or phlebitis, swelling and redness at the injection site. Other reactions: violation of visual perception in the form diplopia , Weight loss, disturbance of respiratory function, respiratory center depression, bulimia, weight loss. With a sharp lifting or lowering the dose of medication developed a syndrome of "cancellation", which is manifested by anxiety, irritability, depression, sweating, depersonalization , Dysphoria, insomnia, nervousness, smooth muscle spasm, acute psychosis, hallucinations, convulsions, sleep disorders, headache, hyperacusis, photophobia, paresthesia, perception disorder, tremor. Use of the drug Sibazon gynecological, obstetric practice: in preterm and full-term infants noted dyspnea, hypothermia , Muscular hypotension.

Overdose:

Higher doses of the drug causes a decrease in reflexes, paradoxical excitement , Confusion, drowsiness, deep sleep, decreased response to pain stimuli, stunned, arefleksiya , Bradycardia, tremor, visual perception, depression of the respiratory and cardiovascular systems, nystagmus, collapse, coma. It is recommended that the appointment of enterosorbents, gastric lavage, carrying out artificial respiration, if necessary, to maintain the level of blood pressure and respiration parameters. Specific antagonist is flumazenil Which applies only in a hospital. Flumazenil - an antagonist of benzodiazepines is not recommended for patients with   epilepsy Which take benzodiazepines because of the risk of epileptic attacks provocation. Hemodialysis is not proven effective.

Mode of application:

Sibazon administered intravenously, intramuscularly, rectally and inwardly .  Dosing of the drug is dependent on the sensitivity to medications, clinical picture, individual response .  In psychiatric practice: with phobias, states of dysphoria, hypochondriacal and hysterical reactions, nervousness medication administered 2-3 times a day for 5-10 mg .  As anxiolytics diazepam taken 2-4 times daily for 2, 5-10 mg .  In some cases the amount of drug can be increased to 60 mg per day .  In the case of alcohol withdrawal syndrome drug administered in the first day, 3-4 times a dose of 10 mg, the amount of medicament further reduced by half .  Patients with atherosclerosis, the elderly and persons with weakened immune systems diazepam administered twice a day for 2 mg .  In practice, neurological degenerative diseases, spastic states of central origin Sibazon take 2-3 times a day for 5-10 mg .  In rheumatology and cardiology: arterial hypertension - 2-3 times a day for 2-5 mg for angina - 2-3 times a day for 2-5 mg, if the vertebral syndrome - 4 times a day to 10 mg .  The drug is used in the complex therapy in the treatment of myocardial infarction: initial dose - 10 mg intramuscularly, further inwards 1-3 times a day for 5-10 mg .  When defibrillation as sedation drug is administered in divided doses by slow intravenous injection of 10-30 mg .  Pi spastic states of rheumatic origin and vertebral syndrome: the initial amount of the drug - 10 mg intramuscularly, then oral 1-4 times a day, 5 mg .  In gineoklogicheskoy practice and obstetrics: menstrual and menopausal disorders, psychosomatic diseases, preeclampsia is shown receiving diazepam 2-5 mg 2-3 times a day .  The initial dose is 10-20 mg preeclampsia intravenous, oral more three times a day for 5-10 mg .  Uninterrupted treatment is carried out at a premature detachment of the placenta before the full maturation of the fetus .  Premedication in surgery and anesthesiology: before surgery provide 10-20 mg of diazepam .  Pediatrics: spastic states of central origin, with jet and psychosomatic disorders gradually increase the amount of drug .  In severe recurrent seizures, status epilepticus Sibazon take parenterally: children under five years of slow intravenous injection 0, 2-0, 5 mg every 2-5 minutes, maximum - 5 mg .  Spinal cord injury, accompanied by hemiplegia or paraplegia, chorea drug is administered intramuscularly 10-20 mg .  When the motor excitation medicament is administered intravenously or intramuscularly three times a day, 10-20 mg .  For relief muscle spasm   (severe form) once the drug is administered intravenously at a dose of 10 mg.

Special instructions:

The price of the drug Sibazon varies depending on the pharmacy network. Intravenous infusion of diazepam is conducted slowly, preferably in a large vein at 5 mg (1 ml) per minute. Intravenous infusion incessant unacceptable because of the risk of precipitation, adsorption of the drug. During therapy Sibazonum requires a complete rejection of the use of alcoholic beverages. In severe renal and hepatic pathology systems require regular monitoring of performance liver enzymes   and peripheral blood picture. Long-term therapy with high doses of the drug forms of drug dependence. Long-term treatment is carried out in exceptional circumstances. Sudden discontinuation of the drug leads to syndrome "cancel" Which manifests confusion, anxiety, myalgia, headaches, stress, hyperacusis , Depersonalization, derealization, tactile hypersensitivity, photophobia, seizures, hallucinations. If during treatment, patients have unusual reactions such as anxiety, increased aggression, thoughts suicide , Insomnia, sleep surface, increased muscle cramps, hallucinations, acute state of excitement the drug overturned. In the first days of therapy, as well as the abrupt cancellation of medication in patients with seizures and epilepsy have a history of seizures and to accelerate the development of status epilepticus. During gestation pregnancy diazepam may be appointed only "life" readings, in exceptional cases. Application sibazon in the first trimester of pregnancy increases the likelihood of congenital malformations And also has a strong toxic effect on the fetus. Use of the drug in late pregnancy leads to inhibition of the central nervous system in newborns. At constant reception during gestation pregnancy marked the formation of physical dependence, sometimes recorded syndrome "cancel" in newborns. Young children are most susceptible to the effects of benzodiazepines in the depressant activity of the central nervous system. Not recommended to prescribe drugs to newborns, as part of which contains benzyl alcohol, because of the risk of fatal toxic syndrome manifested difficulty breathing, depression of the central nervous system, metabolic acidosis , Fall in blood pressure, intracranial hemorrhages , Seizures, kidney failure. If you use diazepam for 15 hours until delivery at doses exceeding 30 mg, can develop sleep apnea, respiratory depression in the newborn, hypothermia, weak act of sucking, drop in blood pressure, decreased muscle tone, a syndrome of "floppy baby," a violation of the metabolic processes in response on Kholodov reaction . Sibazon affect the driving, the performance of hard work. Buy Sibazon possible in the pharmacy network upon presentation of a prescription, the medical form.

Drug Interactions:

Sibazon increases the severity of a depressing effect on the central nervous system Antidepressants , Antipsychotics, sedatives, antipsychotic medications , Muscle relaxants, drugs for general anesthesia, narcotic analgesics. Strengthening actions and the half-life extension is registered while taking a valproic acid , -propoxyphenyl, propranolol , Metoprolol, ketoconazole, isoniazid, fluoxetine, disulfiram, erythromycin, oral contraceptives, cimetidine and other inhibitors of microsomal oxidation. The effectiveness of the drug is reduced when taking inducers of microsomal liver enzymes. The increase in psychological dependence and increased euphoria registered at a joint reception narcotic analgesics   Antacids drugs do not affect the completeness of absorption of diazepam, but reduce the rate of absorption .  When receiving gipotenizvnyh means there is a growing expression of lowering blood pressure .  Concomitant use of clozapine increases depression of respiratory function .  As a result, competition for protein binding increases the risk of digitalis intoxication when using low polarity of cardiac glycosides .  In patients with Parkinson's while taking diazepam decreases levodopa effektovnost .  Withdrawal times lengthened medicament for the treatment of omeprazole .  Drug activity is reduced by the use of stimulants, analeptics, MAO inhibitors .  Sibazon can increase the toxicity of zidovudine .  Theophylline distorts and reduces the sedative effect of the drug .  Rifampin reduces the concentration of active substance, increasing its excretion .  Sibazon incompatible with other medicines, which prohibits the mixing of the drug with other drugs in the same syringe .