Friday, September 29, 2017

Klenzit

Description overdue on 02/10/2014

  • Latin name: Klenzit
  • ATC code: D10AD03
  • Active substance: Adapalene (Adapalene)
  • Manufacturer: Glenmark Pharmaceuticals Ltd. (India)
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  • Composition
  • Product form
  • Pharmacological action
  • Pharmacodynamics and pharmacokinetics
  • Indications
  • Contraindications
  • Side effects
  • Instructions for use (method and dosage)
  • Overdose
  • Cooperation
  • Terms of sale
  • Storage conditions
  • Shelf life
  • Cautions
  • Analogs
  • Synonyms
  • During pregnancy (and lactation)
  • Reviews
  • Price, where to buy

 Klenzit

Composition

1 g of gel contains 1 mg   Adapalene   - Active substance.

Auxiliary ingredients:

  • propylene glycol;
  • disodium edetate;
  • methyl parahydroxybenzoate;
  • Carbomer 940 (Carbopol 940);
  • phenoxyethanol;
  • sodium hydroxide;
  • poloxamer 407;
  • purified water.

Product form

The drug is available in a gel form for topical application.

Package 1 comprises a tube 0, 1% gel 15 g or '30

Pharmacological action

Anti-inflammatory, komedonoliticheskoe.

Pharmacodynamics and pharmacokinetics

The drug is a topical gel designed to treat Klenzit acne.   The active ingredient of the drug is retinoid derivative - adapalene exhibits anti-inflammatory activity and komedonoliticheskuyu. Adapalene   It is involved in the normalization process epidermal differentiation and keratinization , Inhibits the formation of microcomedo   and reduces symptoms inflammation.

The mechanism of action of the active drug substance Klenzit lies in its ability to influence the specific gamma-cell receptors the epidermis of the skin,   lowering their pin surface in the mouths of sebaceous hair follicles.


Studies in vivo and in vitro have shown that Adapalene has a pronounced anti-inflammatory effect, due to its effect on inflammatory factors. Inhibits metabolism of arachidonic acid, and leukocyte migration.

At external application of gel   systemic absorption   its active substance Adapalene is rather low, about 4% of the dose used.

From the systemic circulation, liver output.

Indications

Acne (acne).

Contraindications

  • adapalene hypersensitivity to the drug and other ingredients;
  • period Lactation ;
  • period pregnancy .

Use caution when eczema and dermatitis.

Side effects

Treatment with the gel Klenzit generally well tolerated. In rare cases redness, irritation, flaking skin.   In the event of these complications is recommended to temporarily stop therapy, resumption after the disappearance of these effects.

Described isolated cases of development allergic reactions Which were the reason for the complete withdrawal of treatment.

Instructions for use (method and dosage)

The drug is used only locally (topically).

Before applying the gel, manual Klenzit recommends thoroughly clean and dry problem areas of the facial skin.

Light touch evenly distribute the gel on the surface of the affected acne.   Apply medication Klenzit should be 1 time per day, preferably in the evening, while trying not to hurt the nose and the mouth, eyes and mucous.

The therapeutic effect observed after 1-2 months after treatment initiation and reaches a persistent positive effect after 3 months of therapy.

In rare cases, due to the passing irritation of the skin , Treatment may be suspended until the symptoms disappear irritation.

After consultation with the attending physician may re-appointment of therapy.

Overdose

For external use drug overdose is unlikely.

In case of accidental inner gel receiving standard therapy with gastric lavage and appointment enterosorbents.

Cooperation

When applying medicament Klenzit night, allowed the use of other anti-acne drugs on the following morning.

The simultaneous use of the gel Klenzit and funds from dried and irritating properties (cologne, alcohol or solvents) is not recommended.

It allowed a joint appointment with Benzoyl peroxide and clindamycin.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

24 months.

Cautions

In case of accidental contact of the drug in the mouth and nose and the mucous eye must carefully rinsed with warm water.

Are advised to avoid the effect of direct sunlight on the skin coated with a gel, because of the possible development of skin irritation.

Analogs

Match code ATC 4th level:
  •  Klenzit  Effezel
  •  Klenzit  Retinoic ointment
  •  Klenzit  Retin A
  •  Klenzit  Radevit
  •  Klenzit  Videstim

Analogs Klenzit preparation that can replace it in case of individual sensitivity to its active ingredient:

  • Izotreksin;
  • Aknestop;
  • Videstim;
  • Radevit;
  • Effezel;
  • Retinoic ointment.

Synonyms

  • Adapalene;
  • Differin;
  • Adaklin;
  • Adolat.

During pregnancy (and lactation)

Application Klenzita during pregnancy and breastfeeding is contraindicated.

Reviews Klenzite

Exchanging glances various pages of sites dedicated to the problem of the face and in particular acne (acne)   it may be noted that considering the local remedies to help get rid of pimples, reviews about Klenzite mostly positive. Of course, if you want to overcome this problem at one time, this drug is not for you. The treatment process is quite long (lasting effect occurs after 3 months of use) and requires additional effort on the care of skin, as after application of the drug is often dry skin that needs watering. Gel Klenzit very economical therapy and its use allows for parallel use, after a break, other dermatological agents. It should be noted that not everyone is suited Klenzit, so before you start treatment acne consult a dermatologist, who in the event of any contraindications may designate an appropriate analogue.

Unlike Klenzit and Klenzit With

The main difference between these drugs is that the gel Klenzit C comprises besides Adapalene It is retinoid metabolite . bacteriostatic antibiotic - Clindamycin Active in relation to the purulent inflammation caused by certain Gram-positive cocci.

In therapy acne Provided positive reactions to Adapalene and clindamycin , It is best not to choose between drugs Klenzit Klenzit or C, and to apply them in the overall treatment. Initially, about 2 weeks use Klenzit C, then switch to the application Klenzita.

Price Klenzita where to buy

Price gel in pharmacies in Russia is about 15 grams - 350 rubles and 30 g - 500 rubles.

Price Klenzita kolleblitsya in Ukraine at the level of 340 hryvnia per 15 grams and 450 hryvnia for '30

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