Description overdue on 04/07/2014
- Latin name: Texamen
- ATC code: M01AC02
- Active substance: Tenoxicam (Tenoxicam)
- Manufacturer: Turkish company «MUSTAFA NEVZAT ILAC SANAYII»
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Teksamena (spectrum use)
- Contraindications
- Side effects
- Instructions for use Teksamena (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In each tablet contains 20 mg of active ingredient Tenoxicam .
Excipients: pregelatinized starch, talc, lactose, magnesium stearate.
The tablets are covered with a protective film consisting of yellow iron oxide, hydroxypropyl methylcellulose, titanium dioxide and polyethylene glycol 400 .
Each bottle It contains 20 mg Tenoxicam and optional ingredients: magnesium edetate, sodium hydroxide, mannitol, sodium metabisulfid, trometamol.
Product form
The medicine available in vials as a freeze-dried product with a solvent and in tablet form. In each carton pack is 1 bottle or blister with 10 pills.
Pharmacological action
Analgesic. Active component refers to oxicams and has anti-inflammatory, antipyretic, analgesic effects. The basic principle is based on the effects of braking speed synthesizing prostaglandins , Slowing down metabolism arachidonic acid, cyclooxygenase inhibition. A Teksamen slow release histamine and speed phagocytosis That can reduce inflammation.
The medicament reduces the effects of bradykinin receptors slows output makroenergeticheskih compounds stabilize lysosomal membranes, reducing capillary permeability.
Pharmacodynamics and pharmacokinetics
The active substance is rapidly and fully absorbed in the digestive system. The bioavailability reaches maximum numbers - 100%. The highest concentration is recorded 2 hours after receiving the pills in the body. Almost 99% of the active ingredient is bound to plasma proteins. Metabolism is via the hepatic system. The metabolites are excreted in the bile and urine. Tenoxicam able to cross the blood-placenta (during pregnancy), the blood-brain barrier.
Indications Teksamena (spectrum use)
The drug is intended for patients suffering from degenerative diseases of the musculoskeletal tissue genesis of inflammatory pain syndrome:
- rheumatoid arthritis ;
- gout ;
- osteoarthritis ;
- ankylosing spondylitis ;
- osteochondrosis .
Indications shots: rapid relief expressed pain when:
- traumatic injuries;
- tendinitis ;
- myositis ;
- defeat ligamentous apparatus;
- polyarthritis ;
- lumbago ;
- periatrite ;
- neuralgia .
Contraindications
- individual hypersensitivity to Teksamenu;
- lactose intolerance;
- "Aspirin triad" history;
- Pathology of the digestive tract ( gastritis . peptic ulcer );
- diseases of liver;
- diabetes ;
- heart failure ;
- hypertonic disease ;
- violation coagulation ;
- pathology of the vestibular apparatus;
- violations of auditory perception.
The drug is not indicated in pediatric patients.
Side effects
The digestive tract:
- heartburn ;
- flatulence ;
- gastropathy;
- epigastric pain;
- violations of the chair;
- anorexia ;
- stomatitis ;
- erosive lesions ;
- increase in ALT, AST;
- vomiting.
Blood system, the cardiovascular system:
- thrombocytopenia ;
- increase blood pressure ;
- agranulocytosis ;
- tachycardia .
Nervous system:
- hypersomnia;
- depression ;
- migraine;
- dizziness ;
- hyperexcitability;
- eye irritation;
- noise in ears;
- changes in auditory and visual perception.
Rarely recorded allergic responses . bronchospasm , Itchy skin, angioedema . hyperhidrosis , Increased BUN.
Teksamen injections are well tolerated, rarely cause systemic reactions.
Instructions for use Teksamena (method and dosage)
Tablets for oral use. Standard treatment regimens: 20 mg daily.
Acute gout: 2 tablets of 20 mg 1 time per day for 2 days, then 1 tablet a day. The drug can take 7-14 days.
Pronounced pain syndrome It is encouraged to nominate injections Teksamena . Instructions for use: 1 bottle intramuscular injection of 20 mg daily. Tenoxicam ampoules may be used no more than 5 days.
Overdose
High doses can cause vomiting, stool disorders, epigastric pain, agitation or drowsiness. In severe cases gastrointestinal bleeding . convulsions , Disorientation. Specific antidote not designed posindromnaya recommended therapy.
Cooperation
Salicylates corticosteroid agents and preparations of NSAIDs increases the likelihood of ulceration of the stomach wall. The drug potentiates the effect of sulfonylureas, anticoagulants indirect effects. In its turn probenecid accelerates elimination of the active substance tenoxicam. Reduces the concentration of drug cardiac glycosides in blood.
Potentially nephrotoxic agents, antiplatelet agents, serotonin receptor antagonists and diuretics absolutely contraindicated.
Quinolone antibiotics increase seizure activity. The efficacy of mifepristone in the treatment of tenoxicam reduced.
Terms of sale
OTC Product.
Storage conditions
Temperature - 25 degrees.
Shelf life
2 years.
Cautions
It is recommended to control blood parameters.
Analogs Teksamena (substitutes)
Lornoxicam
Artrozan
Amelotex
Movalis
Meloxicam
Ksefokam
Revmoksikam
Structural alternatives: Tenikam . Tobit . Tenoktil .
Analogs Teksamena of pharmacological effects: Meloxicam . Movalis .
During pregnancy and lactation
Teratogenic in animal studies have been identified. There is no information about the negative effects of the active substance on the fetus. Tenoxicam penetrates into milk. The drug is contraindicated in Lactation .
Reviews Teksamene (Overview)
The injections are well tolerated without causing local reactions subject to the rules aseptic .
Doctors about Teksamene show a rapid action of the drug, which is very important in relieving pain . In general reviews about Teksamene positive and points to the high efficiency of the drug in the treatment of inflammatory diseases of the skeletal system.
Price Teksamena where to buy
In Russia, the price in Teksamena tablets It is 185 rubles.
The ampules are a bit cheaper. Price injections Teksamena - 140 rubles per 1 vial.
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