Description overdue on 09/21/2014
- Latin name: Orlistat
- ATC code: A08AB01
- Active substance: Orlistat (Orlistat)
- Manufacturer: Hayyan Farmasyut Syria Zhejiang Starry Pharmaceutical Co., Ltd., China
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Special conditions
- Side effects
- Instructions on Orlistat (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The active ingredient of the drug substance is the same name - Orlistat.
Product form
Orlistat is available in capsule, within which is contained a light-colored crystalline powder.
Pharmacological action
Tablets have inhibitory action gastrointestinal lipase .
Pharmacodynamics and pharmacokinetics
For this product is characterized by high lipophilicity and a good mix with fats. Also noted its active connection to the center pancreatic and Gastric lipase That leads to their inactivation. As a result, the penetration is blocked triglycerides in the blood. All this causes a shortage of energy, resulting in the mobilization of fat from the depot. Thus, Orlistat allows shorten quantity viscero-abdominal fat in the composition total mass. In addition, reduced hypercholesterolemia Reduced solubility cholesterol , Reduced tissue sensitivity to Insulin and falls hyperinsulinemia Contributing to the elimination of abdominal fat-viscero.
Thus orlistat substantially misses in the blood, and therefore does not exert systemic effects on the human body. Metabolism It occurs in the intestinal walls, resulting in formation of inactive metabolites . Because the body's substance excreted in the feces. The period of complete elimination is 5 days.
Indications
Orlistat - what is it?
Orlistat is a drug, is a specific inhibitor gastrointestinal lipases . The drug is actively used to reduce excess weight.
This drug is indicated for:
- of treatment obesity In order to reduce and maintain weight, combined with a diet;
- reduce the risk of re-raising after its decline.
Contraindications
Orlistat is not recommended at the reception:
- hypersensitivity;
- chronic malabsorption syndrome;
- cholestasis;
- the age of 12;
- nephrolithiasis;
- hyperoxaluria;
- lactation pregnancy.
Special conditions
This drug not recommended to the application of at children's age, when Lactation and pregnancy Because these patients safety and effectiveness is not fully established. It is not known what effect the substance has on the fetus, as well as whether its penetration into breast milk.
The use of orlistat is prohibited and pregnancy As well as lowering the weight during this period may cause harm to the pregnant woman and cause adverse effects on the fetus. Modern experts, of course, expectant mothers are advised to monitor the weight of the body, allowing the minimum raise, but not weight loss. This is true even of those women who are overweight or obesity.
Side effects
Admission of orlistat may be associated with adverse effects in the activities of the gastrointestinal tract: oily discharge from the rectum, flatulence, "bold" chair, frequent defecation, urgency to defecate, fecal incontinence.
Usually, the cause of side effects from the gastrointestinal tract becomes a high fat content in food. So to avoid this, you need to eat moderately hypocaloric food, which contains about 30% of the daily requirement of fat.
Besides, in the first 1-4 weeks of deviation can be observed in Nervous System , eg: headache, trouble sleeping, dizziness, anxiety .
Sometimes taking the drug causes intestinal steatorrhea due to malabsorption of fats and fat-soluble vitamin deficiency.
Instructions on Orlistat (method and dosage)
The medicament is intended for internal of reception. According to the instruction on the use of orlistat, a single dose is 120 mg, taken mostly used at each meal or an hour after but no more than 3 times a day. When the food contains a small amount of fat, it is allowed to pass reception capsules.
Overdose
Cases of overdose while taking orlistat are rare. They usually manifest disorders of the gastrointestinal tract. As a rule, systemic effects related to the drug lipazingibiruyuschimm properties quickly eliminated after its cancellation.
Cooperation
Simultaneous treatment with orlistat cyclosporine may reduce its concentration in plasma. So between these drugs is necessary to observe an interval of at least 2-3ch.
Also found that Orlistat reduces the absorption of beta-carotene Which is a part of nutritional supplements. It is noted, and its effect on the absorption of Vitamin E .
Sometimes a combination of Orlistat levothyroxine sodium causes the development of hypothyroidism . Such cases require a monitoring of thyroid function, so you need to respect the interval between taking the drug at least 4h.
Terms of sale
Capsules Orlistat is possible to buy without a prescription.
Storage conditions
To store the drugs designed dark and cool place, protected from the children.
Shelf life
2 years
Analogs of Orlistat
Ksenalten
Orsoten
Xenical
Modern pharmacology offers a multitude of preparations intended for struggle against excess weight. At the same time analogues of orlistat presented by means of: Allicor, Ksenalten, Xenical, Listata, Orlimaks, Orsoten and others.
Alcohol
It was found that alcohol does not have much effect on the pharmacokinetics or pharmacodynamics of the drug.
Comments about Orlistat
As evidenced by the numerous reviews of orlistat in the forums, the problem of excess weight bothers many people. This is especially true for women after childbirth. They begin to try a variety of diet and drugs on their own, but this approach is seldom effective.
If the ladies are turning to specialists, they perform competent selection of a diet with the possible use of special medicines. At the same time reviews of orlistat doctors indicate that the drug helps to reduce weight quickly and keep the resulting shape. It is also possible to the appointment of its main analogue of, of the drug Xenical . Of course, process of losing weight requires serious approach with a change in lifestyle, the choice of diet, of regular physical loads and so on.
It should be noted that ratings of slimming women, advantageously positive . They report that taking this remedy, could lose half a year at least 10 kg. After this the weight of starts to leave not so quickly, but all the same stably is lowered.
However, not everyone is happy with the action of orlistat. Some women say that the appointment of the drug did not bring them any result, development has caused more side effects associated with the activity of the gastrointestinal tract. Typically, these messages leave the ladies with a weight of over 100 kg. However, they write that excluded from the diet of flour and sweet, and the other features of power and life is not describe.
As is known, superfluous kgs accumulate over the years and quickly get rid of them absolutely uneasy. The process of Slimming requires an integrated approach throughout long time. It is desirable to fight obesity under control specialist, as this allows you to select the right program and get a guaranteed result.
Price orlistat, where to buy
Capsules 120mg of 20 pieces can be purchased in Moscow within 1400-1500 rubles.
Price Orlistat in Ukraine amounts to 237, 96 UAH.
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