Cefuroxime

Description overdue on 16.03.2012

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Cephalosporin antibiotic . The mechanism of action of the antibacterial agent directed to violation of the flow of the normal process of synthesizing the microbial wall. The drug is used parenterally, orally. Cefuroxime has bactericidal action. The drug acts on a wide range of bacterial cells. The medicament is discharged in the form of granules, solution, powder and pellet form.

Indications:

Cefuroxime prescribed for bacterial infections. Respiratory system : empyema , Abstsess lungs, pneumonia, bronchitis. Urinary system: gonorrhea . asymptomatic bacteriuria . chronic pyelonephritis . ENT organs:   otitis, tonsillitis, sinusitis, pharyngitis . Skin and soft tissue:   erysipeloid, wound infection, abscess, abrasions, impetigo Pyoderma, erysipelas.   Skeletal system: septic arthritis , Osteomyelitis. Antibacterial drug is effective in Lyme disease , Meningitis, sepsis, adnexitis, endometritis , Borreliosis. Cefuroxime prescribed drug for the prevention of postoperative complications.

Contraindications:

Cefuroxime is not indicated in case of intolerance carbapenem, penicillin and cephalosporin antibiotics. The drug is contraindicated in bleeding in the digestive system, pregnancy, exhaustion, nonspecific ulcerative colitis , Breastfeeding, with weakened immunity.

Side effects and overdose:

Local reaction:   phlebitis, infiltration at the injection site irritation. Allergic reactions: bronchospasm May develop erythema multiforme, rarely develops an anaphylactic shock. Urogenital:   vaginitis, itching perineum passing. The digestive tract:   spasms and epigastric pain, vomiting, nausea, diarrhea . candidiasis   oral ulceration oral pseudomembranous enterocolitis . Possible hearing loss hemolytic anemia , Seizures, hyperbilirubinemia . In overdose recorded seizures, stimulation of the nervous system. Timely receiving antiepileptics, peritoneal dialysis, maintaining body functions, hemodialysis.

Mode of application:

Cefuroxime is administered intramuscularly, intravenously, taken orally. Injection antibiotic: three times a day at 750 mg, and in severe cases, the dose was increased to 1500 accept triplicate. The optimal dose for most infections: 60 mg / kg / day. Treatment of gonorrhea: 1500 mg intramuscularly once a dose is divided into 2 injections. Bacterial meningitis: every 8 hours intravenously for 3 grams of antibiotic. When surgical interventions: 1500 mg intravenously, then intramuscularly three times a day 750 mg two days. When pneumonia intravenously or intramuscularly, 2-3 times per day, 1500 mg, treatment for 2-3 days, then transferred to oral forms, twice daily, 500 mg, treatment of 7-10 days. Treatment AECB intravenously, intramuscularly and 750 mg twice a day for 2-3 days.

Special instructions:

For patients allergic to penicillin may develop an allergic response to the cephalosporin antibiotics. Antibiotic therapy requires control over the functioning of the renal system (blood chemistry). During the period of drug administration offers the possibility of false positive reactions Coombs. The prepared solution was stored no longer than 7 hours at room temperature when stored in the refrigerator -dvoe days. Slightly yellowed antibiotic solution is considered suitable for use.

Drug Interactions:

Tubular secretion slows down while taking oral forms of "loop" diuretics, also notes an increased concentration of the antibiotic in the blood and reduced renal clearance. The risk of developing nephrotic effects increases with simultaneous use aminoglycosides . Cefuroxime is incompatible with dextrose, sodium chloride, lidocaine, Ringer , Heparin sodium Hartman.