Description overdue on 12/11/2014
- Latin name: Polyoxidonium
- ATC code: L03
- Active substance: Azoksimera bromide (Azoximer bromide)
- Manufacturer: NGOs Petrovax Farm Ltd., Russian Federation
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on polioksidony
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Polioksidony children
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The composition of one pills Polioksidoniya comprises 12 mg of active ingredient and potato starch (Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum) as accessory components.
In one vial with lyophilisate It contains 6 mg of active ingredient, and mannitol (E421; Mannit), povidone (Povidonum) and beta-carotene (Betacarotenum) as accessory components.
To produce one rectal-vaginal suppository 6 is used, or 12 mg of active ingredient and auxiliary ingredients: mannitol (E421; Mannit), povidone (Povidonum), beta-carotene (Betacarotenum), cocoa butter (Butyrum Cacao).
Product form
Polioksidony has three dosage forms:
- pills;
- rectal-vaginal suppositories;
- Dried powder .
Suppositories are shaped torpedo colored in light yellow color and specific smell cocoa butter.
Valium tablets, each of which has a bevel. Their color can vary from off-white to orange-yellow. In tablets, the notable exception of a little more intense color of the particles.
Pharmacological action
Polioksidony belongs to a group of funds that have immunocorrecting and detoxification effect .
Pharmacodynamics and pharmacokinetics
Polioksidony (or azoksimera bromide ) promotes increase body resistance against induced viruses . bacteria or fungal infections .
Its mechanism of action is associated with the ability to influence the substance phagocytic cells and NK cells (natural or natural killer cells) and stimulate the formation of antibodies .
The drug helps building the immune status with secondary immunodeficiency states Which are due to various types of infection , Trauma, burns . malignancy , Complications after surgery, treatment with chemotherapeutic drugs, including, without limitation cytostatic agents and steroidal hormones .
Along with immunocorrecting action azoksimera bromide It has also expressed detoxifying action That due to the structure and nature of the high-molecular substance.
As a result of its impact on the body is to increase stability cell membrane to cytotoxic (causing cell damage until their death) effects of drugs and chemicals, as well as reducing the toxicity of the latter.
Purpose polioksidoniya in combination with other drugs for the procedure increases the efficiency of treatment and reduces its duration, thus reducing the dose or avoiding the application does antibiotics . bronchodilator and glucocorticosteroid funds It helps to increase the period of remission (i.e., periods of weakening or complete disappearance of symptoms).
Polioksidony well tolerated, does not show polyclonal or mitogenic activity , Does not possess antigenic properties Without provoking development allergies . mutations and other defects of the fetus , Does not possess teratogenic on the developing fetus does not have carcinogenic and embryotoxic properties .
Azoksimera bromide harakterzuetsya high refractive bioavailability that is about 89 percent. Intramuscular injection of the drug Cmax in the plasma It observed 40 minutes after injection.
Substance rather quickly distributed in the tissues. In the body, azoksimera bromide biotransformiroetsa. Its elimination is carried out mainly kidney .
Indications
Indications tablets
Adult patients and adolescents over 12 years polioksidony tablets prescribed, usually used as an adjunct to therapy.
The medicine is indicated for acute and chronic relapsing inflammatory and infectious diseases of the oral cavity . paranasal sinuses . upper respiratory tract , In inner and middle ear .
Immunocompromised patients (patients with secondary immune deficiency ) Polioksidony taken sublingually administered as monotherapy for prophylaxis Flu and other acute respiratory infections in the period prior to seasonal epidemics.
Indications lyophilisate
The solution, which is prepared from a lyophilized powder, for administration in muscle or vein And for outdoor applications.
Adult patients it is prescribed as an adjunct to primary therapy for:
- resistant to standard therapy inflammatory diseases of various origins during the period of exacerbation and remission (including the chronic and recurrent disease );
- rheumatoid arthritis (if the patient was treated for a long period immunosuppressive drugs );
- complicated by acute respiratory infections or ARI, rheumatoid arthritis ;
- occurring in acute or chronic infectious diseases Provoked by activity Virus or bacteria (including diseases of the urogenital tract);
- tuberculosis ;
- diseases of allergic nature Which are complicated by chronic recurrent bacterial or viral infections ;
- conditions originating in the background radiotherapy or chemotherapy of malignant tumors .
As a supplement to the basic therapy polioksidony apply in cases where the need to reduce hepato- and nephrotoxic effects of drugs . Because the drug stimulates tissue regeneration , It is expedient to use for the treatment burns . bone fracture and trophic ulcers .
Monotherapy with jabs Polyoxidonium shows:
- to prevent the development of infection in the postoperative period;
- correction secondary immunodeficiency Which are a consequence of aging, or adverse effects of external factors;
- prophylactically for the prevention of influenza and acute respiratory disease .
Babies polioksidony in the form of a solution is permitted to apply to six months. The drug is prescribed as an adjunct to primary therapy:
- at infectious and inflammatory diseases (including but not limited ENT disease - adenoid vegetations . SARS . inflammation of the pharyngeal tonsil . nasal or paranasal sinuses etc.);
- at acute allergic reactions and toxic-allergic lesions ;
- when proceeding with complications asthma ;
- in complicated purulent infection of atopic dermatitis ;
- for conditions involving disruption of the normal intestinal bacterial composition ;
- for the rehabilitation of children with FIC syndrome ;
- prophylactically for the prevention of influenza and acute respiratory disease .
Indications for use of suppositories
Indications for the drug in the form of suppositories for rectal and vaginal administration are the same as for the solution. The use of suppositories is useful when inflammatory diseases of different localization and different etiologies . arthritis For the treatment of tumors For preventing Infectious Diseases children and the elderly.
Candles polioksidony often prescribed for the treatment of female diseases . Candles in gynecology prescribed for cervical erosion . endometritis . leukoplakia . coleitis . salpingitis . dysplasia etc..
Contraindications
The drug is contraindicated for people with individual intolerance to the components.
Side effects
Side effects of the tablets and suppositories are reaction hypersensitivity . Intramuscular injection of the drug in some patients may experience redness and soreness at the injection site. After the first shots Polyoxidonium can raise body temperature.
Instructions on polioksidony
The dose and route of administration will determine, depending on the diagnosis, the characteristics of the disease and age of the patient.
Instructions on pills Polyoxidonium
Tablets intended for sublingual (under the tongue) or oral (oral) administration. They drink daily, one, two or three times a day (the multiplicity of methods depends on the nature of the disease and the severity of the clinical picture) for 20-30 minutes before eating.
A single dose of the drug for adults - 1 or 2 tablets (equivalent to 12 and, respectively, 24 mg azoksimera bromide), adolescents prescribed to take 1 tablet for the reception.
Instructions for use in the form of freeze-dried product Polyoxidonium
The solution is administered intramuscularly or droplets into the vein applied intranasally.
For treatment inflammatory diseases in an acute form preparation is administered daily for 3 days at a dose of 6 mg. Further injections Polyoxidonium continue to do through the day. Typically, the patient takes between five and ten injection.
For treatment inflammatory diseases and chronic rheumatoid arthritis 5 first injections are made in a day, still more drug administered two times per week. A single dose of the active substance of 6 mg. Full course involves no fewer than ten injections.
Patients who have been diagnosed tuberculosis Appoint administered 6 mg 2 times a week. Full course - from ten to twenty injections.
Patients with diseases of the urogenital tract recommended that a ten injections (every other day). Single dose - 6 mg. Complementary therapy appointment chemotherapy drugs .
A similar scheme is also treated patients chronic recurrent herpes . Thus polioksidony administered in combination with stimulants synthesis of endogenous interferon . antiviral agents . interferon preparations .
Therapy place in the complicated form allergic diseases It involves administering five single doses of the drug (6 mg). The first two injections recommended daily remaining three injections made in a day.
At allergies and toxic-allergic lesions shown intravenous dose of 6-12 mg, in combination with drugs possessing anti-allergic action (including clemastine ).
Patients who are receiving Chemotherapy (and after it) to reduce the specific action chemotherapeutics the drug is prescribed in a dose of 6-12 mg. The optimal holding not less than ten injection (maintaining the daily interval between them).
To correction of immunodeficiency after radiation and chemotherapy After removal of the tumor by surgery to a patient 1-2 times per week is administered a dose of 6 mg. The course of treatment sufficiently long - typically from 2-3 to 12 months.
According to the instructions for use in patients with injections Polyoxidonium acute renal failure inject the drug is allowed no more than 2 times a week.
To prepare a solution for intramuscular injection of 6 mg of active substance (content of one ampoule or a vial) is coupled to 1, 5-2 ml of NaCl solution or water for injection.
A solution to drip into the vein is prepared by mixing the contents of an ampoule or vial with 3 ml of NaCl, gemodeza , Plasma-drug reopoliglyukina or 5% glucose solution. The resulting solution should be aseptically transferred to a vial with some of the volume of said solutions 0, 2-0, 4 liters.
Solution for parenteral administration must be used immediately after preparation, storage, it is not subject.
Intranasal application is shown in the acute and chronic infectious diseases of ENT To accelerate the regeneration of the mucous membranes For the prevention of complications and recurrence of disease prevention Influenza and respiratory diseases .
To prepare the solution of 6 mg nasal liofizata combined with one milliliter (20th drops) of distilled water, NaCl solution or a conventional boiling water. The temperature of the liquid should be room temperature.
The solution is not less than 3-4 times a day administered in each nostril, keeping between instillation of 2-3 hours. A single dose of - 1 to 3 drops in each nostril. Treatment continued for five to ten days.
After dilution of the drug remains stable throughout the day, and then you can not use it.
Candles polioksidony: instructions for use
Candles 12 mg and 6 mg administered rectally after the procedure cleansing bowel Once a day (before bedtime). Single dose - one suppository. Scheme of administration is as follows: one day during the first 3 days, then - the same one - 2 days. For a full course takes 10 suppositories.
Intravaginal use for shows treatment of gynecological diseases : dysplasia . erosion . lekoplakii cervix . colpitis . adneksita . endometritis And diseases triggered human papillomavirus (HPV).
Treatment involves daily administration for three days, one suppository a dosage of 12 mg of the active substance, after which a candle continue to enter through the day. The course is carried out using 10 suppositories. Where appropriate, a course of treatment are allowed to repeat after 3-4 months.
Patients diagnosed with Chronic immune deficiency (including inter alia the patients was a consequence of this state cancer ) Polioksidony assigned as the support means at a dose of 6 mg or 12 (by the physician), 1-2 times a week. Treatment long.
Overdose
Data on overdose polioksidonija in the form of tablets and suppositories do not. When applying the solution in therapeutic doses prescribed overdose also were not detected. Potential side effects may be increased.
If signs of overdose symptomatic therapy is recommended.
Cooperation
Polyoxidonium allowed to use in combination with antibiotics . antiviral and antihistaminics . antimycotics ; cytostatic . glucocorticosteroid and bronchodilator drugs . β-adrenostimulyatorov .
If necessary, the method of adding the solution dropwise into a vein should not dilute it infusion solutions, which are present in the composition of proteins.
Terms of sale
Tablets and suppositories are classified as non-prescription drugs, to acquire lifilizata require a prescription.
Storage conditions
The tablets were stored at a temperature not exceeding 25 ° C. Keep away from children
Suppositories are listed B. Keep them recommended in a dry, dark place. Keep away from children. Optimal temperature control - from 2 ° to 15 ° C.
The lyophilisate should be stored in a dry, dark place. The optimum temperature range - from 4 to 8 ° C. Keep away from children.
Shelf life
2 years.
Analogs Polyoxidonium
Derinat
Interferon
Neovir
Treatment with artrofoon
Nazoferon
Timalin
Viferon
Timogen
Roncoleukin
TSikloferon
Broncho-Vaks
Infagel
Uro-Vaks
IFN-EU-Lipint
IFN-EU
IFN-Lipint
Altevir
Algeron
Laferobion
Analogs drug mechanism of action: Aktinolizatom . Anaferon . Arpetolid . Arpeflyu . Affinoleukine . Bestin . Bioaron . Broncho-Vaks . Vilozen . Gepon . Gerbion . Glutaksim . Isophorone . Immunal . Immunofan . Neyroferon . Ribomunil . Taktivin . Florex . TSikloferon . Tsitovir 3 . Engistol . Polimuramil . Ismigen .
Polioksidony children
In pediatric practice, the use of tablets allowed 12 years, suppositories are used to six years of age, the lyophilizate is used to six months.
Babies polioksidony prescribed as an adjunct to primary therapy. Indications for use are the acute and chronic infectious and inflammatory diseases (including but not limited SARS and ENT disease ) allergy and toxic and allergic conditions , Complications of chronic infection in the respiratory tract, bronchial asthma Flowing with complications (including complicated by purulent infection) atopic dermatitis, goiter .
Children included in the group of "FIC" the drug is used to accelerate the process of their rehabilitation. In addition, polioksidony has a preventive effect against colds and flu .
The tablets are administered orally or sublingually in a dose of 12 mg (one tablet) daily, with a multiplicity of applications 1, 2 or 3 times a day.
The optimum dosage and frequency of injection amount is determined depending on the diagnosis and the age of the child:
- In acute proceeding inflammatory diseases It is shown holding a day for five to seven injections. Dose - 100 mg / kg. If a chronic disease, the dose was increased to 150 mg / kg. Imposition of a drug through the day. The course involves the introduction of up to ten individual doses.
- To treatment of allergies and toxic-allergic states It shows a drip drug into the vein at a dose of 150 mg / kg. Complementary therapy appointment clemastine and other drugs that provide anti-allergic effect. If the disease occurs with complications, injections administered as a supplement to the basic treatment. 5 patients showed holding intramuscular injections at a dose of 100 mg / kg. The interval between injections - 1-2 days.
Solution for intramuscular administration is prepared by dissolving 3 mg in 1 ml NaCl solution (may be water for injection).
Solution for intravenous administration is prepared by diluting 3 mg in 1, 5-2 ml NaCl, 5% glucose solution, or poliglyukina gemodeza then aseptically added to the vial with a volume of said solutions of 0, 15-0, 25 l.
Polioksidony applied intranasally daily for five to ten days, burying it at least 3-4 times per day in each nostril at a dose of from 1 to 3 drops. The daily dose - 150 mg / kg body weight. The interval between treatments - 2-3 hours.
To prepare a solution for topical application to 3 mg, 1 ml (equivalent to 20 drops) of liquid at room temperature (0.9% NaCl solution, distilled water or normal boiled).
Babies solution was administered at a dose of 150 micrograms of active substance per kilogram body weight (the amount thereof is contained in one drop of solution).
The sublingual drug is prescribed to be taken daily for 10 days. The daily dosage for all indications - 150 mg / kg. If the drug is used for treatment of dysbacteriosis course lasts typically 10 to 20 days.
The solution was stored in the refrigerator for more than one week. Before instillation of the drug pipette solution should be warmed to room temperature.
According to the instructions on the candle for the children, the drug in the dosage form is allowed to be administered rectally to treat patients older than 6 years.
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