Izoprinozin

Description overdue on 18/09/2014

• Latin name: Isoprinosine
• ATC code: J05AX05
• Active substance: Pranobex Inosine (Inosine Pranobex)
• Manufacturer: TEVA Pharmaceutical Works Private, Ltd. Co. (Hungary)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications tablets Isoprinosine
• Contraindications
• Side effects
• Instructions for use izoprinozin (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The structure of 1 tablet of 500 mg Isoprinosine included inosine pranobex (izoprinozin)   - Active substance.

Additionally, the tablet contains:

• 10 mg - povidone;
• 67 mg - wheat starch;
• 67 mg - mannitol;
• 6 mg - magnesium stearate.

Product form

Isoprinosine medicament is manufactured in the form of biconvex tablets oblong white or close to the color on the one side with the mark.

One package contains 20, 30 or 50 tablets.

Pharmacological action

Immunostimulant, antiviral.

Pharmacodynamics and pharmacokinetics

Izoprinozin is complex derivatives purine synthetic origin   and exhibits immunostimulatory effects, and also has non-specific antiviral effects.

Application izoprinozin leads to recovery lymphocyte function   during immunosuppression Increases blastogenesis among monocytic cells, activates the expression of membrane receptors on the surface of T-helper cells, prevents lowering activity lymphocyte cells when exposed to glucocorticoids, normalizes them interpolation thymidine.

Inosine pranobex   It stimulates the activity of natural killer cells and cytotoxic T lymphocytes, activates the function of T-helper and T-suppressor, increases production immunoglobulin G, interleukins IL-1 and IL-2, interferon-gamma, reduces production of proinflammatory cytokines - IL-4 and IL-10 enhances the chemotaxis   macrophages monocytes   and neutrophils.

Isoprinosine has in vivo antiviral activity against viruses Herpes simplex (cold sores) . measles virus . Cytomegalovirus , Influenza A and B virus T-cell lymphoma type III enterotsitopatogennomu human viruses, polioviruses and equine encephalitis   and Encephalomyocarditis .

Antiviral drug effects associated with inhibition of RNA and digidropteroatsintetazy enzyme which is involved in the synthesis of certain viruses. Also, the drug stimulates the previously suppressed virus replication mRNA lymphocytes, in connection with what is happening inhibition of the biosynthesis of RNA of the virus and reducing the biosynthesis of viral proteins .   increases the production of interferons alpha and -gamma That exhibit antiviral activity.

The combined application increases efficiency   interferon alpha And antivirals Zidovudine   and Acyclovir.

Following oral administration are well and fairly rapidly absorbed from the gastrointestinal tract.

Cmax in plasma already after 1-2 hours.

Undergoes rapid metabolism to form uric acid excreted in the urine.

Cumulation of the drug in the body was found.

The half-life for the two metabolites is 3, 5 hours and 50 minutes.

Complete elimination of the drug from the body of the patient Isoprinosine takes 24-48 hours.

Indications tablets Isoprinosine

• therapy virus influenza and other SARS;
• infectious diseases, which were caused by herpes virus 1, 2, 3, 4 and 5 type (lately appeared information about the effectiveness of the treatment of herpes type 6 and type 7, and 8) labial herpes, genital herpes   and herpetic keratitis;
• chickenpox, shingles;
• kissing disease Due to herpes virus type 4   (Epstein-Barr virus);
• measles   (in severe disease);
• cytomegalovirus infection Caused by herpes virus type 5;
• molluscum contagiosum;
• human papillomavirus (HPV) Including papilloma vocal cords and larynx, the fibrous type;
• Also, the drug is effective in HPV genital women and men in therapy for getting rid of warts.

Contraindications

• gout;
• arrhythmia;
• urolithiasis disease;
• chronic renal failure;
• contraindication to receiving izoprinozin include children up to 3 years old with a body weight up to 20 kg, and increased sensitivity to the components of the drug.

Side effects

According to the WHO side effects izoprinozin classified into "parts" to display frequency of 1% to 10% "sometimes" displays a frequency of 0 1% to 1%. Also, the side effects of the drug are divided into groups according to their effect on the various organs and systems of the human body.

Bodies of the digestive tract:

• often - pain in the epigastric region, nausea, vomiting.
• sometimes - constipation   or diarrhea.

Liver and biliary ways:

• frequently - an increase in plasma activity alkaline phosphatase   and transaminases   as well as the increase of urea .

Skin and subcutaneous adipose tissue:

• often - itching.

Nervous system:

• often - headache . weakness . feeling dizzy.
• sometimes - sleep disorders ( drowsiness   or insomnia ).

Urogenital:

• sometimes - polyuria.

Musculoskeletal system:

• often - worsening of gout , Pain in the joints.

Instructions for use izoprinozin (method and dosage)

Instructions on Isoprinosine recommends taking pills orally (inside) after meals with water.

Generally, a daily dose for adult patients Isoprinosine and patients from 3 years old, weighing 20 kg, 50 mg / kg, 3-4 times daily.

Adult patients prescribed 6-8 tablets a day for children - half a tablet for every 5 kg of body weight per day.

If necessary, in severe cases of infectious diseases, the daily dose can be individually increased to 100 mg / kg body weight in 4-6 doses.

For patients aged adult maximum dose per day is 3-4 grams.

Instructions for use of children determines the maximum daily dose for this age group was 50 mg / kg.

In the treatment of acute diseases treatment for all ages going on for 5 - 14 days. After the disappearance of symptoms pills continue for 2 more days. If necessary and for the supervision of a physician, therapy can be increased.

In chronic relapsing pathologies prescribed several courses of treatment lasting 5-10 days, with an interval of eight days between courses.

Supportive therapy may extend from the reception low daily dose of 500 mg or 1000 mg of (1-2 tablets). The course of treatment is carried out for 30 days.

Herpetic infection   required treatment for 5-10 days until complete disappearance of symptoms, and continues in an asymptomatic period for a further 30 days at a daily dose of 1000 mg broken into 2 doses (to reduce the risk of potential recurrence).

At HPV recommended daily dose for adult patients of age 6 tablets (2 tablets. three times a day), and sex tablet per 5 kg for pediatric patients, in 3-4 divided doses. Monotherapy continued for 14-28 days.

At genital warts   with recurrent drug administered in the same doses as in the HPV . Treatment may be carried out as monotherapy, or in combination with surgical treatment for 14-28 days. Subsequent study showed a threefold repetition of therapy with intervals of 1 month.

At cervical dysplasia,   due to the impact of HPV , A daily dosage of 6 tablets in 3 doses (2 tablets). The course of treatment is 10 days, followed by 2-3 similar courses, with an interval of 10-14 days.

The cost of a course of therapy with izoprinozin require significant funds, so take a look before the treatment, as are tablets of the drug that would in the future not to interrupt the process of therapy.

Overdose

Drug overdose cases Isoprinosine not described.

Cooperation

Uricosuric drugs   (including diuretics ), and xanthine oxidase inhibitors   increase the risk of increase in the serum concentration Uric acid , For the treatment of izoprinozin.

Immunosuppressive   reduce the effectiveness of izoprinozin.

Terms of sale

Prescription.

Storage conditions

Store at a temperature not higher than +25 ° C.

Shelf life

5 years.

Cautions

After 2 weeks of treatment with izoprinozin need to conduct research on the content Uric acid   in urine and serum.

During the long-term treatment (more than 4 weeks) is recommended every month to monitor renal and hepatic function (activity transaminases Level creatinine Contents Uric acid ).

It is necessary to monitor the level of Uric acid   Blood izoprinozin when applied in combination with drugs that increase its level, as well as drugs disrupt the function of the kidneys.

Analogs izoprinozin

Match code ATC 4th level:

• Kagocel
• Allokin Alpha
• Panavir
• Ingavirin
• Groprinosin
• Amizon
• Anaferon
• Arbidol

Due to the relatively high cost of the drug often seek its analogs less expensive than drug Isoprinosine.

It is worth noting that the price of analogues izoprinozin can actually be much lower, but often they do not have so much pronounced immunostimulatory and antiviral effects.

Searching for products with the same action you can offer the following medicines:

• Allokin Alpha;
• Amiksin;
• Amizon;
• Arbidol;
• Lavomax;
• Panavir;
• Kagocel;
• Proteflazid   etc.

Synonyms

The main izoprinozin is synonymous with drug Groprinosin,   which includes the same active ingredient.

If there are problems with immune and above indications doctor may prescribe Groprinosin   or Isoprinosine. What is the best of these drugs to take in a particular case can be solved only by an expert immunologist.

It may be noted more sparing dosing regimen of the drug Groprinosin In this connection, it is more commonly prescribed for the treatment of children and the elderly.

Babies

Izoprinozin for children is appointed solely for the doses that are prescribed for children instruction manual.

Prevention of viral diseases izoprinozin often receives positive feedback for children from 3 years.

With alcohol

During the prevention and treatment of viral diseases is not necessary to combine Isoprinosine and alcohol.

Alcohol intake, especially in large quantities, detrimental effect on the human immune system, therefore compatibility with alcohol preparations enhance immunity In the best case result in a mutually leveling effects.

During pregnancy and lactation

Security izoprinozin use during pregnancy and lactation has not been investigated.

Reviews izoprinozin

Positive and negative feedback on the use of the drug Isoprinosine adult patients for the prevention and treatment SARS and influenza   divided about equally, although even with a negative attitude to this drug is rare to find mention of side effects. More often talk about   placebo effect Which supposedly replaces izoprinozin action itself, which is quite controversial.

Among the positive responses: decrease the duration of disease states more than doubled, rapid relief of symptoms, lower incidence of subsequent infection, the virtual absence of negative effects.

Reviews izoprinozin at HPV As in the warts   and Herpes Also did not come to a common denominator. Note that the treatment HPV   and Herpes   Best results shows combination therapy.

Babies often prescribed Isoprinosine to prevent seasonal SARS and influenza Wherein the medicament shows the best results. In this regard, children izoprinozin reviews, mostly positive.

Izoprinozin - an antibiotic or not?

Recall that the drugs belonging to the group antibiotics,   used for the treatment of diseases caused by pathogenic organisms (bacteria) Whereas Isoprinosine refers to drugs that affect immune system   and possessing antiviral activity.

Price izoprinozin where to buy

Buy Isoprinosine in Moscow, you can approximately:

• pack of 20 tablets - 500 rubles;
• Packaging 30 tablets - 800 rubles;
• Packaging 50 tablets - 1300 rubles.

On average, the price of 10 tablets will be izoprinozin - 250 rubles.

Price izoprinozin in Ukraine is approximately (500 mg tablets 50 pieces) - 450 hryvnia.

Get the best price and buy