Description overdue on 03/09/2014
- Latin name: Hepa-Merz
- ATC code: A05BA
- Active substance: Ornithine (Ornithine)
- Manufacturer: Merz Pharma GmbH & Co. KGaA (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Gepamertsa
- Contraindications
- Side effects
- Hepa-Merz, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One sachet contains a mixture of 5 g of granules for solution Hepa-Merz, a part of which contains 3 g ornithine aspartate (active drug), and the following excipients: E110 (dye orange yellow), orange and lemon flavor, sodium cyclamate, levulose, saccharin and polyvinylpyrrolidone.
As part of one vial of concentrate for solution Hepa-Merz, the present 5 ornithine aspartate, and 10 ml. water for injection (secondary connection).
Product form
The granulate (a mixture of pellets Hepa-Merz, white and orange) for solution packaged in sachets of 5 g each. One carton contains 30 sachets.
Concentrate producing ampoules made of dark glass, a nominal volume of 10 ml. One carton contains 10 vials.
Pharmacological action
The drug has on the human body hepatoprotective pharmacological effects. Hepa-Merz treat hypoazotemic pharmaco-therapeutic group of drugs.
Pharmacodynamics and pharmacokinetics
Actively active compound ornithine aspartate Contained in the composition Hepa-Merz participates in biosynthesis from Ammonia Urea (ornithine Krebs cycle) And promotes the development of STG and insulin Accelerates proteometabolism It improves liver function ( detoxification effects ) And reduces ammonia in blood.
The drug substance is rapidly absorbed in the stomach and enters the bloodstream through the intestinal epithelium and excreted in the urine.
Indications Gepamertsa
Indications for use Hepa-Merz are:
- liver disease , Including chronic or acute, accompanied ammoniemia ;
- hepatic encephalopathy .
In the combined therapy drug used to treat disturbances of consciousness ( coma or state precoma ). In addition, Hepa-Merz serves as corrective additives in the treatment of patients with diet protein deficiency .
The drug can be used to remove intoxication at Alcohol Poisoning .
Contraindications
The drug is contraindicated in impaired renal function (at a content in the blood of 3 mg / 100 ml. Creatine ).
Side effects
It is worth noting that these possible side effects of the drug as a nausea, allergic rashes on the skin and vomiting It occurs rarely.
Hepa-Merz, instructions for use (method and dosage)
In accordance with the instructions for use Gepamertsa medication is recommended to take after a meal. To prepare a single dose of the drug should be mixed with 200 ml. Water (preferably room temperature) with a sachet containing 5 g of granulate powder .
Hepa-Merz solution infusion is administered intravenously at a dose equal to '20 (i.e., four vials of drug) per day. The recommended average daily therapeutic dose of drug may be increased to a maximum of 8 vials ('40) per day.
Hepa-Merz drug is not produced in the form of tablets.
Overdose
Increased side effects of the drug may signal overdose Hepa-Merz. In this situation the first stop use of this drug. Patients washed stomach, symptomatic treatment and prescribe Activated carbon .
Cooperation
There is currently no information on drug interactions Hepa-Merz with other drugs.
Terms of sale
Without prescription from pharmacies.
Storage conditions
Keep out of the reach of children, at a temperature not exceeding 25 ° C.
Shelf life
5 years.
Cautions
Before direct intravenous solution Hepa-Merz should not dissolve more than 6 vials (500 ml. Of solution for infusion) drug at a time. In order to avoid vomiting and nausea to optimize the speed of drug administration.
During use of the drug for the treatment of hepatic encephalopathy Patients are advised to refrain from driving and not to work with potentially dangerous machinery or engage in activities requiring high concentration, and besides quick mental response.
Hepa-Merz Analogs
Enerliv
Laennek
Progepar
Antral
Potassium Orotate
Glutargin
Legalon
Phosphogliv
Galstena
Karsil
Essentiale
Structural analogues of Hepa-Merz and considered Ornitsetil , and Ornithine .
Synonyms
Hepa-Merz.
During pregnancy and lactation
Although pregnancy and does not relate to an absolute contraindication to the use of Hepa-Merz, to take the drug during this period should be only under medical supervision. While receiving the drug is recommended to stop breast-feeding .
Reviews of Hepa-Merz
People who took the drug, left the bulk of positive feedback on the forums on the medicinal product, noting its effectiveness and the small number of contraindications and side effects. Judging by the reviews of the Hepa-Merz, this drug fits a wide range of patients, including children and the elderly.
Price Hepa-Merz, where to buy
Gepamertsa Cost varies by region and release form of the drug. In pharmacies, the drug can be bought without a prescription.
Average price Gepamertsa ampoules (in multiples of 10 pcs. 10 ml. each) is 3000 rubles.
Packing granulates (10 sachets 5 mg. Each) will cost about 650-700 rubles.
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