Description overdue on 08/12/2014
- Latin name: Folacin
- ATC code: B03BB01
- Active substance: Folate (Folic acid)
- Manufacturer: Jadran Galenski Laboratorij (Croatia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Folacin
- Contraindications
- Side effects
- Instructions on Folacin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The tablet contains: active substance - folic acid - 5 mg, auxiliary components: lactose monohydrate . cellulose microcrystalline Povidone . crospovidone and magnesium stearate .
Product form
Folacin is available in tablets of 5 mg active material packed at 10, 20 or 30 pieces.
Pharmacological action
The drug has hematopoietic effect.
Pharmacodynamics and pharmacokinetics
Folacin refers to vitamin B. Once in the body, it is converted to tetrahydrofolic acid As a coenzyme involved in important metabolic processes and necessary for the full maturation megaloblasts and education normoblasts. Deficiency folic acid It leads to the development of type megaloblastic hematopoiesis. Average flow of matter in the human body helps to stimulate erythropoiesis It improves synthesis amino acids , eg, methionine, serine, glycine, nucleic acids, purine and so on.
During pregnancy folic acid It protects the fetus from teratogenic and damaging factors. And also favors the normal maturation and activity of the placenta.
After Ingestion absorption folic acid It occurs in the gastrointestinal tract, almost immediately binding to plasma proteins. Then the material is deposited in the liver and it is formed of tetrahydrofolic acid.
This component crosses the placenta, BBB, and gets into breast milk. Maximum concentration in the blood reached within 30-60 min. Withdrawal occurs in unmodified form or as metabolites via the kidneys, about 5 hours later.
Indications Folacin
The main indications for use folacin are:
- treatment and prevention of folate deficiency caused by unbalanced or malnutrition;
- treatment and prevention of various types of anemias amid lack of body folic acid For example, in the development of disease and complications Lactation and pregnancy and so on.
In addition, the drug is prescribed to pregnant women for the prevention of neural tube abnormalities in the fetus.
Contraindications
- intolerance of components;
- malignancies;
- pernicious anemia;
- cobalamin deficiency.
Side effects
In the treatment of folacin and other drugs folic acid may develop allergic reactions as: itching . skin rash . erythema and bronchospasm .
Also, do not rule out abnormalities in the activity of the gastrointestinal tract, such as: anorexia . nausea . bitter taste in the mouth . abdominal distention and other.
Instructions on Folacin (method and dosage)
The drug is intended for oral administration. According to the instructions for use folacin, during the treatment or prevention of folic acid deficiency, various dosages.
For example, in the treatment of anemia, megaloblastic prescribe a daily dose of 5 mg, and for the prevention of this condition - 2, 5 mg.
For the prevention of fetal neural tube defects is recommended to take 2, 5 mg for 4 weeks prior to the pregnancy. Then, during the first trimester pregnancy taking the drug continues.
Perhaps the purpose of supporting and higher doses, for example, patients with alcoholism, chronic infectious diseases and receiving anticonvulsants.
Overdose
No cases of overdose have not been established.
Cooperation
Simultaneous treatment with chloramphenicol, tetracycline, neomycin or polymyxins It leads to decreased absorption folic acid .
The use of folic acid reduces the efficiency of contraceptives, ethanol, sulfasalazine, glutetimid, cycloserine, methotrexate, primidina, phenytoin and so on.
Also, sometimes the reception folic acid lowers plasma levels phenobarbital, primidone and phenytoin It causes a seizure.
In addition, while reception kolestiramina from folic acid marked decrease or change in absorption. For this reason folic acid recommend to use one hour before or after 4-6 hours after admission kolestiramina .
Terms of sale
In pharmacies, the drug available without a prescription.
Storage conditions
Storage space should be protected from children, have a temperature of no more than 25 ° C.
Shelf life
5 years.
Analogs
Foliber
By analogues Folacin include: Mamifol, folic acid, B-complex, Flavinat and so on.
Alcohol and Folacin
It was found that alcohol reduces the absorption of folic acid So from its use should be abandoned.
Folacin during pregnancy
During pregnancy, folic acid is one of the most essential components of the female body. Moreover, appoint Folacin and when planning pregnancy and after its occurrence.
It was found that the component involved in the most important processes in the body: blood, the development of nucleic and amino acid metabolism, the nervous, cardiovascular and other systems.
When pregnancy folic acid prescribed for the normal formation and activity of the placenta, the development of the neural tube of the fetus and cell division. Also, this substance protects the fetus from the negative and damaging influences, prevents the development of pathologies and contributes to prosperous pregnancy.
If there is a flaw in the body folic acid , It increases the risk of preterm birth, abruptio placentae, postpartum hemorrhage, vitamin deficiency in newborns and so on. Therefore, women appointed folic acid or Folacin. Especially since both show reviews during pregnancy, the need for this matter is constantly growing, and it is possible to fully compensate for the lack of using only receiving special preparations.
Reviews of folacin
As numerous reviews about folacin, it is prescribed for women when planning pregnancy and during the first months of this charge period. Most women know that folic acid necessary as the female body, and the future of the baby, so bound by its reception, no one doubts.
Folacin also very popular in nursing mothers. Quite often, mothers of newborn babies feel very weak and tired. After passing the tests often detected deficit folic acid .
According to experts, it is a highly Folacin vitamin preparations, which is actively used in clinical practice. Its main component - folic acid It included in the essential medicines that are used in therapy and as prevention of congenital malformations of the fetus, anemic states during pregnancy and lactation.
Price Folacin where to buy
Buy drug can be in almost every Russian pharmacy. The price Folacin varies from 115 to 150 rubles.
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