Voltaren

Description overdue on 01.09.2012

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NSAIDs . The active component is Diclofenac . The drug has antipyretic, analgesic (analgesic) and anti-inflammatory effects. The basic substance indiscriminately inhibits cyclooxygenase-1, 2 It reduces the production of prostaglandins in inflammation, disorders of the metabolism arachidonic acid . The highest efficiency is noted in relieving pain of inflammatory origin. In preparation expressed antiplatelet activity . The gel form of the drug Voltaren additional analgesic effect is achieved by water-ethanol base. The drug is available in the form of ointments, gels, lotions, tablets, capsules, dragees, suppositories.

Indications:

Voltaren is prescribed for degenerative, inflammatory diseases of the musculoskeletal system: the disease Personeydzha Turner ( neuralgic amyotrophy ), Ankylosing spondylitis ( ankylosing spondylitis ) juvenile chronic arthritis   (as well as rheumatoid and psoriatic forms), rheumatism, osteoarthritis, gouty arthritis, arthritis, Reiter's disease accompanying . The drug is used for pain syndrome: tendonitis, bursitis, toothache, migraine, headache, lumbago, arthralgia, myalgia, ossalgia, sciatica, neuralgia, lumbago. Voltaren is prescribed for post-operative, posttraumatic pain syndrome , Oncological diseases, adnexitis, inflammation in the pelvis, with algodismenoree, infectious diseases of upper respiratory tract, accompanied by pain.

Contraindications:

Voltaren does not apply to a variety of violations blood clotting   (bleeding tendency, lengthening of the period of bleeding, hemophilia), in violation of hematopoiesis (anemia, leukopenia), and "aspirin triad" (intolerance acetylsalicylic acid , Pyrazolone series preparations in combination with pollinosis paranasal sinuses and nasal, bronchial asthma). The drug is not applicable in case of intolerance diclofenac, bleeding from the digestive tract, erosive and ulcerative lesions of the digestive system, breastfeeding, children up to 6 years, with carrying a pregnancy. Voltaren suppositories are contraindicated in inflammation, traumatic injury of the anus, rectum, hemorrhoids, rectal bleeding. With hypertension , Decompensated form of chronic heart failure, with diverticulitis , Diabetes mellitus, erosive and ulcerative lesions of the digestive tract, asthma , Anemia, edema syndrome, alcoholism, renal insufficiency, the elderly. Gel is not indicated in case of damage the integrity of the skin.

Side effects, overdose:

Digestive system:   diarrhea, abdominal distention . abdominal cramps , Abdominal pain, gastrointestinal bleeding without ulcers, peptic ulcers, increased liver enzymes, bloating, constipation, nausea, dyspepsia, thrush , The defeat of the esophagus, the appearance of blood in the stool, melena, jaundice, vomiting, cirrhosis gepatonekroz, hepatitis, pancreatitis, colitis. Nervous system:   anxiety, golovokrudeniya, weakness, cramps, aseptic meningitis , Irritability, double vision, depression, sleep disorders, hypersomnia. Senses:   hearing loss, taste perversion, blurred vision, scotoma Possibly irreversible hearing loss. Skin:   photosensitivity, toxic epidermal necrolysis, toxic dermatitis . eczema . hives , Alopecia. Urogenital:   fluid retention, papillary necrosis, interstitial nephritis , Oliguria, protenuriya, nephrotic syndrome, azotemia, acute renal failure. Bodies of blood:   agranulocytosis, leukopenia, thrombocytopenic purpura. Respiratory system:   laryngeal edema, bronchospasm, cough. Allergic reactions, anaphylactic shock , Congestive heart failure, high blood pressure.

In case of overdose   recorded hyperventilation , Headache, dizziness, blurred consciousness. The children observed myoclonic seizures , Irregularities in the renal and hepatic systems, epigastric pain, nausea, vomiting, bleeding. It is recommended gastric lavage, high blood pressure, seizures, through the elimination of anticonvulsant therapy . Hemodialysis and forced diuresis   We have not proved effective.

Mode of application:

Voltaren taken after a meal, the recommended dosage for adults 25-50 mg three times a day .  After achieving an optimum result gradually reduce the dosage, changing to maintenance therapy receiving diclofenac 50 mg per day .  At night you can take no more than 150 mg .  If necessary, the intravenous infusion of the drug content of 1 mg diluted in 100-500 ml of sodium chloride solution .  Infusion was carried out for 30-180 minutes, depending on the severity of pain .  Infusion "shock" of the preparation is carried out in the postoperative period for pain administered 25-50 mg for 15-60 minutes .  A further injection is carried out at a rate of 5 mg / h .  A single intramuscular injection is permissible during exacerbation of chronic diseases, in the treatment of acute conditions .  Voltaren administered rectally twice a day 50 mg or 100 mg once a day 1 .  When the first symptoms of a migraine attack rectal suppositories are administered in a dose of 100 mg .  Reintroducing held if necessary .  Outwardly Voltaren Emulgel is applied to a thin layer in an amount of 2-4 grams, lightly rubbing the gel into areas of inflammation 2-3 times a day .  The duration of therapy is 7-14 days .  After contact with the drug is recommended to wash hands under running water .

Special instructions:

Acceptance of the tablet form of the drug Voltaren half an hour before a meal provides a rapid achievement of the desired effect. Patients with disorders of the cardiovascular system, kidney diseases, elderly patients administered diclofenac with caution. Long-term treatment requires control over the work of the renal system, over fecal occult blood picture of Peripheral Blood . Voltaren affects the management of vehicles, speed of mental reactions. Voltarus emulgel only be applied to intact areas without imposing an occlusive dressing. The risk of development and manifestation systemic adverse reactions increases when applying the product to large areas of skin, especially for a long time. The gel is applied only topically, inadmissible contact with mucous membranes, eye area.

Drug Interactions:

Under the effect of increasing the concentration of diclofenac cyclosporine, digoxin, lithium Methotrexate . The medicament reduces the effectiveness of diuretics. The probability of bleeding increases when receiving thrombolytic and antiplatelet therapy. Voltaren reduces the effectiveness of sleeping pills, antihypertensive drugs; increases the toxicity of methotrexate increases nephrotoxicity cyclosporin. Tsefotenan, ceftazidime, plicamycin, valproic acid, cefamandole increase the likelihood gipoprotrombinemii. The risk of bleeding in the digestive system when assigning increased corticotrophin colchicine Ethanol, drugs St. John's wort.