Description overdue on 07/31/2014
- Latin name: Heptor
- ATC code: A16AA02
- Active substance: Ademetionine (Ademetionine)
- Manufacturer: Veropharm OJSC (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Geptor
- Contraindications
- Side effects
- Instructions for use Geptor (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Tablets are composed INN S-adenosylmethionine (based on ademetionine ). Also, it includes a number of additional substances MCC polyplasdone X E-10 (crospovidone), magnesium stearate, mannitol.
Product form
The drug is available in tablet form, which covers yellow shell dissolves in the intestine. When cross-sectional view two layers. The tablets are packaged in blister pack of 10 pieces in a cardboard box is placed 1 or 2 of the blister. Tablets also implemented in banks of polymer or dark glass, which is packaged in 20, 40 or 50 tablets.
Also, the drug produced in the form of a freeze-dried product, from which the solution is being prepared. It is administered intravenously and intramuscularly. The drug contained in a vial which is packed in a cardboard box.
Pharmacological action
Geptor a hepatoprotective agent, which, moreover, has the effect of antidepressant. On the body is a means of providing a regenerating, antioxidant, detoxification, antifibroziruyuschee, neuroprotective effects.
The active ingredient is a means of ademetionine . This substance is involved in several biochemical processes in the body, it stimulates the production of endogenous ademetionine. This substance is, in tissues, and in body fluids. It is involved in the biochemical reactions. Also ademetionine is a precursor of polyamines, including putrescine, stimulating cell regeneration and proliferation of hepatocytes.
Pharmacodynamics and pharmacokinetics
A preparation in the form of film-coated tablets which dissolves in the intestines, therefore, the active substance is released directly into the duodenum. After oral administration the bioavailability equal to 5%. The maximum drug concentration is observed after 2-6 hours after the patient takes his dose in the 400 mg dose.
The active ingredient is only slightly bound to plasma proteins. In the cerebrospinal fluid of a high concentration of the drug. The active substance penetrates through the BBB.
Biotransformation agent occurs in the liver. Excreted from the body by the kidneys, the half-life is 1.5 hours.
Indications Geptor
Indications for use of the drug as follows:
- Treatment of patients with intrahepatic cholestasis ;
- cirrhosis of the liver , Pretsirroticheskie state;
- treatment hepatitis various origins, including toxic, drug, and viral hepatitis;
- encephalopathy secondary genesis;
- the development of alcohol withdrawal syndrome;
- depressive syndrome.
Contraindications
The drug is not assigned if the patient is marked intolerance to a specific component of the drug. Be wary of people being treated Geptor diagnosed with cirrhosis of the liver, associated with hyperasotemia. In this case, treatment is carried out only if the continuous control of nitrogen content in the blood plasma.
Side effects
As a rule, Geptor well tolerated. Only in some cases in the treatment marked discomfort in the epigastrium associated with the acidic pH of the active substance. Typically, this side effect disappears on its own and does not require discontinuation of treatment or adjunctive therapy by other means. Rarely can develop allergic reactions.
Instructions for use Geptor (method and dosage)
Before taking this medication Geptor instructions for use should be read carefully. The tool is administered orally, it is desirable to swallow the tablet whole without chewing or crushing them. Remove the tablet from the package should be immediately before the reception. Instructions for use Geptor provides that for maximum effect, it is desirable to take Geptor between meals.
How long the treatment should last, determined by the physician, taking into account the patient's condition. For the maintenance treatment of adults is assigned from 2 to 4 tablets daily. They need to be taken in divided doses.
On average, the treatment agent lasts from 2 to 4 weeks. If there is such a need, it can be assigned to a second course of treatment. Geptor pills and capsules should not be used in the evening, as there may be a tonic effect on the body means.
Overdose
There is no evidence of drug overdose Geptor.
Cooperation
No information about the manifestation of drug interaction tools.
Terms of sale
Pharmacies Geptor sold by prescription.
Storage conditions
Keep tablets should be in the original packaging, Protect them from direct sunlight. The temperature should be between 15 to 25 degrees.
Shelf life
Geptor can be stored for 2 years.
Cautions
Due to the fact that the drug has a tonic effect, the means should not be used at bedtime.
If this drug treatment prescribed to people suffering from cirrhosis of the liver in the background hyperasotemia, it is necessary to provide precise control of the nitrogen content in the blood.
Special shell tablet dissolves only in the intestine, so release of the active agent occurs after contact with the tablet into the duodenum.
People with bipolar disorder, the treatment can be induced ademetionine inversion of affect.
When treating Geptor not marked effect on a person's ability to drive vehicles and work with the precise mechanism.
Synonyms
Geptral.
Analogs Heptral
Elkar
Geptral
Carnitine
Analogs Geptor drug - this drug Geptral and Adenosylmethionine Having similar effects on the body of the patient.
Is it better or Geptor Geptral?
And Geptor and based in Geptral have similar active ingredient - ademetionine. Therefore, their effects on metabolism in the liver and brain virtually identical. Geptral realized in the form of tablets and injections for intravenous and intramuscular administration. The main differences - the manufacturer and the cost of these drugs. Geptor - domestic production of the drug. Geptral produced in Italy, respectively, its cost is higher.
Babies
Not applicable for the treatment of children and adolescents under 18 years of age.
During pregnancy and lactation
In the first two trimesters of pregnancy can not be used Geptor. In the third trimester agent may be appointed only in the event that such a decision is taken by the attending physician. It is important to regularly and very precisely monitor the health of the mother and fetus. In the months feeding woman can practice Geptor treatment only after the prescribing physician, who decides whether to continue breast-feeding.
Reviews Geptor
Visiting a specialized forum or website, you can find numerous reviews about Geptor. Patients noted as an advantage of the relatively low cost of the drug, as well as ease of use. Reviews doctors suggest a positive effect after a course of treatment. Improvement of the notes in the course of treatment, however, be sure to adhere to the treatment regimen that was prescribed by a doctor.
Price Geptor where to buy
In almost any pharmacy you can buy pills Geptor, their price ranges from 600 to 800 rubles for 20 tablets. Price Geptor ampoules average of 1250 rubles per 5 pieces. Buy shots can be freely in all Russian cities.
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