Flosteron

Description overdue on 11/25/2014

• Latin name: Flosteron
• ATC code: H02AB01
• Active substance: Betamethasone (Betamethasone)
• Manufacturer: DD Krka, Slovenia

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Flosterona
• Contraindications
• Side effects
• Instructions on Flosteron (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

One milliliter of suspension contains betamethasone disodium phosphate - 2 mg betamethasone dipropionate - 5 mg plus excipients (sodium chloride, polysorbate 80, methyl paraben, sodium carmellose, concentrated hydrochloric acid, sodium hydrogen phosphate dihydrate, sodium edetate, benzyl alcohol, propylparaben, polyethylene glycol, purified water for injection).

Product form

The drug produced in the form Injectable suspensions As well as ampoules   1 and 5 ml ampoules in a contour package (a carton box).

Pharmacological action

Immunosuppressive, anti-inflammatory.

Pharmacodynamics and pharmacokinetics

Active substance means - glucocorticosteroid   (synthetic analog of adrenal hormones) has antirheumatic, anti-inflammatory and immunosuppressive effects.

Betamethasone   It is acting on the energy metabolism, glucose homeostasis On the selection and activation of hypothalamic factors nutritional hormone from adenohypophysis .

Mechanism of action GCS   to date it is not yet fully understood. It is believed that the process is carried out at the cellular level. It is believed that cytoplasm   There are two receptor systems. Action betamethasone   made with special GCS receptors . Mineralocorticoid receptor   in turn regulate water and electrolyte balance   and sodium potassium metabolism .

Corticosteroids   - The fat-soluble substance, which can easily penetrate through the cell membranes into the target cell . The action of the drug is based on the subtle biochemical processes occurring at the molecular level.

Betamethasone dipropionate   longer absorbed and provides a prolonged effect of the drug.

Depending on the manner in which vehicle was administered into the body, it is possible to achieve a general or local (local) effects.

Indications Flosterona

Injections Flosterona appoint:

• at burns, traumatic, surgical, toxic, anaphylactic, cardiogenic   and transfusion shock ;
• at anaphylactoid reactions ;
• at swelling of the brain ;
• for the treatment of severe asthma ;
• in systemic connective tissue diseases ( lupus erythematosus, thyrotoxic crisis, hepatic coma, rheumatoid arthritis );
• for the prevention of scarring and inflammation in poisoning cauterizing liquids.

A number of other indications for use:

• at articular rheumatism . synovitis . epikoshshlite . peritendinitis . myositis . fibrositis . lumbago , Posttraumatic osteoarthritis ;
• treatment asthma , Seasonal or chronic rhinitis ;
• psoriasis . keloid . contact atopic dermatitis ;
• insect bites;
• treatment ulcerative colitis ;
• at kollagenozah ;
• ceteris allergic reactions .

Contraindications

The drug is not prescribed:

• at osteoporosis . tuberculosis . glaucoma ;
• stomach ulcer . diverkulite ;
• at thrombophlebitis   and diabetes ;
• if there are sharp Viral . Fungal   or Bacterial   infection and the required treatment is not carried out;
• after a major operation or injury;
• at Cushing's syndrome ;
• during the period of 2 months before or within 2 weeks after Vaccination ;
• not administered intramuscularly   at idiopathic thrombocytopenic purpura ;
• If signs of inflammation in the joints are missing;
• during deformation, and bone destruction   joint (including as a result of the fracture);
• instability in the joint;
• the drug should not be administered in the tendon;
• bleeding caused by reception anticoagulants   or congenital;
• children up to 3 years;
• lactating women;
• hypersensitivity to any component of the agent.

Caution must be exercised cirrhosis . Chronic renal failure . chronic hepatitis At psychosis   and psychoneurosis , Sick AIDS   or HIV , Heart failure, recent adjourned myocardial infarction Under strong obesity . polio At asthma . pregnancy   or thromboembolism .

Side effects

The type and frequency of adverse reactions depends on the duration of treatment, the dosage and rate assignment.

May occur:

• from aharny diabetes   (a steroid), dysfunction adrenal (up by almost complete suppression) from INDRA Cushing . amenorrhea . striae , Increasing Blood Pressure ;
• children - a delay in sexual development;
• pancreatitis . erosion , Nausea, duodenal ulcer , Decreased appetite, hiccough . flatulence ;
• candidiasis   in the mouth and throat, pain in epigastric , Vomiting, bleeding from the gastrointestinal tract;
• osteoporosis . myopathy , Ruptures of muscles and bone fractures, slow process of bone formation in children, atrophy   muscles, muscle weakness of the skeleton;
• arrhythmia . heart failure . increased blood pressure . bradycardia , Cardiac arrest, characteristic changes electrocardiogram ;
• depression . euphoria . paranoia   and hallucinations , Violation of sleep, dizziness . headache ;
• hyperpigmentation . candidiasis , Thinning of the skin, striae , acne, petechiae . hypopigmentation . ecchymosis ;
• increase in seizure activity, affective insanity , Increased intracranial pressure;
• obesity . swelling . hypernatremia . hypokalemia . hypocalcemia ;
• skin rash, itch . bronchospasm , Other allergic reactions ;
• leukocytosis , back pain, leukocyturia . opportunistic infections .

In patients with subacute or acute myocardial infarction   deterioration can be observed: the spread Necrosis   in cardiac muscle, until break, vein thrombosis , Slowing the process of forming scars.

At the site of injection means may be numbness, pain and burning, necrosis . atrophy   skin and subcutaneous tissue.

Instructions on Flosteron (method and dosage)

Depending on the severity and nature of the disease, the dosage may vary significantly.

Injections Flosterona, instructions for use

For systemic effects on the body, usually administered by intramuscular injections. The drug is injected deep into the gluteal muscle at 0, 1 - 0, 2 ml every six months - a month.

In the event of acute allergic reactions produced by intramuscular injection of 1-2 ml of funds once.

For topical administration, the dosage may vary substantially, depending on the size of the affected area. It generally ranges from 0 25 to 2 ml. Multiplicity of reception is the same as when using the system.

Also, a drug injected directly into the joint (intra-articular) or periarticular:

• pelvic joint - on 0, 1-0, 2 ml;
• grudinnoklyuchichny, interfalangovy and metacarpophalangeal - to 0, 5 ml;
• in the knee, ankle, shoulder - to 0, 1 ml;
• wrist and elbow - 0, 5 - 1 ml.

Also common in the intradermal route of administration psoriasis, eczema, atopic dermatitis   etc. A single dose should not exceed 0, 2 ml per m of the surface, can not be administered during the greater than 1 ml of the preparation.

If necessary (for pain relief) medication can be mixed in the same syringe with lidocaine   or procaine   (one percent solution).

For children from 3 to 5 years initial dosage of 0, 3 ml, 6 to 12 - 0, 6 ml.

Overdose

Overdose symptoms Flosteronom: vomiting . nausea . euphoria, depression, insomnia .

If you take extra-large doses for a long time may develop osteoporosis, myopathy, increased blood pressure, Cushing's syndrome .

If an overdose can not abruptly stop taking money. The dosage should be gradually reduced, until the complete withdrawal of the drug to maintain vital functions of the patient to produce symptomatic treatment. It should be used drugs lithium, phenothiazines, antacids, aminoglutethimide .

Hemodialysis   ineffective, specific antidote   formulation has not.

Cooperation

Combination with ethanol   and NSAIDs   It increases the risk of ulcers in the stomach and bleeding.

Simultaneous use GCS   and beta2-agonists   increased risk of hypokalemia .

Precautions combined means:

• from amphotericin B . inhibitors karbangidrazy ;
• from Paracetamol, rifampicin, phenobarbital, primidone, carbamazepine, phenytoin, ephedrine, aminoglutethimide   (due to lower efficiency GCS) ;
• from Ritodrin (pulmonary edema);
• from live vaccines   (increased risk of viruses);
• from immunosuppressants, carbutamide, Mr. holinoblokatorami, tricyclic antidepressants, glycosides ;
• from antipsychotics . Azathioprine . antihistaminics . Nitrates   (may increase intraocular pressure) digitalis glycosides   ( hypokalemia ).

Effectiveness Growth Hormone . antidiabetic drugs . Praziquantel . Albendazole . anticoagulants, kaliuretikov   and natriuretikov   when combined with a drug is greatly reduced.

Due to the fact that renal clearance of salicylates When combined with means for substantially accelerated achieve their therapeutic concentration becomes almost impossible.

It does not take GCS   and androgens . anabolic steroid . oral contraceptives   and Estrogens Due to the increased risk of adverse reactions.

When combined with asparaginase   and cyclosporine   Toxicity means increases.

Simultaneous reception inhibitors of the adrenal cortex   ( miotan ) from GCS   It requires an increase in dosage Steroids .

Hyperglycemic effect   from streptozotocin   It becomes more pronounced.

Terms of sale

We need a recipe.

Storage conditions

The preparation is stored in a cool place, for which there is no access to young children.

Shelf life

3 years.

Cautions

The medicine was injected intravenously impossible.

Introduction into or around the joint should be done by.

When local use is a risk of systemic adverse reactions.

In the course of therapy should closely monitor the condition of the patient, monitor blood counts, water and electrolyte balance . glycemia .

The drug can be mixed with the local anesthetics   in one syringe (not in the vial).

During treatment, medication should operate machinery and car.

It should be remembered that 0, 6 mg betamethasone   equivalent to 20 mg hydrocortisone 4 mg triamtsinalona or methylprednisolone .

Before applying the medication to joints should produce research synovial fluid To exclude the presence of sepsis . If observed after treatment chills, fever , Swelling and impaired joint mobility, increase in temperature, should be appointed antibiotics . When intercurrent infections, tuberculosis, sepsis   also need to prescribe antibiotics.

If the patient is not sick before varicella , Your risk during therapy steroids   It increases considerably. It should generate a passive immunizations .

In patients suffering from diseases of the liver or hypothyroidism,   may increase exposure GCS on the body.

Analogs

Match code ATC 4th level:

• Depo-Medrol
• Medrol
• Solu-Medrol
• Diprospan
• Kenalog

The closest analogues: Betaspan Depot, Beloderm, Diprospan, Betazon, Betaspan, tselestoderm-in, mesoderm, Betamethasone, Lorakort , Soderm, Tseleston, Hydrocortisone .

Is it better or Diprospan Flosteron?

The active ingredient is the same in both preparations, a similar composition. However, the cost Flosterona much smaller than its counterpart. Many write flattering reviews Diprospan , With "abusing" the original, write, that it is less effective. However, everything is very individual. In any case, the question of replacing one drug to others should be decided after consultation with the attending physician.

Reviews Flosterone

Reviews Flosterone forums

According to reports from different patient groups, we can conclude that the drug is very effective and at the same time "severe." Often the side effects occur primarily dizziness, thinning skin, malaise, weight gain . Judging by the reviews people are basically afraid to take any GCS For fear of adverse consequences. In this situation, you should trust your doctor and strictly follow the recommendations on the admission of the drug.

Price Flosterona

Price injections Flosterona is about 200 rubles for 5 vials of 1 ml.

Get the best price and buy