Description overdue on 10/11/2014
- Latin name: Vitae-Melatonin
- ATC code: N05C H01
- Active substance: Melatonin (Melatonin)
- Manufacturer: Kiev Vitamin Plant
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use Vita-melatonin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As a part of Vita-melatonin It contains the active ingredient melatonin As well as additional ingredients, microcrystalline cellulose, milk sugar, potato starch, calcium stearate.
Product form
Vita-Melatonin is available in tablets of 3 mg of which the package contains 10 pieces. or 30 pcs.
Pharmacological action
Vita-Melatonin - it is synthetic analogue of hormone Melatonin , Who in the body is produced epiphysis and determines the the process of inhibition generation of gonadotropins. Also, under the influence of of melatonin in the somewhat lesser extent it is happening elaboration of thyrotropin . corticotropin . somatotropin . In the hypothalamus, midbrain, and increases the amount GABA and Serotonin . As a result of these processes is restored normal rhythm of sleep and wakefulness, increased performance, mental and physical activity.
Tablets also have antioxidant and membrane-stabilizing effect. The active ingredient helps to normalize the permeability of the vessel walls, increases their resistance, has immunomodulatory effects on the body.
Melatonin reduces blood pressure and heart rate in elderly people, leads to normal autonomic nervous regulation of the cardiovascular system.
Pharmacokinetics and pharmacodynamics
After ingestion occurs expressed Vita-melatonin metabolism during its first pass through the liver. The level of bioavailability is 30-50%. The highest concentration in the blood and saliva observed after 20 and 60 minutes after dosing. Active substance permeates through the GEB. The time of its half-life is approximately 45 minutes. Excreted eliminated via the kidneys.
Indications
Vita-Melatonin is indicated for patients in the following cases:
- With the purpose of treatment and prevention of disorders daily rhythm of, related with fast change of timezones, as well as of fatigue, associated with the origin in such movements.
- For the treatment of a variety of sleep disorders, including chronic insomnia Having a functional origin, in particular, insomnia in elderly patients.
- In order to enhance the mental and physical activity, to reduce the severity of the reactions after stress and doldrums Associated with seasonality.
- Also appointed at elevated blood pressure and hypertensive disease at stage I-II in the elderly part of complex treatment.
Contraindications
Defines such contraindications for treatment means:
- high sensitivity melatonin and other components of the tablet;
- autoimmune diseases;
- myeloma, Hodgkin's disease, lymphoma, leukosis ;
- diabetes ;
- epilepsy ;
- pregnancy and period breastfeeding ;
- children's age;
- It should not be taken at the same time with the treatment of GCS inhibitors, MAO cyclosporine.
Side effects
Perhaps the development of the following side effects in the treatment Vita-Melatonin:
- irritability, feeling of anxiety, insomnia, depression, high excitability;
- It is very early awakening the morning;
- enhancement of sexual desire;
- sweating at night, dermatitis ;
- weight gain;
- migraine . constant sleepiness . dizziness ;
- constipation , Abdominal pain, mouth sores and dry mouth.
In rare cases, there is:
- vomiting, flatulence , Gastroesophageal reflux disease;
- impaired attention, poor sleep;
- reduced vision, watery eyes;
- flushing;
- hypocalcemia, hypertriglyceridemia, hyponatremia;
- thrombocytopenia, leukopenia;
- angina , Increased heart rate;
- hyperbilirubinemia;
- erythema, dryness and itching of integuments ;
- pain in extremities, muscle cramps;
- proteinuria, glycosuria;
- chest pain, asthenia.
Instructions for use Vita-melatonin (method and dosage)
Instructions on Vita-Melatonin provides that the drug is given to adult patients a daily dose of 3-6 mg, that is 1-2 tablets. Take it should be 30 minutes before bedtime. Instructions for use shows that it is desirable to take the drug on a daily basis at the same time. Duration of treatment is determined individually, mainly therapy lasts for as long as the rhythms of wakefulness and sleep is not normal. As a rule, the treatment lasts about one month.
To prevent the tablets should be taken within 2 months.
With the aim of treatment of chronic sleep disorders Elderly patients administered on 1, 5 mg at bedtime once daily. If the effectiveness of such treatment is not sufficient, the dose is increased to 3 mg. The drug should be withdrawn gradually reducing the dosage. With increased pressure treatment duration can be up to 6 months, and the duration between treatments in 1 month is necessary to make a break for 1 week.
Overdose
If an overdose of Vita-melatonin (overdose is possible when taking 24 mg), the patient may experience a long sleep, a state of disorientation, loss of recent memory. Symptomatic treatment.
Cooperation
Simultaneous treatment with drugs that block the β-adrenergic receptors, and Dexamethasone . clonidine . fluvoxamine possible changes in the secretion of endogenous melatonin.
Probably the effect of Vita-melatonin on the degree of effectiveness of hormonal methods.
Possible potentiation of the antitumor effects of tamoxifen, as well as an antibacterial effect Isoniazid .
Perhaps increased dopaminergic and serotonergic influence of methamphetamine while taking these drugs with Vita-melatonin.
Fluvoxamine can increase the level of melatonin in the body.
It is important to continuously monitor patients who receive estrogen, as this may increase melatonin levels due to the slowing down its metabolism.
Carbamazepine, rifampicin provoke a decrease melatonin levels in the blood.
Terms of sale
The tool can be purchased at a pharmacy for a prescription.
Storage conditions
Stored in the original containers at room temperature, the tablets should be protected from children. You can not use after their expiry date.
Shelf life
Vita-Melatonin can be stored for 3 years.
Cautions
Because melatonin has some contraceptive effect on the body, the drug should not be taken for women who plan to become pregnant.
In the period of of treatment pills need to to avoid too bright lighting.
People suffering cirrhosis of the liver Metabolism of melatonin decreases, thus taking it to such people should be cautious.
If long-term treatment Vita-melatonin reduces cholesterol levels in people with hypercholesterolemia. Under the influence of the drug lowered levels insulin and Glucose in blood.
Careful preparation is assigned if the patient hormonal disorders, as well as during hormone treatment. Also caution should be appointed agent for allergies patient.
Vita-Melatonin may cause drowsiness, so to drive traffic and engage in potentially hazardous activities such treatment is not recommended.
Analogs
Melaxen
Tsirkadin
Analogs Vita-melatonin tablets - medication Tsirkadin . Melaxen . Melatonin et al., which have the same indications for use. All medications patients can take only after the appointment of a specialist.
Babies
There are no data on the use of the drug for the treatment of children and the safety of such therapy.
With alcohol
During treatment Vita-Melatonin alcohol use is undesirable, since alcohol reduces the effectiveness of the drug.
During pregnancy and lactation
Do not assign these tablets for the treatment of women during gestation and breastfeeding.
Reviews of Vita-Melatonin
Reviews of this preparation in the network are found mostly positive. They noted that when taking Vita-Metatonina really normal sleep. During treatment accelerates the process of sleep, biological rhythms are normalized. Side effects are rare. In some a review, it is mentioned state of of weakness and dizziness. But in general reviews of the Vita-Melatonin positive.
Price Vita-melatonin, where to buy
Price Vita-melatonin tablets on average 250 rubles. In Ukraine, the drug can be bought at the price of 45 hryvnia for 30 tablets.
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