Description overdue on 11/26/2014
- Latin name: Cefix
- ATC code: J01DD08
- Active substance: Cefixime trihydrate
- Manufacturer: Pharma International Co, Jordan
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Cefixime, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
One capsule 200 mg comprises cefixime trihydrate dose of 200 mg. Accordingly, one capsule contains 400 mg of active substance 400 mg. As additional substances is used: sodium lauryl sulfate, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, hydrogenated vegetable oil.
Five milliliters suspension Cefix (children) contains 100 mg of cefixime trihydrate . As additional substances used: croscarmellose sodium, xanthan gum, sodium benzoate, citric acid monohydrate, microcrystalline cellulose, carboxymethylcellulose sodium, flavor, sucrose.
Product form
Medicament cefixime available in capsules of 400 and 200 mg, and as a powder for oral suspension dosage of 100 mg / 5 ml in vial 30 ml and 100 mg / 5 ml in a vial of 60 ml.
Pharmacological action
Cefixime in any form of release, including slurry to children, has high stability to the presence of beta-lactamase - Enzymes, which are aimed at combating beta-lactam antibiotics ( cephalosporins and etc.). As a result, resistant to penicillins and cephalosporins Many organisms due to the presence of beta-lactamase, can be susceptible to active drug substances.
The antibiotic cefixime has an impact on virtually all strains of various microorganisms, including:
- Gram-positive microorganisms: pneumococcus . Streptococcus . pyogenes .
- Gram-negative bacteria: Haemophilus infection (beta-lactamase positive and negative strains) Moraxella (Branhamella) catarrhalis (most of which are beta-lactamase positive) Escherichia coli , Proteus Mirabilis . gonococcus , including Penicillinase .
Note: Pseudomonas species, strains of group D streptococci (including Enterococci ) listeria Most strains staphylococci (including methicillin-resistant strains), and most strains of Enterobacter resistant cefixime trihydrate .
Pharmacodynamics and pharmacokinetics
Medicament characterized by rapid absorbability in the digestive tract, regardless of the dietary formulation adopted or not. Bioavailability, including children is 30-50%. At the maximum concentration of active agent is achieved within 2 - 6 hours after oral administration of one capsule of 200 mg, 400 mg or suspension in an amount that depends on the age and the severity of the disease. Approximately 50% of the dose of the drug is excreted unchanged in the urine during the day. Also, cefixime trihydrate It can be partially excreted in bile.
In patients with moderate abnormalities in the kidneys (20 - 40 ml / min for creatinine clearance), 50% of cefixime trihydrate may be derived from an organism to 6, 4:00. In severe renal insufficiency (5 to 20 ml / min for creatinine clearance) the half-life is increased to an average of 11, 5 hours.
Indications
Means prescribed for the treatment of the following diseases:
- uncomplicated urinary tract infections ;
- acute intestinal diseases ;
- otitis media ;
Also, the drug is prescribed for the treatment of diseases caused by pneumococci and Streptococcus pyogenes :
- pharyngitis . sinusitis and tonsillitis ;
- acute bronchitis and exacerbation chronic bronchitis ;
- acute pneumonia .
Contraindications
Cefixime in any form of release is contraindicated in people who have been allergic to the group of antibiotics cephalosporins .
Also, the drug should not be used when porphyria .
Children under 12 years of taking the drug is contraindicated in the form of capsules and syrup for children is not recommended for use before 6 months.
Warning: Before using cefixime as a drug you should consult with your doctor.
Side effects
The majority of adverse reactions observed in clinical trials of the drug were mild and temporary. The most frequent side effects are:
- Gastrointestinal disorders : Very rare cases while taking the drug can be observed diarrhea , Abdominal pain, nausea . dyspepsia and flatulence .
- Skin reactions : rash . hives and itch .
- CNS disorders : headache and dizziness .
- Violations of the lymphatic system : transient thrombocytopenia . leukopenia and eosinophilia .
In addition to these side reactions can occur rarely renal dysfunction . toxic nephropathy , Abnormal liver function, aplastic and hemolytic anemia . colitis .
Cefixime, instructions for use (method and dosage)
The drug is in the form of capsules is recommended to be taken with food. Children aged 12 years and adults is assigned to daily dose of 400 mg. The course of treatment is determined by a specialist depending on the age and severity of disease. Children under the age of 6 months drug is administered as a suspension.
In patients with a creatinine clearance of between 21 and 60 ml / min, the dose should be reduced to 300 mg per day. Patients with creatinine clearance less than 20 mL / min, the dose should be reduced to 200 mg per day.
The suspension of cefixime, instruction for children
Children from 6 months to 12 years of cefixime administered in a dosage rate of 8 mg / kg body weight of the child once a day or 4 mg / kg body weight - twice a day. The duration of dosing is determined by the physician on an individual basis.
Children aged 12 years old drug is given at a dose of 400 mg / day, 1 time or 200 mg 2 times.
Overdose
With an overdose of these agents can be observed nausea . dizziness . vomiting . generalized weakness . diarrhea .
Cooperation
Nephrotoxicity described the drug increases while taking the drug with Furosemide and aminoglycosides .
The duration of the prothrombin time with the clinical manifestations or without bleeding, may be increased when used with cefixime anticoagulants .
During the reception of the drug consumed alcoholic drinks is strictly forbidden.
Terms of sale
The drug is in all forms of release is released only at the pharmacy on prescription.
Storage conditions
Cefixime in form capsules and powder should be kept at a temperature no higher than 25 ° C, in the form of A suspension of - In the refrigerator no longer than two weeks.
Shelf life
Up to 3 years.
Analogs of cefixime
Tseforal Soljutab
Pantsef
Klaforan
Cefodox
Supraks Soljutab
Ceftriaxone
On the composition of the active ingredients and the form of cefixime to peers include: Vinex . Ikzyme . Lopraks . Cefixime (all of these preparations are available in powder form).
Analogs of the drug in capsule form: Supraks Komfortab . Supraks Soljutab . Vinex . Lopraks . Flamifiks .
Reviews of cefixime
Due to the fact that cefixime can treat children up to 6 months and 12 years, reviews of the suspension for the children often leave the mother. According to most mothers, cefixime in form of capsules and suspensions when receiving no longer than 7 days does not cause any adverse reactions, and the treatment is very effective, especially in the case of tracheitis and other respiratory diseases.
Price cefixime
Depending on the form of cefixime price varies from 100 to 140 hryvnia. The price of cefixime counterparts - from 80 to 120 hryvnia.
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