Description overdue on 02/12/2014
- Latin name: Lincomycin
- ATC code: J01FF02
- Active substance: Lincomycin (Lincomycin)
- Manufacturer: Synthesis OAO, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications Linkomitsina
- Contraindications
- Side effects
- Instructions for use Linkomitsina (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Antibiotic Lincomycin It is composed of active substance linkomitsin and a number of auxiliary ingredients.
Part ointment lincomycin-Akos included linkomitsin Shaped hydrochloride.
Product form
Product form preparation - capsule and the solution contained in ampoules. The package may be 6, 10, and 20 capsules of 250 mg. The ampoules can contain 1 ml or 2 ml of solution.
Ointment lincomycin-Akos sold in tubes of 10 and '15
Pharmacological action
The antimicrobial agent that belongs to the group of lincosamides. It is noted for his influence bacteriostatic against a broad spectrum of microorganisms. If the practice of the use of higher doses, it can produce a bactericidal effect.
The mechanism of antimicrobial effect of the antibiotic is as follows: under its influence is inhibited protein synthesis in cells of microorganisms. It has pronounced activity against Gram-positive aerobic and anaerobic microorganisms. Resistance to demonstrate the influence of the strains of Enterococcus faecalis, as well as viruses, fungi, protozoa. Also, resistance to it, most of gram-negative microorganisms. Noting the slow development of resistance to this agent. Marked cross-resistance of a given substance with clindamycin.
Pharmacokinetics and pharmacodynamics
After oral administration of lincomycin hydrochloride is absorbed from the gastrointestinal tract quickly. About 50% of the substance reaches the systemic circulation. The plasma protein binds to 75%, the highest concentration is observed after 2-4 hours after oral administration. The substance enters the fluid and organ tissues. The highest concentrations occur in saliva, kidneys, genitals, liver, cardiac muscle, bone tissue, bronchial secretions. Able to penetrate the blood-brain barrier, it is excreted in breast milk. Metabolism occurs primarily in the liver, are excreted with feces leaves, a small amount is excreted in urine as metabolites and intact. Half-life of the body - 5-6 hours, it grows in people with kidney disease.
Indications Linkomitsina
Tablets lincomycin and injections Linkomitsina appointed the following diseases:
- bone and joint disease of an infectious nature, the development of which provoked a sensitive means to microorganisms ( osteomyelitis . septic arthritis );
- Infectious diseases of upper respiratory tract and respiratory tract, triggered by susceptible organisms (if applicable sore throat At sinusitis . otitis . bronchitis . pneumonia . tracheitis and etc.);
- diseases of the skin and soft tissues, which provoked sensitive means of micro-organisms ( abscess . sores . mastitis . furunculosis . mug and etc.).
- Lincomycin-Akos topically applied in inflammatory and purulent diseases of soft tissues, the skin, which were provoked by microorganisms sensitive to the active ingredient.
Lincomycin is used in dentistry for the treatment of purulent and infectious processes that occur in the oral cavity. In particular in dentistry lincomycin can be administered in the treatment of periodontitis . periodontitis . gingivitis . pyogenic abscesses et al. Is there evidence for the use of lincomycin, dentist determines individually.
Contraindications
Do not use in therapy the drug to people who have a high sensitivity to antibiotics belonging to the group of lincosamides. Not used to treat patients with severe diseases of the kidneys and liver. Not used for the treatment of children up to 6 years of age.
Side effects
In applying Linkomitsina ampoules and capsules patients may experience these side effects:
- abnormalities in the gastrointestinal ( vomiting , Pain, nausea , Violation of a chair, an increase in liver enzymes, esophagitis . hyperbilirubinemia );
- disturbance of blood ( thrombocytopenia . agranulocytosis . neutropenia . pancytopenia );
- allergic processes ( itchy skin . hives . rash . swelling Multiforme erythema . anaphylactic shock );
- muscle weakness, headache . arterial hypertension . dizziness .
If any side effects should immediately tell your doctor.
Instructions for use Linkomitsina (method and dosage)
If the patient were assigned injections Linkomitsina , Instructions for use during treatment should be carefully observed. A preparation in capsules may be administered intravenously and intramuscularly. The daily dose of the agent for an adult should not exceed 1, 8 g, if the disease is difficult, the doctor may increase it to 2, 4, the agent is administered three times a day, with honey injection interval of 8 hours. Babies agent should be administered at a rate of 10-20 mg per 1 kg of body weight per day. Lincomycin / in drip administered before administering the solution is diluted with isotonic sodium chloride solution.
When infectious diseases are appointed as Lincomycin Capsules . Instructions for applying are encouraged to take the drug in capsule in angina, as well as in the sinus or 1 hour before meals or 2 hours after its reception. Tablets should not be chewed, they must be swallowed whole, washed down with plenty of. The drug tablets should be taken at regular intervals, dividing his daily dose. Children whose weight exceeds 25 kg, the daily dose must be determined at the rate of 30 mg n means 1 kg of weight.
When used in dental medicine, as well as in the treatment of other infectious diseases, usually assigned Lincomycin 500 mg three times a day. In severe symptoms, the dose may be increased up to four-time receiving 500 mg of the drug. Typically, the treatment lasts from 1 to 2 weeks. Sometimes treatment duration of up to 3 weeks (for example, osteomyelitis ). If the patient has impaired liver function or renal function dosage should be adjusted individually.
Externally appointed ointment lincomycin . Instructions for use shows that the ointment lincomycin-ICCO should be applied directly into lesions with a thin layer. We perform this procedure must be 2-3 times a day.
Overdose
No data on cases of acute drug overdose. If you take it for a long period and in high doses, there may be a manifestation of pseudomembranous colitis and Candida infection . In this case, drug treatment should be suspended.
Cooperation
Unless antibiotic applied simultaneously with non-steroidal anti-inflammatory drugs, the patient increases the likelihood of developing respiratory failure, may stop breathing.
Receiving both lincomycin and antidiarrheal agents increases the likelihood of developing pseudomembranous colitis.
You can not treat the drug at the same time with the use of muscle relaxants and volatile anesthetics.
The absorption of the antibiotic reduced while taking drugs absorbent.
Lincomycin reduces the severity of the action neostigmine . pyridostigmine . ambenoniuma .
Bacteriostatic antibiotic exposure is reduced while taking Erythromycin and chloramphenicol .
There pharmaceutical incompatibility kanamycin . novobiocin . Ampicillin .
Terms of sale
The drug is sold by prescription.
Storage conditions
Store the product in the form of solution, capsule and ointment need in dry and dark place, at the same temperature should be 15-25 degrees Celsius.
Shelf life
Keep the drug can be 4 years. Shelf life of lincomycin-Akos - 2 years.
Cautions
If a patient has impaired kidney function, liver, it reduces the single dose of 1 / 3-1 / 2, and the interval between administration increases. Prolonged treatment with antibiotics is necessary to check your liver and kidneys.
If a patient kidney or liver failure The drug is contraindicated from what lincomycin may be imposed only for health reasons.
If the patient is prescribed pills lincomycin, from which later develops as a side effect pseudomembranous colitis, the drug is removed immediately, and appointed bacitracin or Vancomycin .
Topical ointment carefully appointed at ringworm .
The solution should not be administered intravenously quickly
Analogs
Lincomycin hydrochloride
Clindamycin
Analogs of the antibiotic lincomycin - a drug Lincomycin hydrochloride . Linkotsin Clindamycin . Dalatsin C . Clindamycin Norton and etc.
Use other drugs patients receiving lincomycin, without prior approval of the physician is strictly prohibited.
Babies
It allowed the appointment of antibiotics to children after reaching the age of 6.
With alcohol
In discussing the compatibility of this antibiotic with alcohol, it should be noted that the alcohol in the treatment of this medicine should not be consumed. This combination disturbed absorption of the active substance in the gastrointestinal tract drug, under the influence of alcohol on the liver has accelerated half-life of the active substance. Consequently, the concentration of drug in the body decreases, and decreases its efficiency.
Furthermore, if the patient combines lincomycin and alcohol effects may be negative, because it increases the likelihood of side effects.
During pregnancy and lactation
During pregnancy and lactation the drug should not be used to treat. Acceptable Drug Administration in the second and third trimesters of pregnancy, but only in the presence of vital signs.
Reviews of lincomycin
Reviews of lincomycin, which people leave the network, suggest that this drug has a pronounced anti-microbial influence and allows you to quickly get rid of the unpleasant symptoms of infectious diseases. Those who used injections lincomycin, reviews and leave mostly positive.
Both intravenous and intramuscular administration solution works rapidly and reduces the severity of symptoms. Reviews on the use of funds in dentistry often contain information that the drug helped to quickly get rid of the purulent and inflammatory diseases.
Price lincomycin, where to buy
Cost Lincomycin in ampoules an average of 40 rubles for 10 vials of 1 ml.
Cost tablets Lincomycin from 60 to 90 rubles per 20 pieces. Buy drug capsules in Ukraine can be an average of 25 UAH. (30 pcs.).
Ointment lincomycin-Akos It can be purchased at the price of 27 rubles.
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