Kaptopres

Description overdue on 11-11-2011

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Combined preparation. In its composition contains an ACE inhibitor and a diuretic. It has hypotensive (captopril), and diuretic (hydrochlorothiazide). Captopril   reduces the production angiotensin   II, which prevents its vasoconstrictor effect and reduces the secretion of aldosterone in the adrenal glands. Reduced preload on the myocardium, the total vascular peripheral resistance, the pressure in the pulmonary circulation, right atrial pressure, blood pressure. Increased exercise tolerance, cardiac volume . Long-term use of the drug captopril reduces the severity of left ventricular hypertrophy (left ventricle), reduced the rate of LV dilatation, preventing the progression of heart failure.

Hydrochlorothiazide   removes from the body potassium . chlorine , Water and sodium   in moderation. Reduction of the sodium ions in the vascular wall reduces sensitivity to vasoconstrictive action, enhanced hypotensive effect of captopril. The maximum level of captopril in the body is noted after 30 minutes. after receiving the pills. Food intake reduces the absorption process components PM. Captopril is available in tablet form.

Indications:

Hypertension.

Contraindications:

Kaptopres not prescribed for pathologists renal and hepatic systems, renal artery stenosis, mitral stenosis, aortic valve, collagen, while pregnancy . gout . hyponatremia . hypovolemia , Primary hyperaldosteronism . hypercalcemia .

Side effect:

Cardiovascular system Excessive decrease in blood pressure, angina . arrhythmia , Palpitations, stroke ischemic type. Respiratory system : bronchospasm , dry cough, laryngitis . sinusitis . bronchitis . rhinitis . The urinary system : Rarely observed renal failure, proteinuria . Metabolism Hyperglycemia, hyperuricemia, hypercalcemia, hypercholesterolemia, hypomagnesemia. Gastrointestinal tract : Diarrheal disorders, taste perception, increased liver enzymes, dry mouth, diarrhea, cholestatic jaundice , Ileus, pancreatitis, hepatitis . Central nervous system Depression, convulsions , Drowsiness, dizziness, blurred vision. Bodies of hematopoiesis: pancytopenia, eosinophilia, leukopenia , Agranulocytosis. Allergies oniholizis , Alopecia.

Mode of application:

The initial dose of the drug is 25 mg Kaptopres that is ½ tablet. Take 1 time a day. The dosage and period of treatment set individually.

Overdose:

It noted a sharp drop in blood pressure, neutropenia , headache, tachycardia , Breach of taste perception, allergies. Severe consequences of an overdose of hydrochlorothiazide due to the action on the nervous system: coma, disruption of water and electrolyte balance (VEB). Requires detoxification therapy ( hemodialysis ), The restoration of VEB, normalization of the central nervous system, cardiovascular system, renal and respiratory systems.

Special instructions:

Kaptopres administered with caution to patients with scleroderma . systemic lupus erythematosus   and other connective tissue diseases. Before applying are encouraged to carry out the correction of water and electrolyte balance. Not allowed concomitant use of potassium supplements, potassium-sparing diuretics in severe lesions of renal system. During treatment, it is recommended a diet low in Na. It is important to remember that Kapropresom therapy can cause false positive reactions in the study urine acetone. When expressed renal lesions of hydrochlorothiazide can lead to azotemia May accumulate components of the drug in the body. In case of violation of water-electrolyte balance, zabolevnaiyah liver diuretics leads to the development hepatic coma . Hydrochlorothiazide increases urea   in the blood that can provoke an aggravation of gout. Kaptopres may cause exacerbation of SLE, reduce the level of thyroglobulin excretion Ca. Requires complete rejection of alcoholic drinks. Kaptopres contraindicated in pregnancy, is not applied in paediatrics. It reduces the speed of psychomotor reactions.

Drug Interactions:

Effect of the drug Kaptopres increase diuretics, antihypertensive drugs, apressin, prazosin,   verapamil , Beta-blockers, methyldopa, clonidine, drugs reserpine, oktadin, calcium channel blockers, nitrates, tranquilizers , Hypnotic drugs, tricyclic antidepressants, alcohol. Preparations of NSAIDs reduce the antihypertensive effect of the drug. Admission amiloride, spironolactone, triamterene, Heparin   It leads to hyperkalemia. Formulations lithium linger in the body, increasing its toxicity. Cytotoxic agents, immunodepressenty, GCS, allopurinol   increase the risk of bone marrow suppression. The drug enhances the effect of biguanide antidiabetic drugs, sulfonylurea derivatives (Manin, glibenclamide , Glipizide, Amarah, glimepiride).