Description overdue on 09/03/2014
- Latin name: Glutargin
- ATC code: A05BA01
- Active substance: Glutamate Arginine (Arginine glutamate)
- Manufacturer: FC LTD "Health" (Ukraine)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Glutargin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
It should be noted that the chemical composition Glutargin depends on the form of the drug.
One Tablet formulation may contain 250 or 750 mg arginine glutamate (active drug).
As part of one milliliter solution Glutargin Intended for infusion contains 40 milligrams of active compound in one vial and the drug - 200 mg.
In one milliliter concentrate for solution It contains 400 milligrams arginine glutamate And in ampoule - 2 grams of drug.
As part of the same Tablets Glutargin Alkoklina contains one gram active compound current, and in one sachet powder intended for solution for subsequent ingestion - 1 gram.
Product form
White color Tablets Glutargin , Containing 250 or 750 milligrams arginine glutamate packed with 10 or 30 pieces shaped blisters, and then packaged in cartons 3, 5, 6 or 1, 2 blisters (respectively) in each.
Glutargin solution for infusion and concentrate the solution is filled into vials of 200 milligrams or 2 grams (respectively) in each.
Tablets and Powder Glutargin Alkoklin for the preparation of the solution is filled into blisters contour 2 or 10 units, as well as special bags for 3 or 6 grams each (respectively). Then tableted medicament placed in cartons in each blister 1, and the powdered compound in bundles of 2, 5 or 10 bags (3 or 6g) each.
Pharmacological action
How Glutargin And Glutargin Alkoklin are gipoammoniemicheskoy group preparations which have hepatoprotective pharmacological properties .
Pharmacodynamics and pharmacokinetics
The active drug compound Glutargin or alkoklin , Part of these preparations is the reaction product glutamic acid and arginine . This compound plays a significant role in neutralizing ammonia Which in turn is highly toxic metabolite, in the human body as a result of interaction nitrogenous substances.
Besides that, Glutargin It assists in the removal of toxic and deadly health compounds from the body. Due to the unique properties of the active substances in the chemical composition of the drug, as the Glutargin And Glutargin Alkoklin It has hepatoprotective and anti-hypoxic and anti-oxidant effects.
Both drugs show membrane stabilizing activity Thereby exerting a positive influence on the hepatocytes Thus maintaining the energy supplying processes occurring in them every second. Glutargin Alkoklin is simply indispensable for alcohol intoxication .
The drug is effectively stimulate decomposition alcohol liver with help monooxygenase system And enhances the production alcohol Ie an enzyme that promotes "recycling" ethanol in humans. The drug speeds up the process of removing metabolites of ethanol and inactivation increases, thus increasing the production succinic acid.
This reduces the influence of alcohol at nervous system person because of the unique properties of neurotransmitter glutamic acid . The drug has no mutagenic, embryotoxic or gonadotoxic effects And do not cause patients immunotoxic or all sorts of allergic reactions .
Indications
Glutargin used to treat:
- hepatitis , Including acute or chronic forms of diseases of various etiologies;
- cirrhosis ;
- hepatic encephalopathy ;
- effects of poisons contained in the composition of plant material, e.g., death cup, as well as pharmaceuticals and chemicals;
- leptospirosis ;
- states precoma or Coma Provoked ammoniemia ;
- alcohol poisoning, including in alcoholic coma and encephalopathy ;
- disorders postintoksikatsionnogo nature By ingestion of large doses of alcohol.
In addition to active drug it is often a part of a complex therapeutic regimen Alcoholism Because it helps to eliminate the consequences of the "hangover" intoxication and extreme intoxication.
Glutargin Alkoklin used for:
- Prevention Alcoholism ;
- treatment of acute alcohol poisoning , and postintoksikatsionnyh disorders.
Contraindications
Both drugs are not recommended during treatment of people under the age of 18, pregnant or breast-feeding women, patients feverish And having renal dysfunction , namely azotovydelitelnoy filtration capacity body. In addition, the drugs are contraindicated in severe psychosis and hyperexcitability.
Side effects
Pretty rare, however, when taking drugs may experience the following side effects:
- discomfort in the gut;
- heaviness in the stomach ;
- nausea .
The above-mentioned side effects of drugs disappear immediately after the cessation of the use of medicines.
Instructions for use Glutargin (method and dosage)
Tablets Glutargin 250 mg. , The instructions for use: 3 times a day for 15 days. The recommended dosage of the drug lump sum equal to 0, 75 grams, which corresponds to the 3rd tablets. The maximum allowable dose of 8 grams per day, or 2 grams at a time. The treatment may be extended to 20 days if medically necessary.
750 mg Tablets . each take three times a day, one at a time for two weeks. If necessary, treatment can be up to three weeks. In the treatment of alcohol poisoning effects take 1, 5 tablets four times a day with intervals of 2, 5 hours. Then another 3 days should take one tablet of the preparation two times a day.
In order to prevent serious consequences and prevention alcohol intoxication patients should take 2, 5 tablets an hour before drinking alcohol.
Solution or Concentrate Glutargin (ampules of 2 grams) designed for intravenous infusion is administered twice a day at an average rate of 70 drops per minute. To prepare the solution contained in ampoules drug compound is mixed with 250 ml. Sodium chloride (isotonic) . Typically, the course of treatment is 5-10 days in average. The maximum recommended daily dosage should not exceed 8 grams.
To prevent hepatotoxic effects alcohol on the body, and also to prevent alcohol intoxication Tablets Glutargin Alkoklina take two pieces of a maximum of two hours prior to the direct consumption of alcoholic beverages. Powder containing active compound active prior to use is dissolved in water and ½ cup also take two hours to direct alcohol.
In the treatment of the consequences alcohol intoxication tablets or powder Glutargin Alkoklina take one piece or sachet (respectively) four times a day at intervals of two and a half hours and then for an additional 3 days - one at a sachet or twice per day. In severe alcohol poisoning the drug is taken in tablet or powder packets twice a day for 20 days.
Overdose
If you exceed the recommended dosages of these drugs may experience symptoms such as headache, vomiting, hypotension, insomnia, reduction Blood Pressure , and atrioventricular (AV) block or allergic reactions . In such cases, you should immediately stop taking the drugs, and then to carry out the symptomatic treatment of patients.
Cooperation
In order to avoid undesired amplification or attenuation efficacy of drugs improve insulin and reduction in blood neurotoxic effects caution should be taken and Glutargin Glutargin Alkoklina conjunction with antiplatelet drugs For example, with Dipyridamole , and Isoniazid, Aminophylline and Vinblastine .
Terms of sale
Buy both drugs at a pharmacy without a prescription can be.
Storage conditions
Both the drug should be stored out of the reach of children, at a temperature not exceeding 25 ° C.
Shelf life
2 years
Cautions
To avoid the negative impact that increasing the level expressed in insulin levels with extreme caution should be used both drugs to patients suffering from endocrine diseases . Both the drug does not affect the patients' ability to drive vehicles, as well as to work with potentially dangerous machinery.
Analogs Glutargin
Enerliv
Laennek
Progepar
Antral
Potassium Orotate
Hepa-Merz
Legalon
Phosphogliv
Galstena
Karsil
Essentiale
The main analogue Glutargin considered Glutargin Alkoklin .
Babies
Both drugs are not used in the treatment of patients under 18 years of age.
During pregnancy and lactation
As of today experts do not have reliable data on the impact of drugs on the development and health of a child, these drugs are not recommended for pregnant women and nursing mothers.
Reviews Glutargin
The bulk of these reviews about Glutargin are positive. Patients say the effectiveness of the tablets Glutargin who do an excellent job with both liver disease And the consequences alcohol intoxication, and poisoning , Including severe. Many have noted the indispensability of drug hangover.
It should be noted that those patients who received Glutargin Alkoklin , Opinions about the drug leaves a good, noting the obvious advantages among the effectiveness of the drug, a small list of side effects and contraindications for use.
Price Glutargin where to buy
The cost of drugs depends primarily on the shape of their release and the region. The average price of tablets Glutargin (packaging, 30 pcs. 250 mg. Each) is 38 UAH. Price Glutargin in Kharkov (packaging, 30 pcs. 250 mg. Each) on average is 33 UAH.
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