Description overdue on 09/19/2014
- Latin name: Ampisid
- ATC code: J01CR04
- Active substance: Ampicillin + Sulbactam (Ampicillin + Sulbactam)
- Manufacturer: Mustafa Nevzat Ilach Sanayi A.Ş. Turkey
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Ampisida (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Pills They include 375 mg sultamicillin And sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate.
Powder for oral suspension It contains 250 mg / 5 ml sultamicillin , Sucrose, acetic anhydride, xanthan gum, giproloza, sodium dihydrogen phosphate, sodium carmellose, flavor "guar".
Powder / m injection comprises sultamicillin in different parts of the mass and accompanying solvent ( lidocaine ).
Powder w / and w / o Injection comprises sultamicillin in different parts of the mass and accompanying solvent (water for injection).
Product form
Medicine Ampisid It is available in several pharmaceutical forms:
- in shape film coated tablets - 375 mg №10 in the package;
- in shape powder for further cooking oral (oral) suspension of - 250 mg / 5 ml. The package 1 vial of 70 ml or 40 ml;
- in shape powder for further preparation of injection solution for intramuscular administration - 250 mg / 500 mg / 1000 mg + 125 mg / 250 mg / 500 mg, respectively. The package 1 vial of powder + solvent;
- in shape powder for further preparation of injection solution for intramuscular and intravenous administration 250 mg / 500 mg / 1000 mg + 125 mg / 250 mg / 500 mg, respectively. The package 1 vial of powder + solvent.
Pharmacological action
Antibacterial.
Pharmacodynamics and pharmacokinetics
Ampisid (Ampisid) is a bactericidal acid- antibiotic with a fairly broad spectrum. The mechanism of action by blocking replication peptidoglycan bacterial cell wall.
One of the active substance preparation contains ampicillin - Semisynthetic antibiotic penicillin Affected by the destruction beta-lactamase.
Another component of the drug - sulbactam Which by itself does not exhibit antibacterial activity, however, it plays an important role in the mechanism of action. Suppressing Beta-lactamase It contributes to effective action on ampicillin-resistant strains that produce beta-lactamase.
Sultamicillin active against gram-negative and most of gram-positive microorganisms.
Not effective against all strains Pseudomonas aeruginosa, staphylococcus strains penitsillinazoprodutsiruyuschim , Most Enterobacteriaceae strains and Klebsiella.
Sultamicillin action on microorganisms which produce a beta-lactamase is less than the effectiveness of ampicillin.
When taken orally, is hydrolyzed sultamicillin providing sulbactam and ampicillin concentration in the blood in a molar ratio of 1: 1.
Cmax ampicillin exceeds 2 times the concentration observed at oral doses equal Ampicillin.
Bioavailability is equal to 80% of the equivalent in / in the dose of ampicillin and sulbactam.
T1 / 2 for sulbactam and ampicillin - 75 minutes and 1 hour, respectively (increases in elderly patients and in patients with severe renal failure ).
50% and 75% of sulbactam ampicillin excreted in the urine in unchanged form.
When injected, it penetrates into most body fluids and tissues (permeability in inflammation in the CSF increases dramatically).
In the blood reaches a sufficiently high concentration of active substances.
T1 / 2 for both active ingredients is 1 hour.
Sulbactam hardly metabolized.
Basically unchanged in 70-80% of the drug is excreted by the kidneys, and the rest 20-30% in the bile, as well as mother's milk.
Indications
Bacterial infectious diseases, which were caused by sensitive sultamicillin pathogens of various localization:
- Infectious diseases of upper respiratory tract (including tonsillitis, otitis media );
- infectious diseases of the respiratory system (including chronic bronchitis, pneumonia, empyema, lung abscess );
- infectious diseases of the genital organs and the urinary tract (including endometritis, pyelitis, cystitis, pyelonephritis, urethritis, prostatitis );
- infectious diseases of soft tissues and skin (including impetigo, erysipelas, re-infected Dermatitis );
- biliary tract infections (including cholangitis, cholecystitis );
- infectious diseases of the joints and bones;
- gastrointestinal infectious diseases (including dysentery, salmonellonositelstvo, salmonellosis );
- from eptichesky endocarditis, gonococcal infection, meningitis, sepsis, scarlet fever, peritonitis.
Also Ampisid antibiotic used to prevent possible complications in the postoperative period and surgical interventions on the pelvic and abdominal cavity.
Contraindications
- period breast-feeding ;
- infectious mononucleosis;
- hypersensitivity.
With caution is prescribed during pregnancy, as well as hepatic and / or renal insufficiency.
Side effects
Gastrointestinal tract:
- loss of appetite;
- nausea;
- diarrhea;
- vomiting;
- increased activity of "liver" transaminases;
- sometimes - pseudomembranous enterocolitis.
Hematopoiesis and hemostasis system:
- thrombocytopenia;
- leukopenia;
- anemia.
Nervous system:
- malaise;
- headache;
- hypersomnia.
Allergic symptoms:
- angioedema;
- hives;
- rhinitis;
- flushing of the skin;
- conjunctivitis;
- arthralgia;
- eosinophilia;
- fever;
- anaphylactic shock.
Others:
- during long-term therapy possible superinfection, which is caused by microorganisms resistant to sultamicillin (candidiasis).
Laboratory findings:
- increase of urea;
- azotemia;
- hypercreatininemia.
Local reactions:
- when administered by intramuscular injection - pain at the injection site;
- when administered intravenously - phlebitis.
Instructions for use Ampisida (method and dosage)
For drug Ampisid owner application provides several methods of delivery of the drug into the body intravenously, orally (oral) and intramuscularly.
The method of application of the drug and the required daily dose determined by the attending physician, depending upon the severity of the pathology, its flow, and localization of the individual characteristics of the patient. Before therapy is required to carry out intradermal trial to determine the characteristic of each patient's sensitivity to the antibiotic, to prevent further allergic reactions.
Typically, the drug inner Ampisid suggestions for 60-120 minutes before the meal, in a daily dose of 375 mg to 750 mg for adult patients of age and at a daily dose of 25 mg to 50 mg per kilogram of body weight for children whose weight does not exceed 30 kg. The daily recommended dose divided into 2 doses.
Treatment with intravenous Ampisida (bolus slowly over 3-5 minutes or as an infusion) administered in clinically severe cases of the disease. A single dose of the drug is dissolved in 100 ml or 200 ml of isotonic solution or a 5-10% glucose solution. The daily dose, depending on the severity of disease can vary from 1500 mg (easy flow) to 12000 mg (in extreme cases). Typically intravenous preparation is for 5-7 days, followed by transfer to intravenous injection. The daily dosage for pediatric patients weighing less than 30 kg, is determined based Ampisid 15 mg per kilogram of body weight (with mild disease).
In accordance with the half life of the drug administration the daily dose is divided into Ampisida 3-4. Another treatment regimen, drug administration is carried out two times per day. The course of therapy generally does not exceed 14 days. It is worth noting that after the disappearance of symptoms and normalization of the general condition, it is advisable to continue taking the drug Ampisid for another 2 days.
For prevention postoperative infections th administered 1500 mg-3000 mg Ampisida, immediately before surgery.
Overdose
Symptoms, which occur when an accidental overdose Ampisidom radically different from the potential side effects of the drug. It should be remembered that beta-lactam antibiotics in high doses can lead to serious violations CNS function , Including the convulsions.
Recommends a symptomatic treatment with gastric lavage and appoint hemodialysis Which is effective for removing ampicillin And for sulbactam .
Cooperation
The drug is incompatible with pharmacologically Ampisid aminoglycosides, protein hydrolysates and blood products.
When an internal reception glucosamine, antacids, laxatives, aminoglycosides And can reduce food intake and / or slow absorption sultamicillin Whereas reception ascorbic acid increases it.
Bacteriostatic drugs ( Chloramphenicol, macrolides, lincosamides, sulfonamides, tetracyclines ) Antagonize (lower efficiency) effect.
Bactericidal antibiotics (including cephalosporins, aminoglycosides, cycloserine, rifampicin, vancomycin ) Cause a synergistic (increase efficiency) action.
Diuretic drugs, NSAIDs, Phenylbutazone, allopurinol and other drugs that reduce tubular secretion , Increases the amount of ampicillin in the plasma.
Receiving Allopurinol It raises the possibility of a rash on the skin.
Sultamicillin It inhibits the intestinal microflora, reduces prothrombin index and replication Vitamin K Thereby increasing the efficiency of indirect anticoagulants.
Ampisid reduces the effect of oral contraceptives, ethinyl estradiol, and drugs the metabolism of which the body is formed of PABA.
Terms of sale
Prescription.
Storage conditions
List B. In a dry, dark place at a temperature below 25 ° C.
Shelf life
To oral dosage forms - 24 months.
To injectables - 36 months.
Cautions
During the course of therapy with Ampisida necessary to carry out continuous monitoring of renal and hepatic function, and the function of the blood.
Patients with a history is an indication of increased susceptibility to antibiotics penicillin Perhaps a manifestation of cross-allergic reactions cephalosporin antibiotics.
During the treatment of patients with sepsis, there is a risk of Jarisch-Herxheimer reaction (reaction bacteriolysis).
Due to the growth of insensitive sultamicillin microflora may form superinfection, that is an indication for the revision of antibiotic treatment .
When treating a patient suffering from gonorrhea, It is suspected syphilitic lesions It is necessary to appoint a study in the dark field, before applying Ampisida, followed by serological tests every 30 days for at least 4 months.
Analogs Ampisida
Augmentin
Amoxil 625 K
Flemoklav Soljutab
Sultasin
Amoxiclav
Analogs are presented preparation of a drug of pharmacological and have similar mechanisms of action. Pharmacological industry produces a lot of unique drug Ampisid (Ampisid), the most famous of which are:
- Amoxicillin;
- Amoxiclav;
- Augmentin;
- Flemoklav;
- Oskampitsin;
- Medoklav;
- Sulbatsin etc.
Babies
It is used for the treatment of pediatric patients at recommended doses.
With alcohol
Do not drink beverages containing alcohol, against the background of therapy with Ampisid.
Ampisid during pregnancy and lactation
With pregnancy used with caution, after consultation of the attending physician and comprehensive assessment of the risk to the fetus.
It is better to give up breast-feeding during treatment with Ampisida.
Reviews Ampiside
Reviews Ampiside talk about unconditional effectiveness of the drug in the treatment of infectious diseases caused by microorganisms sensitive to it. Describe the various side effects of the drug that are transmitted and often poorly expressed. With proper selection of treatment regimens and in the absence of contraindications drug Ampisid shows good results.
Price Ampisida where to buy
Pharmacies Russian price Ampisida tablets 375 mg №10 ranges from 250 to 350 rubles.
Cost suspension for oral 40 ml of an average of 230 rubles.
Price injectable form of the drug It depends on the dosage and number of vials.
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