Description overdue on 08/11/2014
- Latin name: Driptane
- ATC code: G04BD04
- Active substance: Oxybutynin (Oxybutynin)
- Manufacturer: Rezin Fontaine, France
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Driptan (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
As part of one tablet:
- oxybutynin hydrochloride - 5 mg;
- Anhydrous lactose ;
- MCC ;
- calcium stearate .
Product form
The drug is released in the form of circular tablets. White color. The tablets have a lenticular shape and scored on one side. The medicine is packed in blisters in cartons of 30 or 60 tablets.
Pharmacological action
Spasmolytic .
Pharmacodynamics and pharmacokinetics
Oksibutin It has a direct antispasmodic effect on the smooth muscle fibers detrusor . The substance blocks the effect of acetylcholine on Mr. holinoblokatory bladder. Next detruzor It relaxes its scope, on the contrary, increased frequency of spontaneous urination is reduced.
After rapid and substantially complete absorption in GI , The active substance reaches the systemic circulation. An hour later, the concentration is maximal. Reducing the concentration curve - the exhibitor, the half-life of approximately 3-4 hours.
Within 8 days of receiving a systematic means reached its equilibrium concentration in plasma. If elderly patients lead an active lifestyle, the drug does not accumulate in tissues and organs. However, in immunocompromised patients are lengthened pharmacokinetic indicators. Active ingredient inclined metabolized in the liver, and metabolites also exert blocking effects on m-cholinergic receptors . Withdrawal of the drug through the kidneys as metabolites.
Indications
The drug is prescribed:
- treatment Incontinence , At various neurogenic disorders ;
- at Idiopathic dysfunction detrusor .
It is also an indication for the use of funds is incontinence ( nocturnal enuresis ) In children older than 5 years.
Contraindications
The drug is contraindicated:
- at angle-closure glaucoma ;
- at allergies into its components;
- intestinal atony ;
- at ulcerative colitis ;
- obstructive uropathy ;
- lactating women;
- Children up to 5 years;
- at obstruction of the gastrointestinal tract ;
- during expansion colon ;
- at myasthenia ;
- a tendency to bleed or if available.
Side effects
The most common side effects are manifested:
- diarrhea , Nausea, abdominal pain and discomfort abdominal . constipation ;
- mydriasis , problems with accommodation of ;
- cardiac arrhythmia , Reduction libido males impotence ;
- allergy . headache . insomnia . dizziness , Weakness, increasing Intraocular pressure .
Instructions for use Driptan (method and dosage)
Orally. A tablet may be split or crumble.
Driptan, instructions for use for adults
The recommended daily dose is 10-15 mg, divided into 2-3 receptions. The maximum daily dose (20 mg) may be appointed only after consultation with the doctor, and at normal tolerance of adverse reactions.
For older people need a dose adjustment. How rule, prescribe on 2, 5 mg, 2 times per day. The maximum daily dose - 10 mg.
For children from five years are usually given 5 mg per day, divided into 2 doses. The dosage can be increased up to 5 mg three times a day, after consultation with a specialist. For the treatment of nocturnal enuresis last tablet should drink immediately before bedtime.
Overdose
Symptoms of overdose are: excitement of the nervous system, tides , Reduction BP . paralysis . coma , Respiratory distress, dizziness.
Treatment: gastric lavage, symptomatic therapy, mechanical ventilation, the use of neostigmine . diazepam or propranolol . If there is a delay of urine, is shown catheterization bladder.
Cooperation
Effect of the drug may reduce other Mr. holinomimetiki .
Terms of sale
Prescription.
Storage conditions
Keep out of the reach of children. Store in a cool place, in original packaging.
Shelf life
3 years.
Cautions
Be particularly careful in the treatment of oxybutynin children from 5 years in connection with increase probability of occurrence of of adverse reactions, especially wasps side of nervous system.
With caution in elderly patients with autonomic neuropathy , Diseases GI , Kidney or liver disease, porphyria .
It is not recommended to prescribe a drug for pregnant women.
It should refrain from driving or other mechanisms that require high concentration of attention, while taking the drug.
Analogs Driptan
Vesicare
Urotol
Spazmeks
Analogues of: Sibutin, Vesicare, Drim-Apo, Detruzitol, Spazmeks, Uroholum, Zevesin, Urotol .
Reviews Driptane
Reviews on the different forums. Some drugs help, urge to urinate, especially at night, is getting smaller. However, many complain of allergies, headaches and other side effects. According to them the medicine inefficiently.
Reviews Driptane children ambiguous. Doctors often prescribe Driptan at night enuresis and incontinence in children. But due to the fact that the side effects in children appear more and more pronounced, parents give the drug cease their children. Many believe that the drug is not suitable for children, replace it with peers.
Price Driptan
The cost of 30 tablets means approximately 524 rubles.
Price Driptan in Ukraine - 160 hryvnia for 30 tablets of 5 mg.
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