Description overdue on 07/07/2014
- Latin name: Gynepriston
- ATC code: G03XB01
- Active substance: Mifepristone (Mifepristone)
- Manufacturer: JSC "Obninsk chemical and pharmaceutical company", Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The composition of each tablet is included 0, 01 g of the active substance - mifepristone . Also added excipients: 0, 0746 g microcellulose 0, 0045 g of sodium carboxymethyl starch and 0 0009 g calcium stearate .
Product form
Available in the form of tablets spigot of a light yellow color, which weigh 0 '01 Each tablet alone or two tablets are placed together in blisters or polymer bank. Each blisters or polymer bank is located in the stack of cardboard.
Pharmacological action
It has antigestagens action .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Ginepriston is a synthetic steroid antigestagens drug - it has the ability to block the action progesterone at the receptor level.
Its effect stimulates the increase in contractile ability myometrium , Promotes the release of substances that increase the sensitivity of the myometrium to certain types of hormones. Depending on in which phase of the menstrual cycle was adopted drug, it can cause inhibition Ovulation , To promote change endometrial And prevent Implantation already fertilized egg.
Pharmacokinetics
The maximum concentration in blood after administration of the dose of 600 mg is achieved after one-time 1-1, 5:00.
The absolute bioavailability Ginepristona is 69%.
98% entered the blood drug binds to plasma proteins, in particular, albumin .
Withdrawal from the body takes place unevenly. First, the concentration is halved slowly (72 hours), and then more quickly. The half-life is then equal to 18 hours.
Indications
Ginepriston to interrupt pregnancy used as postcoital (emergency) contraception Ie in cases where sexual intercourse was unprotected, or if used when it turned out to be an unreliable method of contraception.
Contraindications
Contraindications include:
- a history indication of increased sensitivity to mifepristone ;
- adrenal insufficiency and long-term therapy glucocorticosteroids ;
- acute and chronic renal and / or liver insufficiency;
- severe extragenital .
Precautions to be taken in the use of Ginepristona should:
- various violations hemostasis (including disorders caused by previous treatment anticoagulants );
- Chronic obstructive ivnyh lung diseases (eg, bronchial asthma );
- heavy hypertension ;
- cardiac arrhythmias;
- Heart Failure .
Side effects
Ginepristona side effects may be due to the occurrence of discomfort in the lower abdomen, weakness, headache, nausea, vomiting . dizziness . hives . Hyperthermia , Bleeding from the genital tract, may appear menstrual irregularities .
Instructions for use (method and dosage)
Take 1 tablet into no later than 72 hours after unprotected intercourse. One can not take food for 2 hours before and after taking the drug.
Ginepriston used in any of the phases of the menstrual cycle.
Overdose
In the case of reception Ginepristona in doses not to exceed 2 g unlikely undesirable reactions. When you receive a high dose of the drug can disrupt adrenal glands develop their failure .
Cooperation
Concomitant use with NSAIDs .
Terms of sale
Sold by prescription.
Storage conditions
Keep in a dark, dry place. The ambient temperature must not exceed 30 ° C. A place where you store the tablets should be available for children.
Shelf life
3 years.
Cautions
It is undesirable to use on a regular basis as a means of permanent, routine contraception.
Analogs
Esmiya
Zhenale
Mifegin
Miropriston
Mifepristone
Penkrofton
Ginepristona analogs are drugs such as: Gynestril administration, Miropriston, Mifegin, Mifotab, Mtpill, Postinor, eskapel, Pharmatex and several others.
Is it better or Postinor Ginepriston?
Ginepriston effect on a woman's body is softer than Postinor, and has a user-friendly version of the application - one tablet once, instead of two with an interval between doses in 12 hours. In addition, it is no less effective. Doctors recommend Ginepriston as a more secure method.
Ginepriston or eskapel - which is better?
According to responses of women who have used these drugs, Ginepriston is often more effective than eskapel. And the manifestation of the side effects are much smaller.
During pregnancy and lactation
Contraindicated during reception pregnancy .
Lactation you need two weeks to stop if Ginepriston was adopted.
Reviews Ginepristone
Opinions about this drug, as a means for abortion is already a lot - it reviews the doctors and the people who use the drug.
Gynaecologists Reviews of Ginepristone in most cases positive, because it acts softer than most of these tablets. Of course, this applies to those cases where tablets are used in accordance with the instructions on Ginepriston. Yet, among the patients a lot of complaints of side effects.
Price Ginepristona where to buy
Price Ginepristona the pharmacy - from 165 rubles.
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