Description overdue on 09/21/2014
- Latin name: Livodexa
- ATC code: A05AA02
- Active substance: Ursodeoxycholic acid (Ursodeoxycholic acid)
- Manufacturer: Sun Pharmaceutical Industries Ltd., India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications for use of the drug
- Contraindications
- Cautions
- Side effects
- Livodeksa, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The medicine contains an active substance - UDCA 150 or 300 mg, and auxiliary ingredients: lactose, starch, microcrystalline cellulose, sodium carboxymethyl starch, sodium lauryl sulfate, magnesium stearate, colloidal silicon dioxide, talc, povidone and purified.
Coated tablet consists of hypromellose, macrogol 6000, titanium dioxide, iron oxide yellow and red.
Product form
Produced Livodeksa in round tablets coated with a red-brown shell membrane. The packaging proposed by 10, 50 or 100 pieces.
Pharmacological action
The drug has choleretic, cholelitolitic, lipid-lowering, cholesterol-lowering and immunomodulatory action.
Pharmacodynamics and pharmacokinetics
The hepatoprotector It causes stabilization of membranes hepatocyte and cholangiocytes By providing a direct cytoprotective effect. Acting on bile acids, hydrophobic drug reduces the toxic acids. Malabsorption cholesterol in the intestines and other biochemical effects is due to the cholesterol-lowering effect. Thus inhibited cell death, which cause toxic bile acids.
Ursodeoxycholic acid It reduces the ability of gastric reflyuktata damage to cell membranes at biliary reflux esophagitis and reflux gastritis It reduces the level of cholesterol in the bile, increases its solubility, reduces bile lithogenic index, and so forth.
Immunomodulatory effect caused inhibition of the expression of HLA-antigens membranes cholangiocytes and hepatocyte It normalizes killer activity lymphocytes . This delayed development of fibrosis in patients with primary biliary cirrhosis, alcoholic steatohepatitis and cystic fibrosis It decreases the likelihood of developing varicose veins in the esophagus.
Absorption ursodeoxycholic acid It derived from jejunum by passive diffusion, but ileum - active transport. Distribution of the active ingredient has a high degree of binding to plasma proteins in the composition. Determined that ursodeoxycholic acid able to penetrate the placental barrier.
Inside the body the active substance falls into glycine and taurine conjugates are secreted into bile. Approximately 50-70% of the metabolites is derived as part of bile.
Other penetrates into the colon, bacterial being split into components with generation of lithocholic acid. This material is partially absorbed from the gastrointestinal tract, then biotransformed in the liver sulfolitoholiltaurinovy sulfolitoholilglitsinovy conjugates and then excreted from the body.
Indications for use of the drug
Livodeksu appoint:
- in primary biliary cirrhosis, if there are no signs of decompensation;
- to dissolve small or medium cholesterol stones, with a functioning gall bladder;
- at biliary reflux esophagitis and reflux gastritis ;
- alcoholic liver disease;
- Chronic hepatitis various origins;
- nonalcoholic steatohepatitis;
- biliary dyskinesia
- primary sclerosing cholangitis ;
- cystic fibrosis or cystic fibrosis .
Contraindications
Do not use Livodeksu patients suffering from:
- gallstones;
- non-functioning gall bladder;
- sharp inflammation of the gallbladder . bowel and bile duct ;
- cirrhosis of the liver decompensated;
- expressed impaired renal function . liver and pancreas ;
- lactose intolerance , Lactase deficiency, glucose-galactose malabsorption;
- Individual hypersensitivity to its components.
The drug is also prohibited in children up to 3 years. Be wary appoint Livodeksu young patients 3-4 years, as they find it difficult to swallow pills.
Cautions
Successful dissolution of stones provided by their pure cholesterol composition, size 15-20 mm. This fullness of the gall bladder must not be more than half, and the bile duct must maintain their full function.
During the entire treatment is necessary to monitor the activity of liver transaminases, alkaline phosphatase, GGT and concentration bilirubin . When the increased rates persist, the drug immediately overturned.
Early treatment cholecystography held every 4 weeks, and then every 3 months. Monitoring the effectiveness of therapy is performed every six months with the help of ultrasound. When calculi are dissolved completely, the treatment should be continued another 3 months to completely dissolve the remnants of small-sized stones.
In cases where long-term treatment, for example 6-12 months is failed, it should not expect its effectiveness.
If the treatment is found nevizualizatsiya gallbladder - this indicates that the concretions is completely dissolved and treatment to finish.
Calcification of gallstones, variations in the contractile activity of the gall bladder, and frequent bouts of biliary colic require discontinuation of treatment.
Side effects
When treating Livodeksoy may occur disorders of the digestive system in the form of calcination gallstones, increased activity of hepatic enzymes, nausea, diarrhea, abdominal pain. The therapeutic process is of primary biliary cirrhosis is often accompanied by transient decompensation cirrhosis Usually passes after drug withdrawal.
Livodeksa, instructions for use (method and dosage)
Tablets Livodeksa Inside, plenty of drinking water.
For the treatment of each type of violations for readings, set the appropriate dosage and duration of therapy. For example, to dissolve cholesterol gallstones set the daily dose of 10 mg per kg body weight. Tablets are recommended to take in the evening. Duration of treatment an average of 6-12 months.
During the re-emergence of preventing stones treatment does not stop even after the dissolution of stones and lasts a couple of months.
According to the instruction on Livodeksu 300 mg and 150 mg, the calculation of the daily dosage depends on the patient's weight and the recommended dose of the drug per kg of the patient.
Overdose
Cases of overdose Livodeksoy not installed.
Cooperation
Simultaneous use and Livodeksy antacids Which contain ion exchange resin and aluminum, can cause malabsorption ursodeoxycholic acid .
Combination with hypolipidemic drugs, estrogens, neomycin or progestins increases the saturation of bile cholesterol and often reduces the ability of ursodeoxycholic acid to the dissolution of cholesterol gallstones.
This can enhance the absorption of the drug cyclosporine from the gastrointestinal tract, thus requiring concentration monitoring cyclosporine in the blood, and if necessary - to adjust the dosing regimen.
Terms of sale
The drug prescription.
Storage conditions
Livodeksu should be stored in a dark, dry place, protected from children.
Shelf life
2 years.
Analogs Livodeksy
Urdoksa
Ursosan
Ursol
Ursofalk
Main counterparts Livodeksy - a drug Ursosan, Ursofalk, Ursohol, Choludexan, Ukrliv, Ursodeks, Urdoksa and Ursolizin.
Levodeksa or Ursosan - which is better?
Unambiguously answer this question it difficult even experienced professionals. The fact that there may be such cases when you first need to soothe inflammation, and then assign cholagogue drugs. This clarifies that Ursosan It has not sufficiently pronounced choleretic effect, such as Levodeksa.
Therefore, treatment should be administered by the attending physician, as is often recommended complementary therapy enzymes - Panngrolom, pancreatin panzinorm, mezim or Creon .
Alcohol
During treatment with this drug is strictly prohibited the use of alcohol, as this has a negative impact on the internal organs and significantly reduces the effectiveness of therapy.
Reviews Livodekse
As a rule, the discussion of the drug found on specialized sites. However, users often share information concerning the characteristics of the reception and ask different questions.
For example, some patients doubt the assignment is correct dosage. The fact is that in the instructions indicated that the tablets should drink at night, and your doctor has prescribed 2 tablets. However, as shown Livodekse reviews about 300 mg, but this dose is one tablet, and if the drug is 150 mg, respectively, then you need to drink 2 tablets in the evening.
In addition, there are messages when treatment with other drugs because of the lack of effectiveness was changed to welcome Livodeksy.
Patients undergoing treatment must understand that taking these pills alone will not help in the full restoration of the liver or gall bladder cleansing stones. Usually conducted comprehensive therapy in combination with other drugs and medical procedures. Only such an approach will allow the state to fully optimize the human digestive system.
Also, an additional should observe careful diet.
Price Livodeksy where to buy
Buy in Moscow Livodeksa tablet of 150 mg in the amount of 50 pieces can be for 251-270 rubles.
Price Livodeksy 300 mg per 50 pieces varies between 426-460 rubles.
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