Description overdue on 26/11/2014
- Latin name: Lincomycin hydrochloride
- ATC code: J01FF02
- Active substance: Lincomycin (Lincomycin)
- Manufacturer: Moshimfarmpreparaty them. Semashko JSC (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
As part of the active substance has an antibiotic linkomitsin and optional ingredients: sodium hydroxide, disodium edetate and water.
Product form
Lincomycin hydrochloride is available as a solution for injection. This colorless liquid with a specific smell gentle, clear or having a light yellowish tint. The vials with the solution packed in cardboard boxes of 5 or 10 pieces.
Pharmacological action
Lincomycin hydrochloride is antibiotic from the group of lincosamides. When using therapeutic doses of the drug it has a bacteriostatic effect on the body. The use of higher concentrations of the active ingredient provides a bactericidal effect. The antibiotic inhibits protein synthesis in cells of pathogenic microorganisms. Basically the active ingredient exhibits activity against Gram-positive bacteria. Resist lincomycin have largely gram-negative bacteria, viruses, fungi, protozoa. Resistance is produced relatively slowly.
There microflora cross resistance to clindamycin, lincomycin, as well as other antibacterial agents, which are a group of lincosamides.
Pharmacokinetics and pharmacodynamics
The active substance is well absorbed in the intestine, the highest concentration in the blood observed after 0, 5-1 h after administration intramuscularly. Blood proteins bind 72%. Penetrate the placenta and is determined in breast milk. Poorly penetrates the blood-brain barrier. Part of the substance is metabolized in the liver. Its half-life time is about 5 hours. Because the body is displayed in unchanged form and metabolites.
Excreted eliminated via the kidneys, as well as the feces and bile. Following intramuscular administration of a therapeutic blood concentration of lincomycin is kept for 17-20 hours if the drug is administered intravenously - then for 14 hours.
Indications
Application Linkomitsina hydrochloride is indicated for such diseases:
- septic processes (the presence of pathological microorganisms in the blood);
- osteomyelitis (inflammation of bone and bone marrow);
- staphylococcal infections;
- disease infectious-inflammatory, which provoked the pathogens exhibiting sensitivity to lincomycin.
Contraindications
Do not take at Linkomitsina hydrochloride high sensitivity to lincomycin and clindamycin. The drug is not prescribed to people who have observed severe impairment of renal or hepatic function. You can not assign pregnant women during lactation, children of early infancy.
Side effects
In the treatment tool may be a manifestation of side effects:
- Digestive System : diarrhea , Vomiting, nausea, abdominal pain, stomatitis, glossitis.
- Hematopoietic system Neutropenia, leukopenia, reversible thrombocytopenia.
- Allergic symptoms : dermatitis . hives . anaphylactic shock . angioedema .
- Candidiasis .
If a drug is administered intravenously, as a local reaction may occur phlebitis .
In the case of rapid intravenous administration may decrease the patient's blood pressure, symptoms of general weakness and dizziness, muscle relaxation skeleton.
Prolonged treatment with high doses of agents can lead to the manifestation pseudomembranous colitis .
Instructions for use (method and dosage)
If the patient was appointed Linkomitsina hydrochloride, instructions for use in the treatment process must be observed.
Instructions on Linkomitsina hydrochloride capsules allows for intravenous and intramuscular administration of the agent.
In appointing the drug intramuscularly adult patients receive daily 600 mg, administration is carried out 1-2 times.
Intravenous drip administration is practiced, with 600 mg of agent is dissolved in 250 ml of glucose or isotonic sodium chloride solution, administration can be performed 2-3 times per day.
Children who are already 1 month old, in the development of serious infectious diseases appointed intramuscular means, the dosage is determined as follows: 1 kg of body weight of 10 mg means. The introduction of a drug every 12 hours. Perhaps intravenous administration, a dose in this case is 10-20 mg / kg per day.
Overdose
If an overdose Linkomitsina hydrochloride, can manifest those symptoms described as side effects from the digestive system - diarrhea, nausea, vomiting. If it is a rapid introduction of undiluted drug, there is a possibility of cardiac arrest. No specific antidote, symptomatic treatment.
Cooperation
If carried out simultaneously with the treatment agent cephalosporins . penicillins . chloramphenicol . erythromycin , There may be an anti-microbial effect of antagonism.
Simultaneous treatment with aminoglycosides can cause synergistic effect.
If at one time accepted Linkomitsina hydrochloride and drugs used for anesthesia or muscle relaxants inhalation peripheral action may increase neuromuscular blockade, may develop apnea .
In simultaneous treatment antidiarrheals marked decrease in the effect of lincomycin.
The tool is not compatible with barbiturates . ampicillin . calcium gluconate . Heparin . theophylline . Magnesium sulfate .
At the same syringe or dropper can not be combined Linkomitsina hydrochloride and Novobiocin and Kanamycin .
Terms of sale
An antibiotic sold in pharmacies by prescription.
Storage conditions
It is necessary to keep away from children, store in the dark at ambient temperature not exceeding 25 ° C.
Shelf life
Shelf life means 3 years.
Cautions
If the patient has irregularities in the liver, kidney, reduce or increase the dosage of the period between the introduction of the drug. If the product is used long period, you need to regularly monitor liver function, kidney and blood laboratory parameters.
Carefully prescribed drug for the treatment of people with a penchant for allergy patients colitis . asthma As well as those with a history of gastrointestinal disease.
If a patient develops pseudomembranous colitis , You need to stop taking the drug.
Analogs
Lincomycin
Clindamycin
Similar effects have drugs: Lincomycin . Lincomycin-Health . Clindamycin . Clindamycin Norton . Dalatsin C and etc.
Babies
It can be used when indicated for the treatment of children aged 1 month. Applicable only for a specialist appointment.
During pregnancy and lactation
Because lincomycin is able to penetrate through the placental barrier, and it is excreted in breast milk, it should not be used to treat pregnant women nursing mothers .
Reviews
Online people leave most of the positive reviews about this drug. In particular, positively evaluated the use Linkomitsina hydrochloride in dentistry, infectious diseases with severe. It is noted that the antibiotic is very effective in eliminating the symptoms and speeds up the healing process.
Price, where to buy
The average price Linkomitsina hydrochloride capsules is 35 rubles per pack of 10 vials.
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