Description overdue on 11/19/2014
- Latin name: Trombovazim
- ATC code: B01AD
- Active substance: Trombovazim (Trombovazim)
- Manufacturer: Siberian Center for Pharmacology and Biotechnology (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Trombovazima (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
Tablets and capsules of this drug contain, as active substance Trombovazim .
Additional components in both forms of the drug - potato starch and sodium chloride .
The capsule shell comprises: azorubin, titanium dioxide, patent blue V and gelatin.
Product form
This drug is found in the form of a freeze-dried product for the preparation of the infusion solution and the semi-finished product. But the most common form of release - capsules and tablets.
Pharmacological action
The drug acts as a thrombolytic . cardioprotective and anti-inflammatory means.
Pharmacodynamics and pharmacokinetics
The drug destroys fibrin strands , Which are incorporated in the main frame of the thrombus. Driving antiinflammatory the action is connected with exposure to oxidative function tissue macrophages and blood neutrophils . Cardioprotective action related to the normalization of blood supply infarction .
The drug is slightly toxic. It does not reduce the content Platelet and it has no effect on the clotting time and bleeding time.
Bioavailability the drug is 20%. It absorbed throughout the small intestine. The maximum concentration is achieved after 5 hours.
Half-life time - 12 minutes. If disrupted kidney, it may increase. After kidney appears unchanged to 80% of the drug while maintaining the specific activity. About 20% is split in the liver, without causing toxic effects.
Indications
The drug is used as a tool to help in treatment chronic venous insufficiency .
Contraindications
The drug should not be used when:
- hypersensitivity to its components;
- breast-feeding ;
- pregnancy ;
- exacerbation gastric ulcer and duodenal ulcer ;
- childhood.
With care, he was appointed to the case, polyvalent allergy , Increased likelihood of bleeding from esophageal varices, remission gastric ulcer and duodenal ulcer , Chronic obstructive pulmonary disease, urolithiasis .
Side effects
As an unwanted side effects may occur allergies , and dyspeptic symptoms (in rare cases). In addition, perhaps a temporary feeling of fullness in the lower extremities.
Instructions for use Trombovazima (method and dosage)
Those who appointed Trombovazim, instruction on the application reports that need to take it inside, 30-40 minutes before meals. Assign 800-1600 IU a day. This dosage is divided into two steps.
Instructions for use Trombovazima indicates that the maximum daily dose - 2000 IU. The treatment time is 20 days. If treatment is not effective, it is necessary to see a specialist. Carrying out of re-treatment on doctor's advice.
Overdose
Overdose cases are not fixed.
Cooperation
Heparin . acetylsalicylic acid and Dipyridamole increase antithrombotic action, without increasing the risk of bleeding. Combination with tetracycline antibiotics enhances the effect of fibrinolitikov . If it is necessary to simultaneously receive medications in which the divalent metal salts are present, this may lead to reduced activity enzymes So it is recommended to do some interval (at least 40 minutes).
Terms of sale
This tool is available in pharmacies by prescription.
Storage conditions
Keep the medication you need in a dry and dark place. Optimum temperature - 25 ° C.
Shelf life
Store this medication should be no longer than two years.
Analogs
Distreptaza
Streptokinase
Manufacturers claim that the composition of Trombovazima analogues do not exist. With its creation, used cutting-edge nuclear physics and electron-beam method of immobilization. Biologically active substances are converted by radiation-activated polymer. Active component of the drug is represented by an enzyme proteinase , Which is complemented by an active polymer protecting it from the effects of the immune system.
Analogs of the preparation of the structural group did not differ a complex action. However, not only destroys Trombovazim blood clots But also reduces the likelihood of new thrombotic events in the vessels of the lower extremities. This drug does not increase the risk of bleeding and has no serious side effects. It is allowed to use a wider group of patients.
Reviews Trombovazime
Reviews Trombovazime forums mostly positive. Patients say bystrodeystvennost and effectiveness of this tool.
Price Trombovazima where to buy
Price Trombovazima considered high enough. You can buy it with a prescription in many pharmacies Russian Federation. Price Trombovazima average can be from 1100 to 1500 rubles.
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