Description overdue on 09/20/2014
- Latin name: Prevenar and Prevenar 13
- ATC code: J07AL02
- Active substance: Polysaccharides several serotypes and the carrier protein CRM197.
- Manufacturer: Prevenar - Wyet Pharmaceutical Division of Wyeth Holdings Corporation, USA Prevenar 13 - Farm Petrovax NMC Ltd, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Immunologically effective
- Indications
- Contraindications
- Side effects
- Overdose
- Cooperation
- Cautions
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Reviews
- Price, where to buy
Composition
The composition contains Prevenar pneumococcal conjugates, i.e. polysaccharides serotypes: 4, 6B, 9V, 14, 18C, 19F, 23F and a carrier protein CRM197.
The vaccine Prevenar 13 includes the seven serotypes shared Prevenar, and the carrier protein CRM197.
In general, this preparation includes capsular polysaccharides of 13 serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, individually conjugated to diphtheria protein CRM₁₉₇ and adsorbed on aluminum phosphate .
Auxiliary components: aluminum phosphate, succinic acid, sodium chloride, polysorbate, and water for injection.
Product form
Available in the form of a suspension of the vaccine white intended for the / m, homogeneous. Perhaps the formation of a cloudy white precipitate. The drug is placed in a disposable syringe, 1 or 5 pieces per pack.
Pharmacological action
A vaccine for the prevention of pneumococcal infections.
Pharmacodynamics and pharmacokinetics
The vaccines for the prevention of pneumococcal infections contains active substances which are pneumococcal polysaccharides derived from grampolaugitionah bacteria Streptococcus pneumoniae Conjugated to diphtheria CRM197 carrier protein, and adsorbed on aluminum phosphate .
With the introduction of the drug begins to develop antibodies to capsular polysaccharides of Streptococcus pneumoniae serotypes few that allows to provide specific protection of the human body from infections they cause.
Immunologically effective
The use of the vaccine for children from 2 months allows to generate a protective immune response after primary vaccination and revaccination. Introduction 3-dose primary vaccination, followed by subsequent booster contributes to a significant upsurge in the level of antibodies. The drug induces the production of antibodies to the functional components of the vaccine serotypes.
In young patients 2-5 years of age children antibodies to serotypes of the vaccine after a single application form. This immune response is almost equal to a survey of children who received the primary series Immunization .
In addition, the vaccine Prevenar 13 is entered for the prevention of infectious diseases, pneumonia and acute otitis media.
Comprehensive identity of these vaccines for safety and immunogenicity profile and allows you to switch to Prevenar Prevenar 13 at almost any stage of vaccination. This 6 additional serotypes only strengthen protection against IPD.
Indications
This vaccine is designed to prevent diseases that cause Streptococcus pneumoniae serotypes included in the product, as well as:
- sepsis;
- meningitis;
- pneumonia;
- bacteraemia and acute otitis media.
Contraindications
Not recommended to spend bacterination when:
- hypersensitivity to the components of the vaccine and diphtheria toxoid;
- acute infectious and non-communicable diseases;
- exacerbations of chronic diseases.
Side effects
Vaccination Prevenar or Prevenar 13 may lead to the development of general and local reactions: redness, swelling, or tenderness at the injection site compaction, hyperthermia more than 38 ° C, irritability, drowsiness, sleep problems.
Also available violation activities hematopoietic, lymphatic, immune and nervous systems and GI : Regional lymphadenopathy, hypersensitivity reactions, convulsions, vomiting, diarrhea, the loss of of appetite and so on.
Instructions for use Prevenar (method and dosage)
The vaccine is designed strictly for intramuscular injection in the anterolateral area of the thigh on the - kids up to 2 years, and in the deltoid muscle of the arm, for example, for children from 2 years old. A single dose of 0, 5 ml.
Before the introduction of the syringe with the vaccine carefully shaken until a homogeneous suspension. Prohibited use of the drug with the foreign particles or change the color.
According to the instruction on the Prevenar 13 and Prevenar, these vaccines are not suitable for intravenous administration.
For children of different age from 2 months up to 5 years are installed certain schemes vaccination Prevenar.
At the age of 2-6 months, a series of 3-fold primary vaccination, at intervals of not less than one month. It is also possible to carry out two-fold primary vaccination with an interval of two months. Perhaps the first dose at 2 months of life. Revaccination is performed once at the age of 11-15 months. This scheme is suitable for individual immunization of children against pneumococcal disease.
If you had not been vaccinated before 6 months of life, it is permitted to use the following schemes:
- Age 7-11 months - carry a 2-fold vaccination at intervals of 1 month. Single-entry revaccination on the 2-th year of life.
- 12-23 months - 2-fold vaccination at intervals of 2 months.
- 2-5 years - once.
When first is introduced Prevenar, then in the future is allowed to use of Prevenar 13. However, vaccination of Prevenar 13 may end with Only with this drug. If you had to increase the interval between injections of a vaccine, the introduction of additional doses are required.
Overdose
Cases of overdose Prevenar unlikely because the vaccine is produced in the syringe, which contains one dose.
Cooperation
It is allowed introduction of of Prevenar simultaneously with the other vaccines, which are included in The National calendar of preventive vaccinations, except for of BCG. According to the agreed immunization schedule can be combined with the hexavalent vaccine Infanrix or vaccination against Hib. This injection must be made in various areas of the body.
Cautions
Prevenar is not used for adult patients.
It is recommended to postpone the introduction, if you have an acute illness, followed by both moderate and severe hyperthermia. To avoid the development of any reactions after vaccination for 30 minutes, the baby must be under the control of a specialist. The rest of the time, being at home, observe the general condition of the child's parents should be.
It was found that the benefits of vaktsinatsinirovaniya this group of patients is highest, so do not give up on it, or postpone. However, we must remember that Prevenar will not protect against serotypes of Streptococcus pneumoniae, are not available in its composition and micro-organisms that cause invasive disease other.
Prevenar vaccination is not administered to children suffering from thrombocytopenia and other disorders associated with blood clotting. These patients are not prescribed intramuscular injections. Exceptions are cases where the potential benefits of vaccination far outweigh the risk, which leads to the introduction of the vaccine.
Availability disorders immunoreactivity due immunosuppressive treatment of HIV infection and so on, may reduce the formation of antibodies in response to vaccination. In general, the decision to vaccinate children belonging to different high-risk groups, it is recommended to take individually.
Producing Prevenar ready to use the syringe, so it is not recommended to put the contents into another container and mix with any drugs.
Terms of sale
The drug release is strictly prescription
Storage conditions
Prevenar should be stored at 2-8 ° C without freezing, out of the reach of children.
Shelf life
3 years.
Analogs
The main counterparts of the drug are: A vaccine for the prevention of hepatitis B and Pneumo 23.
Prevenar 13 or Pneumo 23 - which is better?
Many parents are willing to your child vaccinated by pnemokokkovyh infections, but do not know how to choose the vaccine: Prevenar 13 or Pneumo 23 ? Experts recommend to opt for Prevenar 13, although it and fewer serotypes, but since this drug produces a better immune system, and the efficiency of its above.
Reviews of Prevenar
It should be noted, that the the inoculation Prevenar, reviews about the which the are encountered in large quantities on the of every possible the forums, causes a lot of of disputes and doubt about it. Of course, many parents like prevention seems very attractive, but some of them did not believe in its effectiveness. Moreover, often they find these vaccines cause of side effects and even deaths among children.
Also, the network can find reviews of doctors of Prevenar. Expert opinion about this vaccine is very different character. While some positive results describe vaccination, others indicate certain facts, such as the fact that the drug does not include serotypes 1 and 5, which are the main cause pneumococcal infection. Furthermore, reportedly that this vaccine temporarily banned in some countries, e.g., in Netherlands.
Often people say that to carry out vaccination to persuade them to private clinics. It is sometimes found reports of side effects in the form of fever. In general, reviews of Prevenar 13 contains information that vaccination is successful without the development of adverse events. Parents say that strictly adhere to all the recommendations of doctors and always kept a set interval between doses. After that, the children get sick less, and they quietly visited a kindergarten and other public places.
Price of Prevenar, where to buy
Prevenar can be purchased at a cost of 2600 rubles. Price Prevenar 13 amounts to 2160-2500 rubles.
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