Description overdue on 11/13/2014
- Latin name: Sunpras
- ATC code: A02BC02
- Active substance: Pantoprazole (Pantoprazole)
- Manufacturer: Ltd. San Pharmaceuticals Industries, India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Sanpraza (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In one tablet: pantoprazole sodium sesquihydrate - 45 1 mg (40 mg calculated as pantoprazole ) + Calcium carbonate, sodium lauryl sulfate, colloidal silica, magnesium oxide, crospovidone, calcium stearate, triethyl citrate, titanium dioxide, Macrogol 6000, methacrylic acid and ethyl acrylate as copolymer, copovidone, talc, yellow iron oxide.
In one bottle: contains 40 mg pantoprazole 0 + 9% solution sodium chloride .
Product form
The drug release in the form of tablets yellow enteric-coated. The shape - round, convex. On 10 pieces of aluminum strips. In a cardboard bundle one by one, two or three strip.
The drug is also produced in the form of white lyophilisate . The clear glass vials of 40 mg. The set sold clear, colorless solvent with a capacity of 10 mg.
Pharmacological action
An inhibitor of the proton apply.
Pharmacodynamics and pharmacokinetics
The drug - inhibits the process Proton alluvium enzymes H + -K + -ATPase .
There is a lock generation hydrochloric acid at the last stage of the process is reduced basal and stimulated secretion, irrespective of the origin of a particular stimulus.
If the patient has gastric ulcer Caused by bacteria Helicobacter pylori Then by reducing the production hydrochloric acid increases the sensitivity of bacteria to Antibiotic . It is noteworthy that the preparation has no effect on normal motility GI .
After taking the pills therapeutic effect occurs within one hour, it reaches a maximum of 2-4 hours. After 3-4 days after receiving funds secretion of hydrochloric acid and other substances it bounces back. The substance stable at neutral pH It does not affect the oxidase system liver, which depends on the enzyme P450 .
When administered orally, the active ingredient is rapidly absorbed in GI . Cmax in blood plasma, which is equal to 2-3 ug per ml is achieved after 3 hours. About 98% pantoprazole bound to plasma proteins. Concurrent food intake does not affect the pharmacokinetic indicators. Frequent and prolonged use of this index remains constant.
The half - one hour. The drug undergoes metabolism in the liver reactions. Metabolites are excreted through the kidneys and feces.
The drug is not cumulated in the body. For persons suffering from renal failure on hemodialysis , Dosage adjustment is not required.
With cirrhosis half-life is increased to 7 to 9 hours and a maximum concentration of 1, 5 times more.
Older people have slightly increased the maximum concentration in the blood and AUC drug. However the daily dose correction is not required.
When administered intravenously, figures similar to the intake of tablets.
Indications
The drug is prescribed:
- at syndrome Zollinger-Ellison ;
- for the treatment and prevention ulcers Caused by stress;
- at erosive gastritis , Including those related to the reception NSAIDs ;
- treatment GERD ;
- treatment stomach ulcers and duodenal Usually in the acute form;
- to eliminate bacteria Helicobacter pylori in combination with antibiotics ;
- for the treatment of bleeding perforations and Penetration Arising as a complication of stomach ulcers .
Contraindications
The drug is not prescribed:
- at indigestion Caused by disorders of neurotic character;
- children;
- at allergies on the components of the means;
- at oncological diseases stomach and intestine.
In the presence of liver disease, cirrhosis of the liver and in pregnancy medication prescribed with caution.
Side effects
When receiving the drug may occur:
- depression . headache . disorientation . hallucinations and confusion ;
- thrombocytopenia . leukopenia ;
- thrombophlebitis and phlebitis ;
- epigastric pain, constipation or diarrhea , Nausea, flatulence Dryness of mucous membranes, jaundice , Increased liver enzymes;
- arthralgia . myalgia ;
- hives . itching . anaphylactic shock . erythema . angioedema . photosensitization . Stevens-Johnson syndrome ;
- temperature rise or the level of triglycerides . jade .
Instructions for use Sanpraza (method and dosage)
Depending on the patient's physician must assign a particular dosage form facilities.
Tablets Sanpraz, instructions for use
The tablets are taken orally, with some liquid, and not raskusyvaya not crushing them. It is best to take the medicine in the morning on an empty stomach one hour before the first meal.
With stomach ulcer appoint 40-80 mg per day for the treatment and 20 mg daily for prophylaxis. Course duration is 4-8 weeks.
With duodenal ulcer and erosive gastritis daily dosage of 40-80 mg for the prophylaxis and take 20 mg agent per day. The course of treatment - two weeks.
To eradication bacteria Helicobacter administered 80 mg daily for 2 doses. The duration of treatment 7-14 days. In parallel, usually prescribe antibiotics.
With erosion of the gastrointestinal tract Drug-induced NSAIDs Daily dose - 40-80 mg, 20 mg for prevention. The course of treatment - up to 2 months.
For treatment reflux esophagitis using 20-40 mg per day. For prevention - 20 mg. Duration - 4-8 weeks.
Instructions on intravenous solution
This form of medication prescribed for the inability to use the tablets. As soon as possible, switch to tablet form.
To prepare the solution should be mixed the contents of the vials.
The solution was administered bolus or through an IV. Time input - from 2 to 15 minutes, pH the solution is 9-10. After 3 hours, the prepared solution becomes unsuitable for administration.
Generally, using 40 mg (one bottle) per day. Acceptable to make intravenous injections for 7-10 days.
The maximum amount of the drug per day is 80-160 mg. The dose should be divided into 2 injection.
If the patient has severe disorders of the liver, the maximum daily dose is 20 mg. During treatment should closely monitor the level of liver enzymes.
If the patient is on hemodialysis or in old age, dosage should not exceed 40 mg per day.
Overdose
No cases of overdose. When administered intravenously, 240 mg of the means of any significant changes in the patient's condition was observed.
If overdose is yet occurred, is shown symptomatic therapy, detoxification measures, conduct Hemodialysis .
Cooperation
The combination with Sanpraza ketoconazole . ritonavir and iron salts reduces their absorption due to changes pH gastric juice.
The drug can be combined with digoxin . metoprolol . clarithromycin . diclofenac . naproxen . glibenclamide . diazepam, phenytoin, tacrolimus, midazolam, theophylline, ethanol, caffeine, nifedipine, amoxicillin, oral contraceptives, fenazolom , Piroxicam, levothyroxine sodium, carbamazepine, cyclosporine, cisapride, metronidazole .
At the same time taking the drug and atazanavir , The effectiveness of the latter decreases.
If you take the medicine, and Warfarin A change occurs prothrombin index , May cause bleeding. Concerning PTI It needs to be carefully monitored.
Terms of sale
It requires a prescription.
Storage conditions
Store in a dry, dark place and children. The temperature is not above 30 degrees.
Shelf life
Tablets - 3 years.
Lyophilisate - 2 years, at the solvent - 3 years.
Cautions
Before the appointment of agents to exclude the likelihood of cancer at GI . The drug can mask the symptoms and delay the date of the correct diagnosis.
If at the end of treatment improvements in the state not yet occurred, it is necessary to review the diagnosis and make further examination.
Analogs Sanpraza
Losek MAPS
Losek
Emanera
Omez
Insta omez
Rabeprazole
Kontrolok
Ortanol
Nexium
Nolpaza
Geerdin
Omeprazole
Lansoprazole
The closest analogues of the action Sanpraza: Zipantola, Kontrolok, Peptazol, Panum, Omez, Nolpaza, Proksium .
During pregnancy and lactation
Not recommended to prescribe the drug during pregnancy. There is a slight embryotoxicity facilities. When receiving Sanpraza need to stop breastfeeding.
Reviews Sanpraze
On the Internet, mostly positive reviews about Sanpraze. The tool effectively and efficiently. Some complain of side effects such as diarrhea . dizziness and nausea , The high cost of the drug.
Price Sanpraza
Price Sanpraz 40 mg - 479 rubles for 30 tablets.
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