Description overdue on 12/12/2014
- Latin name: Oftan Timogel
- ATC code: S01ED01
- Active substance: Timolol (Timolol)
- Manufacturer: Ekselfizhn AG, Switzerland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Oftan Timogel (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The structure of one gram of tools includes: 1, 37 mg timolol maleate - This corresponds to 1 mg timolol . Also in the supporting elements has: carbomer, polyvinyl alcohol, benzalkonium chloride, lysine monohydrate, sodium acetate trihydrate, water, sorbitol .
Product form
Oftan Timogel produced in the form of a gel. Gel no odor and color capable of opalescence. Carton boxes plastic bottles of 5 g.
Pharmacological action
Antiglaucoma drug .
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug Oftan Timogel - nonselective Beta-blockers . It has the ability to reduce intraocular pressure By reducing the intensity of the production of aqueous humor.
Antiglaucoma drug It affects the process of outflow of the fluid inside the eye. Also it means has a weakly pronounced anesthetic effect, has no effect on accommodation of and pupillary size. Deterioration of vision or night blindness during the use of funds is not observed. The mechanism of action of the active ingredient are not yet fully understood.
The effect of the drug develops within a few hours after instillation lasted for 24 hours.
The drug may penetrate into the systemic circulation through small vessels conjunctiva , Lacrimal tract or the nasal mucosa. Rarely a half hour after the use of the drug can be detected in the serum. Note that timolol excreted in breast milk and is found in low concentrations in the urine over a long period after ingestion.
Indications
Oftan Timogel appoint:
- at elevated intraocular pressure ;
- treatment open-angle glaucoma ;
- at uveal, posttraumatic, afakicheskoy glaucoma .
Contraindications
The drug is contraindicated:
- at degenerative diseases of the cornea eyes;
- at cardiac arrhythmias ;
- at bradycardia ;
- people suffering asthma ;
- in chronic obstructive bronchitis from bronchospasm ;
- at AV-blockade second and third degree;
- at cardiogenic shock ;
- individuals who are prone to allergic reactions to components or tools timolol maleate .
Care should be taken:
- at pulmonary disease ;
- under the age of 12 years;
- in severe cerebrovascular insufficiency ;
- sick diabetes ;
- at thyrotoxicosis . hypoglycemia . myasthenia ;
- combining the drug with other beta-blockers ;
- in chronic Heart Failure .
Side effects
The most common local reactions:
- discomfort in the eyes;
- pain and a burning sensation immediately after application of the gel;
- conjunctival hyperemia .
Rarely can occur:
- problems with visual acuity (tested in 3 minutes);
- special sensitivity to light, watery eyes;
- edema epithelial tissue in the cornea;
- hyperemia century ;
- conjunctivitis . ptosis . blepharitis . keratitis ;
- the appearance of a persistent impairment ( violation of refraction . diplopia , Superficial punctate keratopathy );
- dry eye syndrome .
The following adverse reactions may occur in the event that drug has penetrated into the systemic circulation.
FEATURES:
- reduction Blood Pressure . bradycardia . heart failure . arrhythmia , Cardiac arrest;
- bronchospasm . breathlessness Cough;
- fainting , Circulatory disorders of the brain, Raynaud's syndrome ;
- myasthenia . asthenia . headache . depression . Sleep disorders , Nightmares, decreased ability to remember, paresthesia ;
- poor circulation in the hands and feet and the resulting feeling of cold in the extremities;
- hives . erythema . psoriasis skin, and other skin allergic reactions ;
- nausea, diarrhea, dryness of mucous membranes, indigestion;
- asthenia . Peyronie's disease , Reduction libido . systemic lupus erythematosus , Fatigue, erectile dysfunction .
Instructions for use Oftan Timogel (method and dosage)
According to the instructions, assign one drop of the gel once a day.
If there is a need to use other drugs, the gap between the drugs must be at least 5 minutes. Drops for eyes, it is desirable to use before applying the gel.
The course of treatment is determined by the attending physician.
Overdose
The likelihood of overdose when used properly, is extremely small.
In case of overdose are observed: angina . bronchospasm . bradycardia , Reduction Blood Pressure . AV-block .
Treatment - gastric lavage (if the gel was in the digestive tract). Hemodialysis ineffective.
Also shown is symptomatic therapy: an introduction atropine sulfate . isoprenaline Installing artificial pacemaker, dopamine . norepinephrine . dobutamine . glucagon . aminophylline .
If there was an acute heart failure, should be used diuretics Oxygen, preparations foxglove . aminophylline . glucagon .
Cooperation
Precautions to combine medication with nifedipine , Drugs foxglove . verapaminom . clonidine . diltiazem . lidocaine (intramuscularly) and radiopaque agents Containing iodine .
When combined with funds reserpine (a sympathomimetic) may increase unwanted side reactions.
The drug itself has no influence on pupil size, however, if it is combined with simpatomimetikami (eg, epinephrine ) Is observed mydriasis .
Use caution when combined with drugs systemic beta-blockers As possible a strong decline Intraocular pressure .
During treatment should refrain from drinking alcohol and weapons with a part ethanol .
Antipsychotics and antipsychotic drugs in combination with the drug may cause a sharp decrease Blood Pressure .
Strong reduction Blood Pressure , Cardiac conduction, left ventricular failure - Adverse reactions occurring in combination with the drug blockers, calcium glowing . Particular caution should be observed when calcium channel blockers are administered intramuscularly.
Antiarrhythmic preparations of class 1 and 3 in combination with beta-blockers can slow the conduction in atria , Reinforce negative inotropic effect .
Patients who suffer diabetes (Host insulin and oral hypoglycemics ) We must remember that beta-blockers can mask the symptoms hypoglycemia Such as palpitations heartbeat and tachycardia .
When combined with Oftan Timogel cimetidine Content in blood plasma timolol may rise significantly.
Terms of sale
In order to buy medicine requires a prescription.
Storage conditions
Store this medication away from children. Temperature range - not higher than 25 degrees, the medicine must not be frozen.
After opening the bottle it has to be stored upside down in a cardboard box.
Shelf life
A year and six months.
Once opened, the medicine may be stored for months.
Cautions
At angle-closure glaucoma It is recommended to combine the drug with miotikami .
If during treatment there any dermatologic reactions should stop taking the drug and contact your doctor.
Patients suffering heart failure, you need to carefully monitor the work and the state of the heart muscle during treatment agent.
In connection with the typical side effects to drive or perform precision operations that require special attention or concentration of the reaction rate, it is not recommended.
Analogs
Timolol
Betoptik
Arutimol
Timolol, Arutimol, Kuzimolol, Glaumol, Okumed, Oftimol, timolol maleate . Arutimol .
During pregnancy and lactation
Acceptance of the drug in pregnant women is possible only after consultation with a specialist.
When breastfeeding, because the medicine gets into the milk, breast-feeding should be discontinued.
Reviews
Reviews of preparation is extremely small. Of those that are - all positive.
Cost
You can buy the medicine for 235 rubles per bottle.
Where to buy Oftan Timogel? Buy drug at any online pharmacy.
No comments:
Post a Comment