Description overdue on 11/11/2014
- Latin name: Melatonin
- ATC code: H06A
- Active substance: Melatonin
- Manufacturer: "Healthway Production Inc.," US
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for Use Melatonin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The product contains the active ingredient melatonin As well as a number of supporting components: microcrystalline cellulose, anhydrous dibasic calcium phosphate, magnesium stearate, colloidal silicon dioxide, croscarmellose sodium, stearic acid.
Product form
Melatonin is produced in tablets, which covers the film coating. The blister packed for 12 tablets.
Pharmacological action
Sleep hormone melatonin is produced by the pineal gland in the human body, which is located at the base of the brain. This substance contains animal food, food of plant origin is a smaller amount of this hormone. The secretion of melatonin is also dependent on the degree of illumination. In low light its products increases, with good - inhibited.
In humans, at night it produced approximately 70% of the daily quantity of the hormone. Under the action of melatonin increases the amount of gamma-aminobutyric acid and serotonin in the hypothalamus and midbrain.
Melatonin is a solid substance, it can absorb or dissolve fat. It is very strong antioxidant natural origin. During the synthesis of the hormone system provides protection against the effects of free radicals which provoke accelerated aging processes and malignant diseases. This substance may penetrate into body cells ce and provide specific protection to the kernel. As a consequence, there is a restoration of damaged cells.
Hormone melatonin also exists in the synthetic form, used as an additive, which It provides a hypnotic influence And also acts as a antioxidant . This hormone is a natural regulator of the circadian rhythm, providing a healthy sleep, rapid falling asleep and waking.
If a person puts the body time to adapt disorders, hormone corrects the body's circadian rhythms, as well as the regulation of the cycle of wakefulness and sleep. Tablets Melatonin make it easier to fall asleep in atypical for this time, reduce the frequency of awakenings during the night and normalize sleep in general.
The drug has a sedative, adaptogenic and sedative effects when taken in high doses, also noted the impact of antioxidant and immunostimulant. Also under its influence it decreases the frequency of seizures manifestations headache Decreases the intensity of the stress response, regulation of neuroendocrine functions occurs.
Before taking the patient must read the manual, which is used Melatonin is what it is and how it acts on the body.
Pharmacokinetics and pharmacodynamics
Wikipedia indicates that the drug takes effect 1-2 hours after oral administration. Getting inside, melatonin during the initial passage through the liver is converted. The level of bioavailability is 30-50%. The substance is able to penetrate the blood-brain barrier. The average half-life of 45 minutes. Because the body it is excreted through the kidneys.
Indications
It should be understood taking melatonin, which is a drug that promotes sleep onset.
Therefore, melatonin formulations are prescribed in the following diseases and conditions:
- insomnia ;
- condition of the body, in which marked sleep disturbances;
- the need to regulate the biological cycle of waking and sleeping;
- the need for feedback as an antioxidant to protect against the effects of free radicals;
- to stimulate the immune system;
- to stabilize the regulation of blood pressure and blood cholesterol;
- prophylaxis of tumor diseases;
- disturbance of mental adaptation;
- anxiety and depression;
- normalization of sleep in older people.
Contraindications
Defines the following contraindications:
- high sensitivity the components;
- autoimmune diseases;
- lymphoma;
- Hodgkin's disease;
- leukosis ;
- diabetes ;
- myeloma;
- epilepsy ;
- pregnancy and lactation;
- children's age.
Caution is necessary to take the drug to people who by occupation is necessary to concentrate. Also, caution is indicated for hormonal disturbances during hormone replacement treatment for people suffering allergic diseases .
Side effects
When you receive it should be remembered that this treatment can cause the manifestation of side effects. In particular, it may appear the following side effects: weight and stomach discomfort, headaches, heaviness in the head, depression . If the treatment manifest these or other side effects, it is necessary to tell the physician.
Instructions for Use Melatonin (method and dosage)
Instructions on Melatonin provides that the pills are taken orally, while they do not need to crack. Wash down the means to be water. Adult patients should drink before going to bed 1-2 tablets. Adolescents who have already turned 12 years old, is appointed on 1 tablet before bedtime. Instructions for Use Melatonin provides that the pills held for 30-40 minutes before bedtime. At night you can take no more than 6 mg of material.
How to take the tablets in each case explains the doctor.
Sports nutrition, including melatonin, should be carried out strictly under the supervision of specialists.
Overdose
There is insufficient data on overdose funds. When receiving a 24 mg means patients have prolonged sleep, memory problems, disorientation. To treat gastric lavage is necessary to take chelators . It is also practiced by symptomatic therapy.
Cooperation
At reception Aspirin , Beta-blockers may reduce the body's level of melatonin.
If at the same time taking melatonin and tranquilizers, sedative antidepressants, the effect of melatonin may decrease.
Possible impact on the effectiveness of hormonal methods.
Under the action of melatonin increases the level of binding to the specific benzodiazepine receptors. Hence, such a combination is only possible with careful control of the physician.
In an application potentiated the antitumor effect of tamoxifen.
Simultaneous treatment may increase the dopaminergic and serotonergic effects of methamphetamines.
When treating Melatonin potentiated the effect of antibacterial Isoniazid .
Terms of sale
Pharmacies vehicle sold without a prescription.
Storage conditions
Save means you need at room temperature, the need to protect the tablet from the reach of children. After the expiration date can not drink the medicine.
Shelf life
You can store the drug for 3 years.
Cautions
It should be noted that the pill may experience an adverse impact on the concentration, the rate of physical and mental reactions. Not recommended during therapy to drive vehicles and to perform potentially hazardous activities that require special attention.
When treating Melatonin should not smoke and drink alcohol.
Women who want to become pregnant, you should know that melatonin can act as a weak contraceptive .
During the medication should avoid overly bright lighting.
Analogs
Melatonin analogues of the drug - drug Melapur . Melaxen . Yukalin . Melaton . Despite the fact that these funds have a similar impact, should not be used without prior concentration of analogues with the doctor.
Babies
Children under 12 years of this medication is not administered. To normalize the sleep you can use products containing this substance. This, above all, food of animal origin. Which foods contain melatonin, detail can tell the doctor.
With alcohol
Between Melatonin treatment of alcohol use is not desirable.
During pregnancy and lactation
It is forbidden to assign these tablets period of gestation and breast-feeding .
Reviews of Melatonin
Reviews Melatonin indicate that the hormone of sleep really normalize the biological rhythms, positively affects the quality of sleep, it helps to get rid of insomnia. Reviews of doctors and patients indicated that the drug rarely causes significant side effects and is well accepted by the body.
Price Melatonin, where to buy
Tablets for sleep Melatonin is available over the counter. Buy Melatonin in Moscow can be as low as 700 rubles for 100 pills. Buy Melatonin in St. Petersburg may be the same price. Price Melatonin tablets in Ukraine is an average of 80 hryvnia per 100 tablets.
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