Pregnil

Description overdue on 10/26/2014

• Latin name: Pregnyl
• ATC code: G03GA01
• Active substance: Human chorionic gonadotropin (Human ChorionicGonadotropin)
• Manufacturer: Organon (Netherlands)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use -pregna (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

Active ingredient - human chorionic gonadotropin .

Additional components: carmellose sodium . sodium hydrogen phosphate . mannitol . sodium dihydrogen .

Product form

Pregnil (Pregnyl) is sold in vials lyophilized powder   to infusions . They are contained in blisters. Included is a solvent ampoules. In one box has three sets.

Pharmacological action

Gonadotroponah   means.

Pharmacodynamics and pharmacokinetics

For women, the drug is used as a substitute release of endogenous LH   in the middle of the cycle. This tool is prescribed for planning pregnancy   as an auxiliary method to artificial insemination with the aim to support luteal phase of the menstrual cycle   or to improve the function of the ovaries. For men, it is used to enhance the educational process Testosterone .

The maximum concentration of active ingredient is achieved after dosing for 20 hours in women and in men 6-16 hours. About 80% Human chorionic gonadotropin is metabolized   kidney.

Indications

This tool has the indications for men and women:

• for women - ovulation induction   and superovulation Maintaining function luteum ;
• for men - hypogonadism , Delayed puberty in the event of failure gonadotropnoj   functions pituitary , Violations spermatogenesis . cryptorchism .

Contraindications

You can not use in patients with:

• hypersensitivity   to its components;
• tumors Associated with sexual hormones.

In addition, the boys did not use the drug in case of early puberty, and for women - if the sex organs are formed with deviations that are not compatible with pregnancy, as well as incompatible with pregnancy uterine fibroids .

Precautions should be taken medication, if women have the risk of thrombosis But men have a latent or explicit heart failure . arterial hypertension . migraine Problems with the kidney function, epilepsy . Under the supervision of a specialist in the use of pregna must also be boys prepubertal age   in order to avoid early closure epiphysis   or puberty. It is necessary to monitor the development and growth of the skeleton.

Side effects

Patients of both sexes in the application of the drug may cause the following side reactions:

• generalized rash ;
• fever ;
• reactions at the injection site: bruising, redness, itch , Pain, swelling.

In women, the appointment of pregna may appear:

• thromboembolism ;
• pleurorrhea ;
• pain in the abdomen;
• nausea;
• diarrhea ;
• ascites ;
• junk ovarian hyperstimulation ;
• ovarian hyperstimulation syndrome ;
• breast tenderness;
• enlargement of the ovaries and ovarian cysts;
• big ovarian cysts ;
• weight gain.

The men and boys were seen side effects such as:

• sodium and water retention;
• gynecomastia .

Instructions for use -pregna (method and dosage)

Instructions on Pregnil 5000 and other forms of release of the drug reported that the drug is used in the form of injections. It also tells how to prick the tool for patients: the solvent is mixed with liofilizatom And the solution was slowly introduced subcutaneously   or intramuscularly .

Dosages in each case individually:

• at hypogonadism , Delayed puberty and disspermii   prescribe 1000-2000 IU 2-3 times a week;
• at cryptorchidism   children up to 6 years of 500-1000 IU administered 2-3 times a week, and older children are doing the injection Pregnil 1500 2-3 times a week. Therapy for up to 6 weeks. If necessary, it can be repeated;
• with the aim of ovulation induction   after treatment Humegonom   5000-10000 IU drugs used once;
• in order to maintain phase luteum   appoint 5000-10000 IU injection 1-3 times. The drug is administered for 9 days after Ovulation   or   follicle puncture .

Overdose

It is assumed that higher doses may cause ovarian hyperstimulation syndrome .

Cooperation

Drug interactions of agents with other drugs has not been studied.

The forums are also often interested in such a combination as Pregnil 1500 and a pregnancy test. Experts recommend to carry out a pregnancy test no sooner than 10 days after the last infusion of the drug. Some doctors say that after Ovulation   or replanting embryo   and all must be not less than 2 weeks before it will be possible to carry out the test. So women should not make premature conclusions: the results can be false positive And false negative .

To obtain reliable data needed to monitor the level Human chorionic gonadotropin   in dynamics. This is best done by laboratory blood tests.

Terms of sale

The drug is released from pharmacies by prescription only.

Storage conditions

The optimum temperature for storage of tools - from 2 to 15 ° C. In a place where kept the drug should not be exposed to sunlight. The vials should be protected from children.

Shelf life

Shelf life - three years. Do not use it after the expiration of this period.

Analogs

Match code ATC 4th level:

• Gonal-F
• Puregon
• Menopur

The drug has the following analogs:

• Chorionic Gonadotropin ;
• Profazi ;
• Horagon ;
• Ovitrel ;
• Ekostimulin .

All of the analogs have use of its own nuances, so do not use them without a prescription.

Ovitrel or Pregnil - which is better?

Many doctors say that both means are identical, and the difference between them is actually just low. Some patients, however, report that it is more convenient to use Ovitrel . In addition, there are cases when the drug was more effective than its counterpart. So it is believed that such a high price of the drug is fully justified.

Reviews Pregnile

Reviews on Pregnil 5000 and other forms of the drug are quite common. As a rule, they are left to women who are struggling with infertility. They use the medicine for stimulation and regulation of ripening follicle .

Reviews Pregnile not report discomfort and adverse reactions. Its application is painless. However, in each case, the action of the drug alone.

Unfortunately, it is difficult to find a forum in which their opinions are divided after applying -pregna men. However, concise reviews can be concluded that the use of drugs goes quite well.

Price -pregna where to buy

Price pregna may vary depending on the amount of drug in the vial. For example, buy Pregnil 5000 in Moscow and other Russian cities can be an average of 500 rubles. Price Pregnil 1500, in turn, about 1200 rubles. Some patients, however, require large doses. They are interested in what the price Pregnil 10000. However, this form of release of the drug is not. Thus, in this case we need ampoule Pregnil 5000 in duplicate.

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