Klimonorma

Description overdue on 08/12/2014

• Latin name: Klimonorm
• ATC code: G03FB09
• Active substance: Levonorgestrel + Estradiol (Levonorgestrel + Estradiol)
• Manufacturer: Jenapharm (Germany)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on klimonorma (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The package contained two types of pills: brown (12 pcs.) And yellow (9 pcs.).

1 yellow pills containing 2 mg Estradiol valerate . 1 tablet brown contains 150 micrograms levonorgestrel   and 2 mg estradiol valerate. Auxiliary components: carnauba wax, magnesium stearate, potato starch, lactose monohydrate, polyvidone, titanium dioxide, calcium carbonate, magnesium carbonate, purified water, macrogol, glucose, gelatin.

Product form

The drug comes in the form dragee . Each pack contains 1 cardboard blister pack with a special calendar scale (21 pills).

Pharmacological action

Protivoklimaktericheskoe means Containing a progestogen and estrogen . In the female organism estrogen, present in the preparation in the form of oestradiol valerate, natural metabolized to 17-beta estradiol. With the addition of levonorgestrel (a progestogen) 12 days of each cycle fails to prevent the development of cancer and endometrial hyperplasia . In patients suffering from irregular menstruation, against taking medication stabilized and leveled menstrual cycle   (important for women with a uterus unremoved).

Estradiol is able to compensate for the deficiency estrogen   in women under attack Menopause   and allows you to stop the negative psycho-emotional symptoms, autonomic symptoms:

• dizziness ;
• excitability;
• flushes the blood flow to the face;
• irritability;
• decreased libido;
• sweating;
• kardialgiya;
• migraine headache ;
• joint pain;
• sleep disorders;
• nervous irritability;
• muscle pain;
• vaginal dryness;
• pain during sexual intercourse.

With a lack of estrogen there is a loss of bone mass. Estradiol prevents bone destruction. The principle is based on the effects of bone remodeling shift (towards the bone formation) and suppressing osteoclast activity. It is proved that the long-term hormone replacement therapy can significantly reduce the risk of fractures in women with the onset of menopause. Choosing the right hormone therapy slows the aging process, the formation of facial wrinkles, increases the level of collagen in the skin, charitable acts on its density.

Additionally, the drug reduces cholesterol Stabilizing the ratio of the lipid profile. It was noted that against the background of hormone therapy in postmenopausal women reduced the risk of developing colon cancer .

Pharmacodynamics and pharmacokinetics

Two active substances quite rapidly absorbed from the digestive system. Estradiol valerate passes changes metabolizing to 17-beta-estradiol and estrogen. Levonorgestrel is excreted in the bile   and urine in the form of specific conjugates. Estradiol is excreted as metabolites in the urine of 90%. The largest part of levonorgestrel (about 95%) comes into contact with the globulin and albumin that bind hormones.

Indications

• urogenital dystrophy (reverse form of female genital mutilation);
• menstrual irregularities in the background menopause ;
• atrophic changes in the mucous membranes and skin (thinning, dryness);
• warning osteoporosis ;
• emotional instability on the background of climacteric syndrome;
• hormone therapy after removal of the ovaries surgically;
• irritation of the urinary tract and bladder, urinary incontinence   under stress at the time of menopause.

Contraindications

• hereditary pathology of lipid metabolism;
• neoplasms of liver tissue, liver disease, severe;
• Individual hypersensitivity ;
• myocardial infarction ;
• thromboembolism ;
• abnormal genital bleeding, endometriosis ;
• diagnosis or suspicion of the presence of hormone-dependent tumors of the breast, ovary, uterus;
• acute stage cerebrovascular accidents ;
• vynashivanie pregnancy ;
• diabetic angiopathy, heavy for Diabetes ;
• breast-feeding ;
• progressive otosclerosis, herpes infection . itching Idiopathic form jaundice .

Side effects

• gastrointestinal disorders;
• nausea;
• violations of the chair;
• vomiting;
• discomfort in the epigastric region;
• changes in libido;
• painful breasts;
• chloasma (dark spots on the skin) itching ;
• vaginal bleeding.

Instructions on klimonorma (method and dosage)

Instructions for use klimonorma while maintaining the menstrual cycle: Treatment starts with 5 days of the cycle (the first day counted from the onset of menstrual bleeding). With rare menstruation, amenorrhea In menopause to start taking the drug can be any day, excluding pregnancy. Packaging calculated at day 21. The treatment begins with the reception of yellow pills: 1 pc. every day for 9 days. Then, 12 days take 1 brown pills daily. Then make a 7-day interval, during which bleeding occurs, like menses. Then re-start the treatment, taking pills in the same way. Drops are not designed to razzhёvyvanie, they must be swallowed whole with water. It is recommended to take the drug every day at a particular time. When you pass a 1 tablet may come vaginal bleeding .

Overdose

Acute adverse reactions when taking high doses of the drug have been identified. Perhaps the development of vaginal bleeding, vomiting, nausea. Held posindromnaya therapy, specific antidote   It has not been developed.

Cooperation

Before treatment supersede all hormonal contraceptives. In order to prevent an unwanted pregnancy is recommended to resort to nonhormonal Contraception . Clinical efficacy and clearance of sex hormones are reduced while reception inducers of hepatic enzymes ( antibiotics , Anticonvulsants). A similar effect is observed in the treatment of Rifampicin . Carbamazepine , Barbiturates, Griseofulvin . The maximum rate of enzyme induction recorded after 2-3 weeks of therapy and may persist for 4 weeks after discontinuation of the drug. The fall in estradiol levels observed when taking Tetracycline and Penicillin.

Due to the competitive inhibition conjugation suction increases the bioavailability of estradiol amid simultaneous therapy drugs that are largely exposed conjugation (this includes Paracetamol ).

Patients with diabetes can vary glucose tolerance, which requires correction of the dose insulin   and hypoglycemic drugs. Admission alcoholic beverages may increase the level of estradiol in women.

Terms of sale

You can buy pills at the pharmacy by presenting a doctor's prescription form.

Storage conditions

Klimonorma refers to the list recommended by the manufacturer B. temperature regime - up to 25 degrees. Restrict uncontrolled admission of young children to the blister with pills.

Shelf life

5 years.

Cautions

What better Femoston or klimonorma?
If you choose a combined hormonal doctor always takes into account the age of the patient, contraindications, weight, comorbidities. Therefore, it is better to rely on the opinion of your doctor, who will take into account all the features and pick up exactly the medicine that is better suited for your body: Femoston or other combined hormonal medication.

In no case the medication should not be used as Contraceptive . Prior to treatment, be sure to survey the state of the mammary glands, liver system, cholesterol levels, blood pressure . When porphyria, multiple sclerosis , Otosclerosis, varicose veins . hypertension , Sickle-cell anemia carried out additional consultation of experts before hormone therapy. With increasing severity migraine headaches , In violation of the auditory or visual perception, stagnation of bile, thromboembolic disorders treatment ceased.

Analogs

Structural analogues:

• Femoston;
• Kliogest;
• Klimodien.

Medicines with a similar pharmacological effect:

• Estrovel;
• Onagris;
• Menopace;
• Inoklym;
• Feminal.

During pregnancy (and lactation)

During gestation and lactation, pregnancy, hormone replacement therapy is not performed. In case of accidental reception of hormones in early pregnancy teratogenic effects are not detected. The women who took to the pregnancy hormone medicines, have been reported increase in the number of congenital anomalies in children. The data were obtained from a large-scale epidemiological studies of steroid hormones. Some of the drug is excreted in breast milk.

Reviews klimonorma (opinion of patients and doctors)

Reviews of klimonorma women show no obvious adverse reactions during treatment. Patients indicate that the drug actually helps to cope with adverse psycho-emotional reactions, reduces irritability, excitability. Forums on relevant topics include reviews of doctors, who also confirm the high efficacy of the drug in the treatment of negative symptoms of post-menopausal period. In general, reviews of klimonorma positive.

Price klimonorma where to buy

Price klimonorma depends on the region and in the range 570-650 rubles. In Ukraine, the medication can be bought for 130 USD.

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