Ammifurin

Description overdue on 03.02.2013

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Photosensitizing agent.   The active component acts Ammi great fruit furokumariny. The main principle of the drug based on the sensitization of the skin to light: ultraviolet irradiation stimulates the production of melanin (skin pigment endogenous) melanocytes. If vitiligo Ammifurin use of the drug in conjunction with radiation can restore ulrafioletovym pigmentation   skin. Ammifurin available in tablet dosage form, in solution form.

Indications:

Instructions for use of the drug is recommended to appoint Ammifurin medication at total alopecia Vitiligo, psoriasis, mushroom avium, alopecia areata.

Contraindications:

Ammifurin not prescribed for liver cirrhosis, pancreatitis, peptic ulcer disease of the digestive system, acute gastritis, intolerance to the active substance, cachexia , Diabetes, nephritis, hepatitis, thyrotoxicosis , Multiple pigmented nevi, cataract, breastfeeding, tuberculosis, hypertension, blood diseases, tumors of benign and malignant nature, with decompensated endocrine diseases. Children and the elderly Ammifurin used with caution.

Side effect:

The feeling heart palpitations, dizziness, headaches, stomachalgia , Nausea, dyspepsia,   cardialgia .

Overdose:

Manifested in the form of swelling, blistering, redness of the skin , Acute dermatitis.

Mode of application:

Ammifurin pills taken by mouth after eating, drinking milk .  The highest single dose of 80 mg .  Medications administered 2 hours prior to UV irradiation at a dose of 0, 8 mg / kg once .  The solution was 0, 3% is used topically in combination with irradiation with ultraviolet rays of 320-390 nm long-wave .  The solution is applied for an hour before exposure to all areas affected .  Ultraviolet radiation is necessary to start with a half dose of biological, with a gradual increase to 5-6 biological doses that will match the duration of exposure to 1-2 minutes to 10-15 minutes .  In psoriasis treatments held on Monday, Tuesday, Thursday and Friday (4 treatments), and other diseases - 3-4 times a week .  Total exposure - 20 .  Repeat courses possible through 1-1, 5 months .  Patients with limited areas of the skin lesion treatment is carried out only externally, combining with ultraviolet light .

Special instructions:

With leykodermii   ( depigmentation of the skin ), Which is linked to the destruction of melanocytes, Ammifurin does not have an effective impact. The attending physician should warn the patient about the risk of bullous dermatitis   when the combination therapy of solar radiation and irradiation lesion mercury-quartz lamp .  From a patient requires strict observance of the prescribed by the attending doctor mode radiation .  In the daytime during treatment, patients are advised to wear sun glasses .  For the prevention of cumulative exposure to natural and artificial ultraviolet radiation treatment is recommended to be combined with fractionated radiation sunlight .  The highest efficiency is observed in younger patients, patients who are prone to sunburn, had black hair and a slight period of the disease .  Drug treatment must be carried out under Ammifurin, close supervision treating doctor .  Reviews on drug Ammifurin show the effectiveness of the drug in the treatment of vitiligo .  Vials and pills to keep away from children, keep away from direct sunlight .  Storage temperature Ammifurin - no more than 25 degrees Celsius .

Drug Interactions:

Clinically significant pharmaceutical Ammifurin interaction with other medicines have been identified.