Pyrazinamide

Description overdue on 25.05.2012

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TB drugs . The action is aimed at the basic substance mycobacteria located intracellularly. The active ingredient is well into the pockets of tuberculosis. The highest efficiency is marked by the action of an acid environment. Pyrazinamide is able to provide bacteriostatic and bactericidal effects. When concomitant administration of other anti-TB drugs reduced the likelihood of developing resistance. Pyrazinamide is available in tablet form.

Indications, contraindications:

Pyrazinamide is prescribed for tuberculosis. The drug is contraindicated if you are hypersensitive active ingredient. In gout, hyperuricemia and hepatic failure of pyrazinamide administered with caution.

Side effect:

Musculoskeletal system: arthralgia , Myalgia. The digestive tract:   aggravation of peptic ulcers, disorders of the hepatic system, diarrhea, nausea, "metallic" taste in the mouth, nausea, yellow atrophy of the liver, hepatomegaly , Loss of appetite, jaundice, liver tenderness. Nervous system:   depression, anxiety, headaches, confusion, hallucinations, convulsions, dizziness, sleep disturbances. Hemostatic system and organs of hematopoiesis: splenomegaly, hypercoagulation , Porphyria, vacuolation of erythrocytes, sideroblastic anemia, thrombocytopenia. Urinary system:   dizuricheskie disorders interstitial nephritis . It is also possible to develop acne , Urticaria, photosensitivity, acute gout, hyperuricemia, pyrexia, rash, increased serum iron.

Overdose:

Manifest violation of the nervous system, liver system. Therapy posindromnaya.

Mode of application:

Pyrazinamide taken after meals, inside, 1 time per day, preferably in the morning with water. The daily dosage for a 50 kg weight is at least 1, 5 grams, and weighs more than 50 kg - 2 grams. In some cases, the drug administered one time per week at a dose of 90mg / kg, or three times a week for 2, 5 grams, or twice a week for 3, 5 grams. In no more than 2 hours and 5 grams. Duration of anti-TB treatment is 3 months or more. When poor tolerability of medicines administered in 3 doses. Persons elderly daily appoint not more than 15mg / kg. Pyrazinamide can be combined with rifampicin . isoniazid . kanamycin . streptomycin , Aminoglycosides.

Special instructions:

Prolonged use of pyrazinamide requires monthly monitoring liver enzymes and levels Uric acid   in blood. In individuals with diabetes during the anti-tuberculosis therapy significantly increases the risk hypoglycemia .

Drug Interactions:

Pyrazinamide is compatible with other anti-tuberculosis drugs. Combination therapy with ethambutol   or   rifampicin   It is indicated for chronic destructive forms of the disease. In combination with rifampicin are at risk hepatotoxic effects . Increased toxicity, and reduced excretion of drugs observed while taking medications that block tubular secretion. Pyrazinamide can increase TB activity of lomefloxacin, ofloxacin.