Description overdue on 06/20/2014
- Latin name: Irifrin
- ATC code: S01FB01
- Active substance: Phenylephrine (Phenylephrine)
- Manufacturer: PROMED EXPORTS, Pvt. Ltd. (India)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Eye drops Irifrin, instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- Reviews
- Price, where to buy
Composition
One vial contains 10% Irifrin phenylephrine hydrochloride - 100 mg, and in one vial Irifrin 2, 5% - 25 mg.
Excipients: benzalkonium chloride, edetate disodium, sodium hydroxide, sodium hydrogen phosphate dihydrate, anhydrous sodium dihydrogen phosphate, sodium metabisulfite , Citric acid, sodium citrate , Purified water.
One vial Irifrin BC (without preservative) 2, 5% comprising phenylephrine hydrochloride - 25 mg.
Product form
Eye drops Irifrin is a clear, colorless or pale yellow solution. 5 ml of the solution in the vial or dropper bottle of darkened glass, one such Dropper bottle or vial of darkened glass in a carton box.
Irifrin BC available in tube-looks to 4 ml, 5 such tubes in a paper bag, 3 of the bag in a carton box.
Pharmacological action
Irifrin - drops, having alpha adrenomimeticheskim action: vasoconstriction, smooth muscle contraction.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Phenylephrine It is adrenomimetikami Having alpha-adrenergic activity. Upon receiving a usual doses it produces no stimulatory effect on the central nervous system.
For local use in ophthalmology stimulate the outflow of intraocular fluid constricts blood vessels of the conjunctiva and causes mydriasis ( mydriasis ).
Phenylephrine has a strong stimulating effect on alpha-adrenergic receptors in postsinapsah, has a negligible effect on the beta-adrenergic receptors the heart, he has almost no positive inotropic and chronotropic effects. The drug has vasoconstrictor (vasoconstrictor) action similar to the action of noradrenaline However it had phenylephrine weaker and longer.
Vasoconstriction occurs within 30-90 seconds after use, duration - 2-5 hours.
After administration (instillation) phenylephrine reduces pupil dilator, causing mydriasis . Mydriasis reached within 20-60 min after instillation; It continues after instillation of 2, 5% solution for 2 hours, 10% solution - 3-5 hours.
Pharmacokinetics
Phenylephrine easily penetrate into the tissues of the body. Maximum concentration in the blood occurs within 10-20 minutes after topical application. Pre-instillation anesthetics increases the absorption into the systemic circulation and prolong mydriasis . The drug is excreted in the urine in the original form (less than 20%) in the form of inert metabolites.
Indications
- The need to expand the pupil during ophthalmic diagnostic procedures (control posterior segment of the eye).
- Iridocyclitis (prevention of posterior synechiae and the weakening of exudation in the iris).
- Carrying out a provocative study in patients with narrow angle of the anterior chamber and the possible angle-closure glaucoma .
- The surgical ophthalmology at the preoperative preparation to expand the pupil.
- Differential diagnosis of deep and superficial injected eyes .
- Treatment glaukomotsikliticheskih crises .
- Implementation of laser surgery at the bottom of the eyes and vitreoretinal surgery .
- Therapy syndrome " red eyes "(To alleviate congestion and sensitivity of the eye membranes).
- Interior and local: to reduce the swelling of nasal mucosa and conjunctiva in allergic and colds diseases (in combined treatment; only Irifrin BC ).
- Parenteral: to increase blood pressure collapse and hypotension Caused by a decrease in vascular tone (for Irifrin BC ).
Contraindications
- Allergies to the drug.
- Closure or narrow-angle glaucoma.
- Diabetes .
- Severe disorders of the cardiovascular system ( arterial hypertension , Heart disease, aneurysm . tachycardia ).
- Thyrotoxicosis, hyperthyroidism.
- Application together and for 14 days after cessation of MAO inhibitor therapy.
- Mydriasis during surgery in patients with defective integrity of the eye, or in violation of the outflow of tear fluid.
- Concomitant use with tricyclic antidepressants, antihypertensives (including beta-blockers ).
- Congenital lack of glucose-6-fosfatgidrogenazy .
- Porphyria.
- Newborns with low birth weight.
Side effects
- On the part of the eye: conjunctivitis , Periorbital tissue swelling; may be a burning sensation, irritation, blurred vision, tearing, discomfort, increased intraocular pressure.
- After taking the drug may cause Irifrin reactive miosis . With repeated use of the drug at this time mydriasis usually less pronounced. This effect is typical for the elderly.
- Since the cardiovascular system: feeling the heartbeat, tachycardia . reflex bradycardia . arrhythmia . hypertension . occlusion of the coronary arteries of the heart, pulmonary embolism .
- Due to the strong contraction of the pupil dilator, caused by the action of phenylephrine, 35-45 minutes after the use of the anterior chamber cavity may appear small grains pigment leaf Iris . The slurry must be differentiated from the front uveitis or the presence of blood cells cavity anterior chamber.
- Skin: dermatitis .
- Very rarely using Irifrin (eye drops 10%) observed the appearance of serious violations, including vascular collapse, myocardial infarction and intracerebral hemorrhage .
Eye drops Irifrin, instructions for use
Instructions on Irifrin prescribes a topical drops.
Ophthalmoscopy used single use 2, 5% solution. For appearance mydriasis instillation of one drop sufficiently Irifrin 2, 5% in the conjunctival sac. Expanding zrvchka maximum strength is achieved after 20-30 minutes and lasts for 1-3 hours. If necessary, may be extended mydriasis For one hour which produced another instillation .
Children 12 years old and adults with weak dilation of the pupils to provoke diagnostic mydriasis It justified the application of a 10% solution without dose adjustment.
When conducting diagnostic single use 2, 5% solution may be used:
- provocative test in patients with narrow angle of the anterior chamber and the possible angle-closure glaucoma ;
- differential diagnosis type injected eyes (superficial or deep);
- iridocyclitis solution of 2, 5 or 10% is used to prevent the development and rupture appearing posterior synechia; to reduce the exudation into the anterior eye chamber (one drop Irifrin instilled into the conjunctival sac 2-3 times a day);
- relief glaukomotsikliticheskih crises . Phenylephrine produces hypotensive effect in this pathology. 10% solution is used 2-3 times a day;
- prepare patients for surgical interventions for 40-60 minutes to achieve mydriasis produced a single injection of a 10% solution; After destroying the integrity of the eye membranes repeated use of the drug is prohibited.
10% solution can not be used for the impregnation of tampons during surgery.
Irifrin BC It is also used:
- at hyperopia with a tendency to spasm of accommodation, accompanied by a high load on the eyes - the drug is instilled in the evening, along with a 1% solution cyclopentolate . In the standard visual load Irifrin BK bedtime 3 times a week;
- in the treatment of true and false myopia - 1 drop at bedtime every 3 days within one month.
Overdose
Symptoms of overdose: a manifestation of the systemic effect of phenylephrine.
Treatment: The recommended intake alpha-adrenoceptor blocking means, for example 5-10 mg phentolamine intravenously.
Cooperation
Pupil dilation is enhanced when used together and phenylephrine atropine .
Use of 2, 5 or 10% solution of the drug to the MAO inhibitors and for three weeks after their withdrawal must be carried out with caution, as in this case, possibly uncontrolled high blood pressure.
Using Irifrin 10% in combination with beta-blockers can cause acute hypertension .
Application together with simpatomimetikami may potentiate Cardiovascular effect of phenylephrine.
Terms of sale
The preparation is available strictly on prescription.
Storage conditions
Keep away from children. Store in a dark place at a temperature of 25 ° C.
Shelf life
Two years.
Cautions
Since the duration of the extension of the pupil can reach 1-3 hours patients may appear the feeling photophobia, therefore, to restore visual function, it is necessary to protect eyes from strong sunlight. Banned reading and watching television.
Perhaps the development of jet miosis , More common in the elderly after the application of phenylephrine, and reuse of funds leads to a weakening of mydriasis.
Because the drug contains as preservative benzalkonium chloride This can cause discoloration of soft contact lenses. Before applying Irifrin patient must remove the lens and wait 15 minutes after instillation Before you use them again.
Analogs Irifrin
Mezaton
The unprofitable, the most common eye drops following analogues Irifrin:
Mezaton . Baby Nazol . Nazol Kids . Fenefrin 10% .
Babies
The drug is approved for use in children.
Reviews Irifrin
Reviews of eye drops Irifrin quite positive. Posts about the ineffectiveness of the drug hardly occurs. If you use drops in ophthalmic practice for children and adults reviews Irifrin sometimes show appearance burning sensation in the eyes.
Price Irifrin
Price eyedrops Irifrin 2, 5% in Russia ranges from 333 to 409 rubles, Irifrin BC It will cost 484-510 rubles.
In Ukraine, eye drops Irifrin 2, 5% will be worth 58-83 hryvnia, and the price Irifrin BC will average 78 hryvnia.
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