Description overdue on 30.07.2014
- Latin name: Ciprinol
- ATC code: J01MA02
- Active substance: Ciprofloxacin (Ciprofloxacin)
- Manufacturer: KRKA (Slovenia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications tsiprinol
- Contraindications
- Side effects
- Instructions for use tsiprinol (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Synonyms
- Analogs
- With antibiotics
- With alcohol
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Pills Tsiprinol They are composed of Ciprofloxacin hydrochloride monohydrate Silicon dioxide, croscarmellose sodium, sodium carboxymethyl starch, magnesium stearate, povidone, microcrystalline cellulose, propylene glycol, titanium dioxide, talc.
As part of the solution Tsiprinol contains the following ingredients: Ciprofloxacin lactate Sodium chloride, sodium lactate, hydrochloric acid, water,
Product form
The drug comes in the form of an infusion solution. It is a clear liquid with a yellowish-green tint.
Also realized concentrate which is used to prepare a solution. It is a transparent or yellowish-greenish solution.
250 mg Tablets tsiprinol lenticular, are round, white, bevelled edges. Their cover film coating on one side of the tablet has a notch.
500 mg Tablets tsiprinol lenticular, are oval, white. The tablets were coated film coating on one side has a notch.
Tsiprinol 750 mg tablets are oval in shape, are white film coating, notching has on both sides of the tablet.
Pharmacological action
Tsiprinol (ciprofloxacin) has on the antibacterial action. It is a second generation fluoroquinolone monoftorirovanny. Under its influence it inhibits topoisomerase II, an enzyme that determines the replication and biosynthesis of deoxyribonucleic acid bacteria. He is actively involved in the process of cell division in bacteria and protein biosynthesis.
Tsiprinol bactericidal effect, it is most effective against gram-negative bacteria. Therefore, the drug used in the treatment of diseases caused by these bacteria.
There is also a certain number of tsiprinol susceptible Gram-positive bacteria: Staphylococcus spp., Streptococcus spp. It also affects the number of intracellular bacteria.
High efficacy observed in the treatment of infectious diseases, provoked by Pseudomonas aeruginosa. Tsiprinol maloaktiven against chlamydia, anaerobic bacteria, Mycoplasma. Fungi, viruses, protozoa generally are resistant to the drug.
Pharmacodynamics and pharmacokinetics
Ciprinol in tablet form is rapidly absorbed, falling into the gastrointestinal tract. At its absorption does not affect food intake, its bioavailability is not reduced. The bioavailability equals 50-85%. The maximum concentration of active substance in the blood observed after about 1-1 hours after taking 5 tablets. After absorption, the active substance is distributed in the tissues of the urogenital tract and of the respiratory, in synovial fluid, muscle, skin, adipose tissue, saliva, sputum, cerebrospinal fluid. Also it reaches the cells (macrophages, neutrophils), which determines its efficiency in the treatment of infectious diseases in which the pathogens are localized intracellularly.
The resulting biotransformation occurring in the liver appear less active metabolites. The drug is excreted through the kidneys, as well as by the action of extrarenal mechanisms (in the faeces, with bile). Half-life of the drug from the body is between 5 and 9 hours. Accordingly, effective therapy for sufficient means to take twice a day.
After the infusion solution intravenously tsiprinol maximum concentration is achieved after 1 hour. When administered intravenously marked active distribution in the tissues of the body, which have a higher concentration of active ingredient compared with blood plasma. Ciprofloxacin is well into the placenta.
In individuals with normal renal function, the half-life of the drug is 3 to 5 hours. Patients suffering from renal insufficiency, elimination half-life increases to 12 hours.
After the infusion of the drug eliminated via the kidneys. The unchanged output of about 50-70% of the drug, and 10% is excreted as metabolites remainder - through the digestive tract. Since breast milk is allocated a small percentage of the active ingredient.
Indications tsiprinol
Ciprinol assigned in need of treatment of infections that were provoked by microorganisms sensitive to ciprofloxacin, from which develops in humans and certain diseases. Consequently, the indications for use of the drug as follows:
- respiratory infections: bronchitis , Pneumonia, cystic fibrosis, bronchiectasis, etc .;
- Infectious diseases ENT : Otitis media, mastoiditis, sinusitis;
- infectious diseases of the urinary tract and kidneys : cystitis . urethritis , Pyelonephritis;
- Infectious diseases of genitals, and other pelvic organs : prostatitis , Epididymitis, endometritis, Chlamydia, salpingitis, etc .;
- Infectious diseases of the abdominal cavity : cholecystitis , Cholangitis, intraperitoneal abscess, diarrhea, developing as a result of infection, etc .;
- infections of skin and soft tissue : Ulcers, burns and wounds of infectious origin, cellulitis, abscesses;
- infectious diseases of the musculoskeletal system Septic arthritis, osteomyelitis;
- sepsis, infections in people with impaired immunity ;
- preventive measures for the prevention of infections in surgical and orthopedic surgery;
- therapy and prophylaxis of inhalational anthrax.
Contraindications
You can not assign tsiprinol the following diseases and conditions:
- high sensitivity to ciprofloxacin, other drugs belonging to the group of fluoroquinolones or to any other components of the means.
- pregnancy and while nursing;
- age 18 years (except for the treatment of complications provoked by Pseudomonas aeruginosa, for children 5 to 17 years old who suffer from cystic fibrosis lung is also used for the treatment and prevention of anthrax in children);
- you can not use the drug at the same time with tizanidine.
Be wary appoint patients with severe tsiprinol atherosclerosis cerebrovascular disorders of blood flow in the brain, as well as people suffering epilepsy , Mental illness, kidney or liver failure. It should closely monitor the condition of elderly people, who are undergoing drug treatment, as well as those who have observed a lack of glucose-6-phosphate dehydrogenase.
Side effects
- Digestive system : A set of dyspeptic symptoms, anorexia , Gepatonekroz, hepatitis, cholestatic jaundice, pseudomembranous colitis.
- Central nervous system: headache , Headache, fatigue and a high level of anxiety, fainting, seizures, tremors, agitation, increased intracranial pressure, depression, disturbances of consciousness, hallucinations and other psychotic reactions.
- Senses: blurred vision, smell, hearing, periodic occurrence of tinnitus.
- Cardiovascular system : Problems with heart rhythm, tachycardia , Lowering blood pressure, periodic flushing.
- Hematopoietic system : Anemia, leukopenia, thrombocytopenia, granulocytopenia, thrombocytosis, leukocytosis.
- The urinary system : Crystalluria, hematuria, glomerulonephritis , Polyuria, dysuria, albuminuria, bleeding, nephritis, kidney function decline azotovydelitelnoy.
- Allergy : Rash, itching skin, blisters and bleeding, petechiae, drug fever, edema, vasculitis, nodular erythema, rash, and others.
- Musculoskeletal system : arthritis , Arthralgia, tendon rupture, tenosynovitis, myalgia, edema.
- Other manifestations : Candidiasis, sensitivity to light, sweating, general weakness of the state.
- In laboratory parameters : Increase in liver transaminases and alkaline phosphatase, hypoprothrombinemia, hyperuricemia, hypercreatininemia, hyperbilirubinemia, hyperglycemia.
- When infuzivnom administration local reactions can occur.
Instructions for use tsiprinol (method and dosage)
How intravenous solution tsiprinol and Ciprinol 500 mg (tablets) is administered twice daily. In milder forms of infectious diseases of the urinary or respiratory tract, as well as diarrhea appointed by the single dose of 250 mg. In severe forms of diseases or complicated infections the patient should take 500 or 750 mg.
Instructions on tsiprinol 500 mg provides that for gonorrhea drug is taken at this dose once. If practiced intravenous means necessary to carry out a slow infusion, and the dose is 200-400 mg. If a patient diagnosed with acute gonorrhea He single intravenous 100 mg tsiprinol. For prevention of postoperative infectious complications in about 1 hour prior to the surgery the patient is administered 200-400 mg tsiprinol.
If the patient experiences disturbance in the kidney, the daily dose of drugs for oral administration are halved.
It should take pills before eating, it is important to drink plenty of water.
Overdose
In case of overdose there may be a manifestation of symptoms: dizziness , Headache, vomiting, nausea, diarrhea. In the case of severe overdose possible impairment of consciousness, tremors, convulsions, hallucinations manifestation.
Symptomatic therapy, it is important to ensure patient a sufficient amount of fluid to gastric lavage. Also appointed laxatives, activated carbon.
Cooperation
If at the same time treat Tsiprinol and Didanosine Then there is a decrease absorption of ciprofloxacin.
Under the influence of increasing concentrations of ciprofloxacin and increased half-life in the body of theophylline and other xanthines.
In a parallel treatment of ciprofloxacin and oral hypoglycemic agents, as well as indirect anticoagulants decreases prothrombin index.
Perhaps the development of seizures while taking ciprofloxacin and NSAIDs.
Absorption of ciprofloxacin in parallel can decrease the treatment antacids, drugs that contain ions of aluminum, iron, zinc, and magnesium. It is important to ensure that the interval between administration of these drugs is not less than 4 hours.
If simultaneously applied ciprofloxacin and cyclosporine nephrotoxicity is enhanced by the effect of the latter.
Metoclopramide activates the absorption of ciprofloxacin. As a consequence, the period of reaching its maximum concentration in the plasma is reduced.
In the treatment with ciprofloxacin and uricosuric drugs slows excretion of ciprofloxacin and increases its concentration in plasma.
When concomitantly with other drugs has antimicrobial action, as a rule, there is synergy.
Terms of sale
Tsiprinol sold in pharmacies by prescription.
Storage conditions
Store medicines needed in a dry, dark place, and the temperature should not be above 25 ° C.
Shelf life
It can be kept for 5 years.
Cautions
People who suffer from seizures, epilepsy, vascular disease and organic brain disease, ciprofloxacin may be given only if the vital signs.
If in the course of therapy lasting noted severe diarrhea should be excluded pseudomembranous colitis . Upon confirmation of the diagnosis of an urgent need to remove the drug and treat the patient.
If there is pain in the tendons, as well as the first signs of tenosynovitis, treatment is suspended, as fluoroquinolones for the treatment of inflammation, and there were cases of tendon rupture.
It should not be a serious exercise to practice during treatment with ciprofloxacin.
You can not exceed the maximum daily dosage, as the manifestation of an increased risk of crystalluria. To maintain normal urine output, it is important to take in enough fluids treatment.
In the treatment of the drug can not tolerate the strong UV irradiation.
People with deficiency of glucose-6-phosphate dehydrogenase, the appointment tsiprinol hemolytic anemia can occur.
When antibiotic treatment is necessary to carefully drive traffic and perform other operations associated with increased attention.
Synonyms
Tseprova . Tsiprobay . Kvintor . Tsiploks . Tsiprobid . Tsiprolet . TSifran . Tatsip .
Analogs
Floratsid
Glewe
Avelox
Fleksid
Levolet P
Norbaktin
Ofloksin
TSifran
Tavanic
Nolitsin
Ofloxacin
Analogs having similar effects, are drugs Tsiprovin . Tsiprrosan . Tsiprolon . Tsipropan . Tsiprokvin . Tariferid . Sifloks . Pertti . Renor . Oflomak . Norilet . Oflotsid . Negafloks . Norfatsin and others. All of these analogs may be appointed only after the approval of a physician. About what it is advisable to choose a drug and an antibiotic or not, be sure to ask the treating specialist.
With antibiotics
Allowed tsiprinol combination with ceftazidime and azlocillin the treatment of diseases provoked by Pseudomonas spp. in the treatment of streptococcal infections is permitted combination with mezlocillin, azlocillin, other beta-lactam antibiotics. In the treatment of staphylococcal infections means combined with vancomycin and izoksazolpenitsillinami. In therapy anaerobic infections may be a combination with metronidazole and clindamycin.
With alcohol
It is forbidden to take alcohol during treatment tsiprinol.
Babies
The drug can be administered for the treatment of children and adolescents under 18 years of age only when needed therapy and prevention of anthrax, as well as in the treatment of complications provoked by Pseudomonas aeruginosa, children suffering from cystic fibrosis lungs.
During pregnancy and lactation
You can not assign tsiprinol for treating pregnant women and nursing mothers. Breastfeeding should immediately stop.
Reviews tsiprinol
Testimonials show that using tsiprinol they were able to overcome the infection, which provoked the disease. However, there are a lot of reviews about the manifestation of side effects during therapy. In particular, it refers to the overgrowth, fungal infections, worsening of laboratory blood parameters. It is noted that the antibiotic should be taken during that period is, who was appointed doctor.
Price tsiprinol where to buy
Cost tsiprinol tablets 250 mg averaged 70 rubles. 10 pcs. Price tsiprinol 500 mg averaged 120 rubles. 10 pcs. Price tsiprinol solution for infusion - from 90 to 100 rubles. per 100 ml.
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