Description overdue on 11/28/2014
- Latin name: Klacid SR
- ATC code: J01FA09
- Active substance: Clarithromycin (Clarithromycin)
- Manufacturer: Abbott Laboratories (UK)
- Composition
- Product form
- Pharmacological action
- Pharmacokinetics and pharmacodynamics
- Indications
- Contraindications
- Side effects
- Instructions for use Klatsid CP (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In tablets Klatsid CP contains the active substance clarithromycin and additional components: anhydrous citric acid, lactose, sodium calcium alginate, sodium alginate, povidone K30, talc, magnesium stearate, stearic acid.
Product form
Klatsid SR 500 mg is available as tablets yellow oval which covers the film coating. Tablets prolonged exposure contained in blister packs 5, 7, 10 or 14 pieces in a box may be placed in one or two blisters.
Pharmacological action
Active substance clarithromycin - A semisynthetic antibiotic Belonging to the group of macrolides. It provides an antibacterial effect, to engage with the 50S ribosomal subunit. Thus, there is suppression of bacterial protein which exhibit pronounced sensitivity to the antibiotic.
Due to the homogeneous-based tablets have a prolonged impact. The active agent is released over a long period of time during passage of the drug through the gastrointestinal tract.
Clarithromycin effectively acts on standard laboratory strains of bacteria, and those which have been identified in the course of clinical practice patients. Active substance formulation Klatsid CP active a relatively large number of gram positive and gram negative, aerobic and anaerobic microorganisms.
The substance demonstrates activity against Mycoplasma pneumoniae, Legionella pneumophila, but Pseudomonas spp, Enterobacteriaceae is not affected.
The main metabolite of clarithromycin - a 14-OH clarithromycin being microbiologically active metabolite. With respect to certain microorganisms it has more pronounced activity than the active substance in the initial state.
Pharmacokinetics and pharmacodynamics
The process of clarithromycin metabolism occurs in the liver. The level of bioavailability is about 50%. About 70% of the substance binds to serum proteins. In the tissues and fluids in the body of clarithromycin and its 14-OH metabolite penetrate quickly. Approximately 40% of clarithromycin is excreted through the kidneys, even 30% - through the intestines.
Indications
Klatsid SR prescribed for the treatment of ailments that were provoked by micro-organisms that demonstrate a high sensitivity to the drug. In particular, the infectious nature of the disease that affects the lower divisions ( pneumonia . bronchitis ) And the upper sections ( sinusitis . pharyngitis ) Airway.
Also, the drug is used for treatment of infectious diseases of the skin and soft tissues.
Contraindications
Do not use an antibiotic for treatment, if a person observed such diseases and conditions:
- high sensitivity the constituents of pills and other drugs from the group of macrolides;
- renal failure, severe;
- organism lactose intolerance, glucose-galactose malabsorption, lactose deficiency;
- porphyria ;
- age 18 years.
Not allowed concomitant use of antibiotic Klatsid CP and the following drugs: P imozid . Ac temizol . T erfenadin . Cisapride . Dihydroergotamine . E rgotamin As well as oral forms of preparations M idazolam . A lprazolam . T riazolam .
Tool used with caution in the disruption of the functioning of the kidneys, liver, and myasthenia gravis. We need to be careful while taking those medications metabolized in the liver.
Side effects
The likelihood of developing these side effects in the treatment of these antibiotics:
- Cardiovascular system : In rare cases - ventricular tachycardia , Ventricular fibrillation, QT prolongation on the ECG.
- Digestive System : Dyspepsia, nausea, abdominal pain, diarrhea , Stomatitis, acute pancreatitis , Glossitis, oral candidiasis, pseudomembranous enterocolitis; may experience liver dysfunction, and increased liver enzymes.
- Nervous system : dizziness and headache . insomnia , A feeling of anxiety, tinnitus, convulsions, hallucinations . depression , Psychotic disorders, disorientation.
- Urinary System : Interstitial nephritis.
- Musculoskeletal System : Myalgia.
- Senses : Change in taste or smell, hearing.
- Allergy : hives . anaphylactic reactions . itch and flushing of the skin, rash .
- Laboratory findings : Increase in blood creatinine, thrombocytopenia, hypoglycemia.
Instructions for use Klatsid CP (method and dosage)
Instructions for use Klatsid CP involves taking pills orally entirely. It is advisable to take them with food. For most diseases adult patients received 1 tablet of 500 mg once a day. If severe course of infection, Doha can be doubled (two tablets once a day).
For most diseases treatment period is from 5 to 14 days.
Overdose
When high doses of pills Klatsid CP possible manifestation of disturbances in the functioning of the digestive system. Also described cases of mental status changes, hypokalemia and hypoxemia.
For the treatment to be applied symptomatically. It should wash out the stomach, support of vital functions. Hemodialysis does not significantly affect the content of clarithromycin in serum.
Cooperation
Due to the high probability of serious adverse events is contraindicated while taking clarithromycin with these drugs: Pimozide . Cisapride . Astemizole . Terfenadine . Dihydroergotamine . Ergotamine .
On the level of concentration of clarithromycin in the body of the patient affect a number of drugs, while the treatment that may be required to change medication doses Klatsid CP or replacement of the drug other medicines. This medication Rifabutin . Nevirapine . Efavirenz . Rifapentine . Rifampicin . Fluconazole . Ritonavir.
In simultaneous treatment with clarithromycin and drugs Quinidine or Dizopiramid torsades de pointes may occur.
Carefully Klatsid CP appointed by the people who receive the drug, primarily metabolized isoenzymes CYP3A. In this case it is possible increased side-effects.
Clarithromycin increases the concentration of HMG-CoA reductase ( Simvastatin . Lovastatin ).
At reception Clarithromycin and oral anticoagulants may be enhanced effect of the latter.
In simultaneous treatment Clarithromycin . Tadalafil . Vardenafil or Sildenafil It may require dose reduction of these drugs. Also, you may need to decrease doses of tolterodine.
Simultaneous treatment may lead to increased concentrations of carbamazepine or theophylline in blood.
Do not practice the simultaneous oral Midazolam and clarithromycin.
There may be increased exposure colchicine Especially in the elderly and in patients suffering from renal failure. These people increases the likelihood of poisoning with colchicine. It may also amplify the action Digoxin while taking this antibiotic. It is important to closely control the level of digoxin in the blood.
There bidirectional effect of clarithromycin, and drugs Itraconazole . Atazanavir . Saquinavir . In some cases it may require adjustment of doses of drugs.
Simultaneous treatment Verapamil and clarithromycin may provoke the manifestation of arterial hypotension, bradyarrhythmias.
Terms of sale
Pharmacies Klatsid CP sold by prescription.
Storage conditions
The antibiotic should be protected from the children, kept at a temperature no higher than 30 ° C.
Shelf life
Shelf-life of the antibiotic - 5 years.
Cautions
Staphylococci strains that are resistant to methicillin and oxacillin also exhibit resistance to clarithromycin.
Prolonged antibiotic treatment there may be the appearance of refractory colonies of fungi and bacteria.
During treatment with antibiotics, the patient may manifest pseudomembranous colitis, both mild and severe. Cases of pseudomembranous colitis symptoms two months after taking antibiotics.
Analogs Klatsid CP
Klatsid
Rulid
Klabaks
Fromilid
Azitroks
Hemomitsin
Vilprafen
Rovamycinum
Roxithromycin
Clarithromycin
Azithromycin
Midecamycin
Sumamed
Analogs Klatsid SR 500 mg - are preparations with the same active substance. These are drugs Klatsid . Clarithromycin . Klareksid . Klabaks . Klaritsit . Klaritrosin . Klaromin and etc.
With alcohol
You can not combine Klatsid CP and alcohol, as this may lead to the appearance of significant side effects.
Babies
Klatsid CP is not applicable for the treatment of children and adolescents.
During pregnancy and lactation
There is sufficient information about the treatment of clarithromycin pregnant women and lactating mothers. With pregnancy the antibiotic can be used only if the expected benefit of higher potential risk. If a woman becomes pregnant during treatment with the drug, it is necessary to warn about the possible risk to the fetus. During breast-feeding Treatment pills Klatsid CP is not practiced.
Reviews Klatsid CP
Reviews Klatsid SR 500 mg found in a variety of network. Patients say that antibiotic quickly relieves symptoms of severe infectious diseases, accelerates recovery. But those who did not fit the drug, noted that it provokes the development of unpleasant side effects. To get the expected results, antibiotic treatment should choose the doctor after the study.
Price Klatsid CP where to buy
Price Klatsid SR 500 mg is an average of 460-510 rubles per pack of 5 pieces.
The cost of packaging of tablets 14 pcs. - About 1000 rubles.
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