Description overdue on 06/09/2014
- Latin name: Zincteral
- ATC code: A12CB01
- Active substance: Zinc Sulfate (Zinc Sulfate)
- Manufacturer: TEVA KUTNO, S.A. (Poland)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Tsinkterala
- Contraindications
- Side effects
- Instructions on Tsinkteral
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet contains: Zinc sulfate heptahydrate (based on Zinc sulphate monohydrate ) - 124 mg, or 45 mg Zinc ions .
Excipients: potato starch povidone, talc, magnesium stearate, lactose monohydrate .
The composition of the shell: macrogol (polyoxyethylene glycol), hypromellose (hydroxypropyl methylcellulose), titanium dioxide, azorubinovy varnish.
Product form
Biconvex film-coated tablets pink-purple, rounded.
25 of these tablets in a blister, a blister in a carton box; or 150 of these tablets in the polymer bank, one such bank in a carton box.
Pharmacological action
The drug has a similar effect Vitamins - Micronutrient deficiencies ( Zinc ), Stimulation of the metabolic processes.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Zinc One of the most important trace elements present in the composition of many protein complexes regulating central metabolic processes, namely, protein synthesis and carbohydrate metabolism. Zinc is essential for the proper functioning of more than 200 metalloenzymes (e.g., carboxypeptidase A, alcohol dehydrogenase, carbonic anhydrase, alkaline phosphatase, RNA polymerase, and others.) And to maintain the correct structure of proteins, nucleic acids and cell membranes.
Zinc also promotes the development and growth of cells, proper operation immune system and the immune response, providing twilight vision, sense of taste and odor. It has impact on the preservation of an acceptable level vitamin A serum, extends the insulin and easier to build. In inflammatory diseases of the skin produces preventive and therapeutic effects.
Zinc deficiency causes difficulty concentrating and remembering, appetite disorders and distorted flavor reduction humoral and cellular immunity , Slow healing of wounds, night blindness, hypercholesterolemia , Pathology of carbohydrate metabolism, hypertension , Brain and mental health disorders, prostatic hypertrophy , Pathology of pregnancy, hypogonadism and growth retardation in children, and to a large extent - skin disorders (some species alopecia . acne ). In excessive doses of zinc inhibits absorption of copper. Zinc deficiency increases the absorption of harmful Cadmium .
Pharmacokinetics
Regardless of the concentration of zinc in food, in the small and duodenum adsorbed 25-30% zinc ingested. The maximum zinc content in the blood is achieved within 2 hours after ingestion of the drug. Zinc accumulates in the body mainly in erythrocytes and leukocytes As well as bone, muscle, kidney, liver, skin, Prostate and pancreas, retina . 60% element interacts with albumin 35-40% - with alpha-macroglobulin 1% - with some amino acids ( histidine, cysteine ). Write mainly through the intestine (90%), the rest - with the sweat and urine.
Indications Tsinkterala
- Combined therapy of diseases, leading to a lack of development Zinc .
- Enteropathic acrodermatitis .
- Alopecia hair loss, baldness malignant.
- Purulent acne and pustular .
- When long-term reception corticosteroids At the time of cancellation.
- As an added treat slow-healing wounds.
Contraindications
Hypersensitivity to any component of the formulation.
Cautions: in long-term use of zinc supplements should take into account the risk of copper deficiency; It is forbidden to drink alcohol during treatment with the drug.
Side effects
May experience:
- nausea, heartburn . diarrhea ;
- leukopenia Accompanied by flu-like syndrome ;
- sideroblasticheskaya anemia and general weakness, decline of copper in the blood;
- rarely can occur headache and metallic taste.
Instructions on Tsinkteral
Instructions for use Tsinkterala shows how to take the drug: orally, without chewing during or after a meal.
- At alopecia baldness, enteropathic acrodermatitis : Children from 4 years and adults - 1 tablet three times a day. After the onset of clinical improvement, the dosage was reduced to 1 tablet twice a day, then to 1 tablet per day until symptoms disappear.
- At malignant alopecia : Adults appoint 1-2 tablets three times a day; children from 4 years of age - 1 tablet three times a day.
- From Acne ( purulent and pustular acne ): Adults - 1-2 tablets once a day for children from 4 years -1 tablet a day.
- At deficiency Zinc : Adults -1 tablet three times a day, after the disappearance of symptoms can drink 1 tablet per day; Children from 4 years - 1 tablet per day.
Overdose
An overdose may manifest as a burning sensation in the mouth and throat, watery or bloody diarrhea, belching . dizziness . jaundice . pulmonary edema (shortness of breath, pain in the sternum) hematuria . vomiting . convulsions . collapse . anuria, hemolysis .
In the case of the above symptoms should drink water or milk and then enter intravenously or intramuscularly kaltsiydinatrievuyu etilendiamintetraminuksusnoy acid salt at a dose of 55-75 mg / kg body weight per day (divided into 3-6 administrations) of not more than five days. It is forbidden to induce vomiting or perform gastric lavage.
Cooperation
Tetracycline and copper preparations. The drug reduces the absorption of tetracyclines and slows absorption Copper (when high dosages of zinc), so Tsinkteral should be used within 2 hours after ingestion tetracyclines and preparations Copper .
Thiazide diuretics accelerate the removal of zinc by the kidneys.
A diet containing lots fibrin (bran) Phosphates (dairy products), whole grain products, reduces the adsorption of zinc, so Tsinkteral must be used within 2 hours after a meal rich in these products.
Folic acid also significantly reduces the absorption of zinc.
High doses gland ingestion inhibit zinc absorption (exposure between doses of these medications must be at least two hours)
Penicillamine and others chelating agents reduce the absorption of zinc (exposure between doses of these medications must be at least two hours).
When used with Tsinkteralom vitamin supplements that contain zinc, must be aware of the possibility of the symptoms of overdose.
Quinolone . Tsinkteralom reduces adsorption hinolonsoderzhaschih antimicrobials and fluoroquinolones .
Terms of sale
In Ukraine, the drug is available only by prescription in Russia Tsinkteral available without prescription.
Storage conditions
The drug should be stored at a temperature of 15-20 ° C out of reach of children, dry place.
Do not use after the expiration date.
Shelf life
Shelf life - 3 years.
Cautions
Tsinkteral composition contains lactose So it is contraindicated in patients with a deficit lactose , Intolerance galactose or violation of adsorption Glucose and galactose .
Analogs Tsinkterala
The most famous analogue Tsinkterala called Zinc . The main indication for its use is the lack of zinc in the body.
Babies
Permitted welcome children from 4 years old.
During pregnancy and lactation
Zinc is able to penetrate through placenta . During pregnancy, the drug is used only in cases where the benefit to the mother outweighs the potential risk to the fetus.
Zinc is excreted in breast milk. Therefore, you should refrain from taking the drug during lactation.
Reviews Tsinkterale
Tablets Tsinkteral have a big enough list of indications, so you can hear quite a wide range of comments on its use. When used as a means for hair reviews of Tsinkterale good enough when used as a remedy for acne reviews of Tsinkterale even better.
The drug is also used in bodybuilding and men to improve development Testosterone and stimulation spermatogenesis However, these effects have not been proved.
Doctors about Tsinkterale often show quite a large number of side effects occur, especially on the part of the digestive tract.
Price Tsinkterala
In Russia to buy 25 tablets of the drug will cost you 200-260 rubles, Ukraine Tsinkterala price at the same dosage can be up to 50 hryvnia.
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