Platifillin tartrate

Description overdue on 19.03.2012

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M-holinoblokator . The drug breaks during the process of transmission of nerve impulses to postganglionic cholinergic nerves in the effector tissues and organs. The low degree Platifilllina tartrate inhibits N-cholinergic receptors. Anticholinergic effect is more pronounced at higher tone the parasympathetic nervous system . The drug causes dilation of small blood vessels of the skin, has antispasmodic, myotropic action . High concentrations of the drug to block sympathetic ganglia, oppress vasomotor center That leads to the expansion of the lumen of blood vessels and lower blood pressure (particularly when administered intravenously). The drug reduces the sphincter tone, reduces the secretion of bronchial glands, increases the volume of breath, relaxes the smooth muscles. The drug relaxes circular muscles of the iris, the pupil expands on parenteral administration and instillation of the drug in the conjunctival sac, leading to cycloplegia . The drug causes an increase in intraocular pressure. Platifillin tartrate penetrates blood-brain barrier . The drug is available in tablet form, as a solution.

Indications:

Platifillin tartrate prescribed for pilorospazme , Renal colic, ulcerative lesions of the digestive system, asthma , Renal colic, algodismenoree, bronhoree, angiotrofonevroze , Spasm of cerebral arteries, angina . hypertension , Eye trauma, acute inflammatory diseases of the eye ( keratitis , Iritis, iridocyclitis ), For diagnostic purposes (determination of the true refraction, fundus).

Contraindications:

Platifillin tartrate is not indicated in case of hypersensitivity. During atrial fibrillation, hyperthyroidism, mitral stenosis , Coronary artery disease, acute hemorrhage, hypertension, tachycardia, hyperthermia, reflux esophagitis , Pyloric stenosis, achalasia, intestinal atony, paralytic ileus, angle-closure glaucoma, nonspecific ulcerative colitis . myasthenia , Preeclampsia, dry mouth, Down syndrome liver failure, chronic lung disease, kidney failure, autonomic neuropathy , Prostatic hyperplasia administered with caution.

Side effect:

Platifillin tartrate causes mydriasis , Lowering blood pressure, thirst , Dry mouth, tachycardia , Accommodation paralysis, dizziness, intestinal,   photophobia , Headaches, acute psychosis, urinary retention,   pulmonary atelectasis , Seizures.

Overdose:

Acute urinary retention in patients with BPH, paralytic ileus, paralysis of accommodation, strongly pronounced dryness of the nose and mouth, difficulty in speech, difficulty swallowing, central nervous system depression, agitation, hyperthermia, seizures, tremors, increased intraocular pressure, inhibition of the vasomotor and respiratory centers. Timely gastric lavage, and administration of anticholinesterase drugs holinostimulyatorov   parenterally. When excited by intravenous sodium thiopental or hloralgidrot rectally. When hyperthermia - antipyretics, wet wiping. If mydriasis - pilocarpine , Physostigmine, phosphacol as eyedrops. With the development of glaucoma immediately instilled a solution of pilocarpine vkontsentratsii 1% to 2 drops every hour in each conjunctival sac or subcutaneously three times a day solution neostigmine   0, 05% - 1 ml.

Mode of application:

Platifillina tartrate administered topically, rectally, orally, parenterally in the form of eye drops. Subcutaneous drug is administered in a fit of peripheral, cerebral vasospasm , Bronchial asthma, spastic pain relief for 1-2 times a day for 1-2 milliliters of 0, 2%. In order to reduce blood pressure and vascular expansion drug is administered intravenously. Inside platifillin tartrate administered 2-3 times a day at a dose of 10-15 drops of 0, 5% solution, or by taking 3-5 mg. Suppositories: twice a day for 0, 01g. In microclyster: 2-3 times a day to 20 drops of 0, 5-1%. The duration of treatment is 10-20 days. Ophthalmic Practice: for diagnostic purposes -1%; for therapeutic purposes 2%. Children appoint 0, 2-3 mg orally, depending on the age group.

Special instructions:

Platifillin tartrate may affect the performance of potentially hazardous work.

Drug Interactions:

Platifillin tartrate increases hypnotic and sedative effects of magnesium sulfate, etaminal sodium pentobarbital. The risk of side effects is significantly increased with concomitant administration of amantadine, Mr. holinoblokatorov, MAO inhibitors, phenothiazines, haloperidol , Antihistamines and tricyclic antidepressants . Upon contact with anticholinesterase drugs recorded antagonistic action. When pain, smooth muscle spasm caused by tranquilizers, anxiolytics, sedatives and analgesics increase the effect of the drug. When vascular spasm similar effect is seen with sedatives and antihypertensives .