Konvuleks

Description overdue on 10/14/2014

• Latin name: Convulex
• ATC code: N03AG01
• Active substance: Valproic acid (Valproic acid)
• Manufacturer: GEROT PHARMAZEUTIKA (Austria)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Konvuleks (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

5 ml ampoule containing 500 mg of sodium valproate   (corresponding to 433 mg of 9 valproic acid ).

1 ml of syrup contains 50 mg of active substance. Syrup   It intended for treatment in pediatrics, so it is kind of fruity odor. Additional components: sodium cyclamate, methyl parahydroxybenzoate, peach or raspberry flavoring, saccharin sodium, liquid maltitol.

Capsule   It contains 150, 300 or 500 mg of active substance. Additional components: hydrochloric acid, hydrogenated starch, sorbitol, Karion.

Product form

The drug is available in syrup form (form for children), capsules, drops, and the solution.

The syrup and drops produced in glass vials of a volume of 100 ml. The pack is made of cardboard 1 bottle and a special device for dispensing.

The blister pack contains 10, 20 capsules. The pack of cardboard 5, 10 blisters.

The solution was discharged into 5 ml vials, packed into plastic packaging with cells. The stack of cardboard 5 vials.

Pharmacological action

Antiepileptics Containing valproate Na. The anticonvulsant effect provided two mechanisms of action on the nervous system. Direct mechanism is based on increasing the concentration of valproate in the nervous system; indirect - by modification neurotransmitters And effects on membrane and accumulation of metabolites of the active substance.

Pharmacodynamics and pharmacokinetics

After receiving valproate logged raising gamma-aminobutyric acid . The treatment reduced the period of the interim phase of sleep, increased REM sleep time. The active ingredient is able to penetrate into breast milk, pass through both blood-placenta barrier And blood brain. The highest concentration observed in the extracellular fluid and plasma. In the blood and cerebrospinal fluid accumulates the same amount of valproate.

Binding to plasma proteins is dependent on the dose of medicament (80-95%). Metabolism   the active substance is carried out in the hepatic system. With hemodialysis   the body is derived from only the free fraction. In the pathology of the liver slows down time Withdrawal because of low metabolism.

Indications

The drug is prescribed for all types generalized seizures :

• clonic;
• tonic;
• tonic-clonic.

The drug is used in the form of focal epilepsy   (with and without secondary generalization). With bipolar disorder   and manic syndrome   Valproic acid is also used.

In pediatric practice for the prevention of recurrent febrile seizures appoint syrup Konvuleks (the ineffectiveness of therapy with benzodiazepines).

The solution is used for short-term treatment of epilepsy in individuals who for some reason can not take pills Konvuleks.

Contraindications

• porphyria ;
• severe hepatic pathology system pancreas ;
• Individual hypersensitivity ;
• severe thrombocytopenia (drop in the number Platelet );
• bleeding diathesis .

Precautions valproic acid prescribed for:

• suppression bone marrow hematopoiesis   (anemia, leukopenia);
• pathology of renal system;
• pancreatic diseases phase compensation;
• in severe types of seizures (in Pediatrics);
• Therapy other antiepileptic drugs;
• gipoproteinemii ;
• brain lesions (organic forms);
• congenital enzimopatii .

Side effects Konvuleksa (adverse reactions)

Adverse reactions are recorded in combined therapy and valproic acid at a concentration of 100 mg / l.

The digestive tract:

• anorexia   (or conversely, increased appetite);
• vomiting;
• hepatitis;
• gastralgia;
• constipation ;
• nausea;
• pancreatitis .

Nervous system:

• ataxia ;
• dizziness ;
• coma ;
• impairment of consciousness;
• migraine headache ;
• drowsiness;
• encephalopathy ;
• dysarthria;
• stupor.

Rarely patients changing mood, style of behavior and mental state:

• hallucinations ;
• fatigue;
• depressed mood ;
• excitement;
• psychosis;
• hyperactive state;
• irritability.

Endocrine system:

• an increase in the breast;
• secondary form amenorrhea ;
• dysmenorrhea ;
• galactorrhea.

Side effects from the senses:

• nystagmus;
• diplopia;
• "Flies."

Less changes are recorded by the system hemostasis , Metabolism, allergic responses . alopecia   (reversible reaction), peripheral swelling .

Instructions on Konvuleks (method and dosage)

The syrup is taken per os during the meal (which is allowed after meals). The kit includes a special metering device, which is produced with the help of dosing. The daily amount of valproic acid is recommended to be divided into 3 stages. Selection of dose is carried out taking into account the age and weight of the child and related diseases. In the treatment of other drugs aimed at arresting convulsions Konvuleksa dosing is carried out for 15 days. In assessing the results of treatment, every 2-3 days the correction of dose monotherapy.

The capsules are intended for oral administration, during a meal (when allowed). Inadmissible opening capsules and grinding. The daily dose can be divided into 2 admission. Dosing is carried out individually, titration is carried out for a month at the complex therapy; monotherapy - 7 days. The calculation is performed daily dose according to the scheme of 10-15 mg / kg. Titration is carried out taking into account the plasma concentration of the active ingredient in the blood, portability, efficiency control epipristupami.

Application Instruction Konvuleksa in solution: the medicament is administered intravenously together with a special solvent or as a bolus infusion. The solvent may serve Ringer's solution. The daily dose is calculated by the scheme - 20-30 mg / kg.

Drops administered 2-3 times a day with meals. The initial daily dose - 10/15 mg / kg. Then every 4 days to increase the dose of 200 mg.

Overdose

Symptomatology manifested in a dose dependent manner. In mild cases observed drowsiness . nausea . dizziness . sedation . In severe intoxication respiratory depression develops hyporeflexia, metabolilichesky acidosis , Cramps, giptonus. Rarely develops swelling of the brain   and increased intracranial pressure . Assign chelators , Carried posindromnuyu therapy.

Cooperation

Not recommended to prescribe drugs that induce or reduce seizures seizure threshold . Not to prescribe antipsychotics, fenotiazinaminov. Carbapenems, Aztreonam, and St. John's wort reduces the effectiveness of the drug, increasing the risk of seizures. Phenobarbital and Carbamazepine reduces the level of valproic acid. Konvuleks slows down felbamate. It should tell your doctor about all medications before admission selection dose of valproic acid.

Terms of sale

Strictly prescription.

Storage conditions

Solar radiation destroys the structure of the solution and syrup. Temperature range: 15-25 degrees.

Shelf life

Capsules, solutions and syrup can store five years. Ready solution loses its effectiveness through the day.

Analogs

Match code ATC 4th level:

• Depakine Chronosphere
• Depakine
• Depakine enteric 300
• Depakine Chrono

• Depakine;
• Valparin;
• Keppra;
• Enkorat;
• Konvulsofin.

Babies

Long-acting tablet formulations are contraindicated for children under 3 years. In pediatric practice, a syrup.

During pregnancy (and lactation)

Anticonvulsant therapy with valproic acid assumes the maximum protection pregnancy . Experimental animal studies have revealed marked teratogenic influence   active substance. In 2% of cases detected defects of the nervous system in children who were born to women who took Konvuleks I trimester. Therefore patients expedient appointment of folic acid. With a high probability of seizures a dose of valproic acid is prescribed minimum, and cancel other anticonvulsant medications. Required control indicator of valproic acid in the blood.

Reviews Konvulekse (opinion of patients and physicians)

The drug is actively used in neurological practice for preventing epipripadkov. Portals contain a variety of patient testimonials. Most of them describe all the negative symptoms that can accompany the course of anticonvulsant therapy. We describe the situation where, unable to withstand adverse reactions, patients self-medication canceled, after which the seizures came back again, altering the usual style and way of life of the patients.

Pediatric neurologists prescribe the most accessible form of the drug - Konvuleks syrup for children. Reviews parents confirm the high efficacy of the drug in the treatment of epilepsy, because the number and severity of attacks are significantly reduced, despite the negative effect of valproic acid on the mental abilities of children.

Price Konvuleksa where to buy

Cost antiepileptic depends on the dosage form, region sales and pharmacy chain. Price Konvuleksa in tablet form - 500 rubles (500 mg, 50 pieces), as a solution - 1400 rubles.

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