Description overdue on 04/07/2014
- Latin name: Nolicin
- ATC code: J01MA06
- Active substance: Norfloxacin (Norfloxacin)
- Manufacturer: KRKA, Slovenia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications nolitsin (spectrum use)
- Contraindications
- Side effects
- Instructions for use nolitsin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 tablet contains 400 mg nolitsin norfloxacin . Supporting components : magnesium stearate Microcrystalline cellulose povidone Purified water, anhydrous colloidal silica .
The composition of the shell part propylene glycol Yellow Disperse dyes E110 . titanium dioxide . talc and gipromezola .
Product form
Medicine nolitsin 400 mg is available in tablet form in blister packs of 10, 20 pieces. Photo package can be seen at the beginning of this article.
Pharmacological action
Many wonder: is nolitsin antibiotic or not? The active substance has antimicrobial exposure against staphylococci, klebsiel, enterobacteria, Neisser, Escherichia coli, chlamydia, legionella, salmonella, shigella, and other infectious agents. The mechanism of drug action based on the interaction of norfloxacin DNA gyrase (enzyme microorganism), resulting in destabilization of the DNA chain, and subsequent death of the microorganism. From this we can conclude that it is an antibiotic nolitsin as having a detrimental effect on bacteria.
The antimicrobial effect may last up to 12 hours. Antibiotic nolitsin may be appointed in diseases caused by mycobacteria, enterococci. Wikipedia has a full list of micro-organisms sensitive to the antibiotic.
Pharmacodynamics and pharmacokinetics
The active substance is absorbed quickly enough to Digestive System , Peak blood concentrations recorded after 1-2 hours after receiving medicament. The bioavailability of the drug reaches 30-40%. About 15% of the active ingredient bound to plasma proteins.
The drug is discharged through renal system unchanged, and only a small part is eliminated through the digestive tract. In patients with severe renal pathology of pharmacokinetic parameters changed.
Indications nolitsin (spectrum use)
Tablets nolitsin, from what are they? The drug is indicated for the treatment of diseases of the genitourinary system infectious-inflammatory:
- chronic bacterial prostatitis flowing genesis;
- endometritis;
- cervicitis;
- cystitis;
- pyelonephritis;
- urethritis;
- uncomplicated gonorrhea.
From what can still be assigned nolitsin: bacterial gastroenteritis, shigellosis . salmonellosis . Additional indications for use of the tablets: the prevention of traveler's diarrhea and prevention of septic complications in patients with neutropenia .
Contraindications (absolute and relative)
Abstract to the drug contains the following absolute contraindications:
- intolerance of fluoroquinolones;
- child bearing;
- congenital lack of the enzyme glucose-6-phosphate dehydrogenase.
The drug is not applicable in pediatrics.
Relative contraindications:
- Allergic responses to aspirin;
- epileptic syndrome;
- disorders of cerebral blood supply;
- atherosclerotic changes in cerebral vessels;
Side effects nolitsin (negative effect)
With the genitourinary system:
- hypercreatininemia;
- glomerulonephritis;
- polyuria;
- Urethral bleeding ;
- crystalluria;
- dysuria;
- albuminuria.
From the digestive tract:
- pseudomembranous enterocolitis;
- epigastric pain;
- eating disorders;
- diarrheal syndrome;
- vomiting;
- nausea;
- bitter taste in the mouth;
- increase in ALT, AST.
Perhaps the development of hallucinations, headaches, arrhythmia, tachycardia , Vasculitis, pruritus, syncope, insomnia, edema, urticaria, exudative erythema with a malignant course. Rarely recorded candidiasis, reduced hematocrit, changes of blood parameters, arthralgia , Chemosis, fear of light.
Instructions for use nolitsin (method and dosage)
How to use the drug nolitsin? Instructions for applying are encouraged to take the medication inside.
With infection of the genitourinary system: twice daily at 400 mg, the course of 7-10 days.
Treatment uncomplicated cystitis It held for 3-7 days.
Chronic recurrent urinary tract infections treated for 12 weeks.
How to take when nolitsin acute gastroenteritis of bacterial origin : Twice a day at 400 mg per day for 5 days. When cervicitis, proctitis, and pharyngitis urethritis once administered 400 mg of norfloxacin.
Overdose
Manifested intense vomiting, nausea, dizziness, drowsiness, " cold " later. Therapy involves performing hydration treatment with forced diuresis, gastric lavage . The specific antidote is not developed.
Cooperation
The medicament reduces efficiency nitrofurans Increases the concentration cyclosporine (mutual action), and anticoagulants . Norfloxacin reduces the overall clearance of theophylline 1/4.
When concurrent therapy with drugs that reduce the epileptic threshold may be amplified epileptiform seizures . Antacids reduce the absorption nolitsin. When receiving antihypertensives recorded a sharp drop in blood pressure. The use of drugs for general anesthesia requires mandatory control heart rate, blood pressure figures, the work of the heart (ECG).
Terms of sale
Sold in pharmacies with the mandatory presentation of medical prescription form with the seal of the doctor and the institution.
Storage conditions
In a dark place, away from children. Temperature range - up to 25 degrees Celsius.
Shelf life
5 years.
Cautions
Before the appointment of antibiotics is necessary to determine the sensitivity of the flora to norfloxacin. What is it held? Germs can be sensitive to the drug, and the expected therapeutic effect is reached at the right time.
With pyelonephritis Nolitsin recommended to be administered in combination with drugs of plant origin (eg Kanefron). In the treatment of pyelonephritis norfloxacin reviews mostly positive. Monural also used for the treatment of diseases of the genitourinary system. The fact that it is better to appoint, can only solve the attending physician.
Analogs nolitsin in Russia
Floratsid
Glewe
Avelox
Fleksid
Levolet P
Norbaktin
Tsiprinol
Ofloksin
TSifran
Tavanic
Ofloxacin
Lokson-400 Sofazin, Norfatsin, Norilet, Norbaktin , Renor.
Babies
In pediatrics is not applicable. Age limit - 18 years.
With alcohol (adverse reactions)
Alcohol and nolitsin not combined. Ethanol-containing drinks have a negative effect on the liver function and overall condition of the patient.
When pregnancy (early and late dates)
Nolitsin may be appointed only for health reasons in the II and III trimester. In the early stages of the medication is absolutely contraindicated.
Reviews nolitsin (Opinion of doctors and patients)
Reviews on nolitsin cystitis very positive. The drug quickly enough relieves all the unpleasant symptoms (frequent urination, pain). Nolitsin - a cheap and effective antibiotic for cystitis. Only a doctor can prescribe the drug and explain how to take cystitis. Reviews physicians indicate that nolitsin is one of the drugs of choice in the treatment of urinary tract diseases.
Price nolitsin in Ukraine, where to buy
The price of the tablet depends on the packaging: 10 pcs - 90grn, 20 pieces - 195grn. Buy nolitsin in Russia can be priced at respectively 130 and 250 rubles. About how much medicine is in your area, please call the pharmacy network.
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