Description overdue on 09/26/2014
- Latin name: Rozamet
- ATC code: D06BX01
- Active substance: Metronidazole (Metronidazole)
- Manufacturer: JSC "core" Galenski Laboratories, Croatia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Cream Rozamet, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
Rozamet Ointment contains the active ingredient metronidazole (10 mg), as well as propylene glycol, purified water, methyl parahydroxybenzoate, liquid paraffin, propyl parahydroxybenzoate, glycerol, emulsifying wax.
Product form
The homogeneous 1% cream white odorless. Available in aluminum tube of 25 grams, which is in the carton.
Pharmacological action
The gel has antimicrobial and antiprotozoal local impact.
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug - metronidazole Which has antibacterial and antiprotozoal activity, causing DNA damage microbial cells and stopping the synthesis of nucleic acids. Also it has antioxidant activity, due to which in inflammation decreases oxidative stress.
Substance ineffective against telangiectasia That are marked at pink acne.
The drug is in the local application is practically not absorbed. Data on the metabolism and excretion of the active ingredient after topical application is not available. Metronidazole is metabolized in the liver and excreted by the kidneys.
Indications
It is recommended to prescribe a cream Rozamet in the following cases:
- when poststeroidnyh Rosacea (pink acne);
- bedsores ;
- pink acne Manifested in age hormonal changes;
- trophic ulcers ;
- acne vulgaris ;
- vulvovaginal ;
- pustular skin lesions;
- seborrheic dermatitis ;
- infection papular rash ;
- balanoposthitis ;
- infectious eczema ;
- dermatitis unspecified origin.
Contraindications
Contraindications Rozamet acne patients with hypersensitivity to metronidazole . derivative parabens Imidazole and other similar compounds.
The drug is considered conventionally contraindicated during the first trimester of pregnancy and lactation period.
Side effects
During therapy with Rozamet side effects seen very rarely and in a rather mild form, it is easily tolerated when applied topically.
In most allergic reactions such as hives . rash , Irritation (redness, burning, dryness, stinging, a local increase in the temperature of the skin), pruritus. Cause such a reaction may be other substances that are part of the preparation: methyl parahydroxybenzoate and propyl parahydroxybenzoate. Allergic reaction It may be postponed.
Watery may be caused by application of the gel in the eye.
Rate reactions to metronidazole is quite difficult, because most of the symptoms described above, as inherent Rosacea .
Systemic side effects from the use of drugs is unlikely, since the concentration of the drug in topical use is very low.
Cream Rozamet, instructions for use (method and dosage)
It is used topically.
Instructions on the treatment of Rozamet erythema , Inflammation pustules . papules . acne vulgaris : Skin previously cleaned with warm water and detergent, after the thin layer of ointment is rubbed. The procedure must be repeated up to 2 times a day: in the morning and evening. The course of treatment is 1-2 months. After cleansing the skin prior to application of the gel should be at least 15 minutes, thereby reducing the risk of inflammation. The therapeutic effect is observed on the average three weeks.
With balanoposthitis and vulvovaginal a small amount of cream applied with a finger or a cotton swab while rubbing slug. Areas of application: lesions of the foreskin, the area of the labia minora, glans penis, the area of the vestibule. The ointment is applied 1-2 times per day. The duration of treatment typically is from 8 to 10 days.
Overdose
Cases of overdose when using this drug is not recorded. The excess of the therapeutic dose of metronidazole is unlikely. When applied topically, the substance is absorbed in small quantities, without causing systemic effects.
Cooperation
Interaction Rozamet cream when applied topically with other drugs have been identified, and the recommended caution in parallel using this and other drugs.
Metronidazole increases anticoagulant effect Warfarin and other coumarin anticoagulants. This leads to a lengthening of the period of formation of prothrombin.
Reduced antimicrobial activity phenobarbital interacting with metronidazole because of the rapid metabolism of the latter.
Concomitant use with Rozameta disulfiram enhances drug toxicity, causing neurological symptoms may develop.
Cimetidine inhibition promotes metabolism metronidazole, which may increase its level in the serum.
To avoid the development of disulfiramopodobnyh reactions during therapy Rozametom should refrain from drinking alcohol.
Terms of sale
Buy drug without a prescription is possible.
Storage conditions
The optimum storage temperature Rozamet cream - not above 25 ° C.
Shelf life
Keep the drug can be for 24 months.
Cautions
Designed exclusively for external use. When used to avoid contact with eyes as this may cause irritation of the eyes. During treatment is recommended to avoid direct sunlight on the affected areas of the skin.
No effect on ability to drive and focus.
Analogs
Metrogil
The drugs with similar pharmacological action: Gravagin . Metrid . Metrogil . Metrozol . Metronidazole . Rozeks . Trikasayd . Trichopolum . Flagyl . Efloran .
Is it better or Rozeks Rozamet?
Both drugs have a similar composition. In Rozeksa wider list of indications, it can also be applied for burns, oily seborrhea and weak healing wounds. Rozeks contraindicated in leukopenia, epilepsy and liver failure. It should also be noted that, unlike Rozameta, Rozeks may have adverse effects on the organs of the gastrointestinal tract, nervous system, sense organs, urogenital system, cause allergic reactions and local inflammation.
Babies
Not recommended to appoint Rozamet children under 12 years since efficacy and safety of the drug in this age group have not been studied.
During pregnancy and lactation
When breast-feeding material in much larger doses enters the breast milk of the mother. In the first trimester of pregnancy, the use of the drug is contraindicated during the second and third trimesters should appoint only when absolutely necessary.
Should be suspended lactation at the time of treatment.
Reviews Rozamete
Rating product among buyers is quite high - 4, 5 points. Reviews Rozamete occur more often positive: the ointment is very good for acne, inflammation, not dry the skin. In addition, side effects from application of the ointment the patients is observed. The apparent effect of the ointment is observed within 2-3 weeks. However, not all the ointment works so well: reviews of cream Rozamet meet and negative. Some patients say that after using the gel began to appear new spots, while trying to dry, but not disappeared.
Price Rozameta
In Moscow, the price of cream Rozamet is within 125 - 158 rubles.
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