Preductal

Description overdue on 24.01.2012

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Antihypoxic means . Main, an active substance - trimetazidine . The drug has a hypotensive, anti-hypoxic, vasodilatig, antianginal effects. The mechanism of action is based in the optimization function and metabolism of brain neurons and cardiomyocytes. Due to rationalization of consumption of oxygen activation oxidative decarboxylation , Increase energy potential is achieved cytoprotective action   drug. Rationalization of the consumption of oxygen is carried out as a result of the blockade of fatty acid oxidation, strengthening aerobic glycolysis . Preductal prevents intracellular depletion of phosphocreatine and ATP support myocardial contractility. If acidosis trimetazidine normalizes the concentration of potassium ions, prevents the accumulation of sodium and calcium in cardiomyocytes, normalizes the functioning of ionic membrane channels. Under the influence of the drug decreases the concentration of phosphate and reduced intracellular acidosis myocardial ischemia . Preductal reduces the severity of ischemic damage to the myocardium, reduces the yield of CK cells, increases the electrical potential, prevents activation of neutrophils in the ischemic area, preserves the integrity of cell membranes and prevents the damaging effects of free radicals. In patients with diseases of the upper respiratory tract improves results vestibular trial A positive effect on hearing, reduces the noise in the ears and dizziness. Individuals with angina   the drug after 2 weeks of treatment reduced blood pressure fluctuations, increased exercise tolerance, reduced intake of nitrates, reduced the frequency of attacks. Preductal is available in tablet form.

Indications and contraindications:

In cardiology   Preductal prescribed to prevent attacks angina   (combination therapy, monotherapy), long-term treatment of coronary heart disease. In ophthalmology   the drug used in the chorioretinal pathology   ENT-diseases : Hearing loss, noise in check, dizziness,   ischemic. Preductal is contraindicated in case of intolerance to trimetazidine. Not available in pediatric patients. As a result of experimental studies on animals teratogenic effects have been identified, but data on the effect of the drug on the fetus is not. Data on drug excretion in breast milk is not, so it is advisable to refrain from the use of trimetazidine during breastfeeding.

Side effect:

The drug can cause Preductal weakly dyspepsia, allergic reactions.

Mode of application:

Drug taken twice daily (70 mg daily).

Special instructions:

Preductal not apply in myocardial infarction, an initial course of treatment unstable angina , The drug does not relieves angina. Not recommended for people with severe pathology of the renal system. Preductal does not affect the performance of a complex operation, management mechanisms, driving vehicles. Special storage conditions is not required, it is recommended to take care of children. The pharmacy items released in the presence of a doctor prescription form.